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Lukas E. Dow
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Journal Articles

Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

Zhuxuan Li, Xueqian Zhuang, Chun-Hao Pan, Yan Yan, Rohit Thummalapalli, Jill Hallin, Stefan Torborg, Anupriya Singhal, Jason C. Chang, Eusebio Manchado, Lukas E. Dow, Rona Yaeger, James G. Christensen, Scott W. Lowe, Charles M. Rudin, Simon Joost, Tuomas Tammela
Journal: Cancer Discovery
Cancer Discov (2024) 14 (2): 308–325.
https://doi.org/10.1158/2159-8290.CD-23-0289
Published: 08 February 2024
View article titled, Alveolar Differentiation Drives Resistance to <em>KRAS</em> Inhibition in Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

WNT as a Driver and Dependency in Cancer

Marie J. Parsons, Tuomas Tammela, Lukas E. Dow
Journal: Cancer Discovery
Cancer Discov (2021) 11 (10): 2413–2429.
https://doi.org/10.1158/2159-8290.CD-21-0190
Published: 01 October 2021
View article titled, WNT as a Driver and Dependency in Cancer
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Journal Articles

Revealing ARID1A Function in Gastric Cancer from the Bottom Up

Maria Paz Zafra, Lukas E. Dow
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1327–1329.
https://doi.org/10.1158/2159-8290.CD-21-0271
Published: 01 June 2021
View article titled, Revealing ARID1A Function in Gastric Cancer from the Bottom Up
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Journal Articles

An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants

Maria Paz Zafra, Marie J. Parsons, Jangkyung Kim, Direna Alonso-Curbelo, Sukanya Goswami, Emma M. Schatoff, Teng Han, Alyna Katti, Maria Teresa Calvo Fernandez, John E. Wilkinson, Elena Piskounova, Lukas E. Dow
Journal: Cancer Discovery
Cancer Discov (2020) 10 (11): 1654–1671.
https://doi.org/10.1158/2159-8290.CD-20-0442
Published: 02 November 2020
View article titled, An <em>In Vivo Kras</em> Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants
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Includes: Supplementary data
Journal Articles

Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy

Laura Hinze, Roxane Labrosse, James Degar, Teng Han, Emma M. Schatoff, Sabine Schreek, Salmaan Karim, Connor McGuckin, Joshua R. Sacher, Florence Wagner, Martin Stanulla, Chen Yuan, Ewa Sicinska, Marios Giannakis, Kimmie Ng, Lukas E. Dow, Alejandro Gutierrez
Journal: Cancer Discovery
Cancer Discov (2020) 10 (11): 1690–1705.
https://doi.org/10.1158/2159-8290.CD-19-1472
Published: 02 November 2020
View article titled, Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy
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Includes: Supplementary data
Journal Articles

Lineage Reversion Drives WNT Independence in Intestinal Cancer

Teng Han, Sukanya Goswami, Yang Hu, Fanying Tang, Maria Paz Zafra, Charles Murphy, Zhen Cao, John T. Poirier, Ekta Khurana, Olivier Elemento, Jaclyn F. Hechtman, Karuna Ganesh, Rona Yaeger, Lukas E. Dow
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1590–1609.
https://doi.org/10.1158/2159-8290.CD-19-1536
Published: 01 October 2020
View article titled, Lineage Reversion Drives WNT Independence in Intestinal Cancer
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Includes: Supplementary data
Journal Articles

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis

Josef Leibold, Marcus Ruscetti, Zhen Cao, Yu-Jui Ho, Timour Baslan, Min Zou, Wassim Abida, Judith Feucht, Teng Han, Francisco M. Barriga, Kaloyan M. Tsanov, Leah Zamechek, Amanda Kulick, Corina Amor, Sha Tian, Katarzyna Rybczyk, Nelson R. Salgado, Francisco J. Sánchez-Rivera, Philip A. Watson, Elisa de Stanchina, John E. Wilkinson, Lukas E. Dow, Cory Abate-Shen, Charles L. Sawyers, Scott W. Lowe
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (7): 1038–1057.
https://doi.org/10.1158/2159-8290.CD-19-1242
Published: 01 July 2020
View article titled, Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis
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Includes: Supplementary data
Journal Articles

Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition

Emma M. Schatoff, Sukanya Goswami, Maria Paz Zafra, Miguel Foronda, Michael Shusterman, Benjamin I. Leach, Alyna Katti, Bianca J. Diaz, Lukas E. Dow
Journal: Cancer Discovery
Cancer Discov (2019) 9 (10): 1358–1371.
https://doi.org/10.1158/2159-8290.CD-19-0289
Published: 01 October 2019
View article titled, Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition
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Includes: Supplementary data