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Journal Articles

The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors

Free
Marika Pinnelli, Livio Trusolino
Journal: Cancer Discovery
Cancer Discov (2021) 11 (8): 1874–1876.
https://doi.org/10.1158/2159-8290.CD-21-0609
Published: 01 August 2021
View articletitled, The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors
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Journal Articles

Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes

Available to Purchase
Marco Avolio, Livio Trusolino
Journal: Cancer Discovery
Cancer Discov (2021) 11 (7): 1644–1660.
https://doi.org/10.1158/2159-8290.CD-20-1531
Published: 01 July 2021
View articletitled, Rational Treatment of Metastatic Colorectal Cancer: A Reverse Tale of Men, Mice, and Culture Dishes
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Journal Articles

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Available to Purchase
Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Bob T. Li, Neal Rosen, Federica Di Nicolantonio, Alberto Bardelli, Sandra Misale
Journal: Cancer Discovery
Cancer Discov (2020) 10 (8): 1129–1139.
https://doi.org/10.1158/2159-8290.CD-20-0187
Published: 03 August 2020
View articletitled, EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Oncogenic MET as an Effective Therapeutic Target in Non–Small Cell Lung Cancer Resistant to EGFR Inhibitors: The Rise of the Phoenix

Free
Livio Trusolino
Journal: Cancer Discovery
Cancer Discov (2016) 6 (12): 1306–1308.
https://doi.org/10.1158/2159-8290.CD-16-1181
Published: 04 December 2016
View articletitled, Oncogenic MET as an Effective Therapeutic Target in Non–Small Cell Lung Cancer Resistant to EGFR Inhibitors: The Rise of the Phoenix
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Journal Articles

HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment

Free
Shyam M. Kavuri, Naveen Jain, Francesco Galimi, Francesca Cottino, Simonetta M. Leto, Giorgia Migliardi, Adam C. Searleman, Wei Shen, John Monsey, Livio Trusolino, Samuel A. Jacobs, Andrea Bertotti, Ron Bose
Journal: Cancer Discovery
Cancer Discov (2015) 5 (8): 832–841.
https://doi.org/10.1158/2159-8290.CD-14-1211
Published: 03 August 2015
View articletitled, HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment
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Includes: Supplementary data
Journal Articles

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Free
Manuel Hidalgo, Frederic Amant, Andrew V. Biankin, Eva Budinská, Annette T. Byrne, Carlos Caldas, Robert B. Clarke, Steven de Jong, Jos Jonkers, Gunhild Mari Mælandsmo, Sergio Roman-Roman, Joan Seoane, Livio Trusolino, Alberto Villanueva, for the EurOPDX Consortium
Journal: Cancer Discovery
Cancer Discov (2014) 4 (9): 998–1013.
https://doi.org/10.1158/2159-8290.CD-14-0001
Published: 01 September 2014
View articletitled, Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
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Includes: Supplementary data
Journal Articles

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

Free
Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Giulia Siravegna, Andrea Sartore-Bianchi, Elisa Scala, Andrea Cassingena, Davide Zecchin, Maria Apicella, Giorgia Migliardi, Francesco Galimi, Calogero Lauricella, Carlo Zanon, Timothy Perera, Silvio Veronese, Giorgio Corti, Alessio Amatu, Marcello Gambacorta, Luis A. Diaz, Jr, Mark Sausen, Victor E. Velculescu, Paolo Comoglio, Livio Trusolino, Federica Di Nicolantonio, Silvia Giordano, Salvatore Siena
Journal: Cancer Discovery
Cancer Discov (2013) 3 (6): 658–673.
https://doi.org/10.1158/2159-8290.CD-12-0558
Published: 06 June 2013
View articletitled, Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Compensatory Pathways in Oncogenic Kinase Signaling and Resistance to Targeted Therapies: Six Degrees of Separation

Free
Livio Trusolino, Andrea Bertotti
Journal: Cancer Discovery
Cancer Discov (2012) 2 (10): 876–880.
https://doi.org/10.1158/2159-8290.CD-12-0400
Published: 14 October 2012
View articletitled, Compensatory Pathways in Oncogenic Kinase Signaling and Resistance to Targeted Therapies: Six Degrees of Separation
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Journal Articles

A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Free
Andrea Bertotti, Giorgia Migliardi, Francesco Galimi, Francesco Sassi, Davide Torti, Claudio Isella, Davide Corà, Federica Di Nicolantonio, Michela Buscarino, Consalvo Petti, Dario Ribero, Nadia Russolillo, Andrea Muratore, Paolo Massucco, Alberto Pisacane, Luca Molinaro, Emanuele Valtorta, Andrea Sartore-Bianchi, Mauro Risio, Lorenzo Capussotti, Marcello Gambacorta, Salvatore Siena, Enzo Medico, Anna Sapino, Silvia Marsoni, Paolo M. Comoglio, Alberto Bardelli, Livio Trusolino
Journal: Cancer Discovery
Cancer Discov (2011) 1 (6): 508–523.
https://doi.org/10.1158/2159-8290.CD-11-0109
Published: 16 November 2011
View articletitled, A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
Open the PDF for A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer in another window
Includes: Supplementary data