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Journal Articles

The Hallmarks of a Cancer Discovery

Luis A. Diaz, Lewis C. Cantley

Cancer Discov (2023) 13 (4): 797–798.

https://doi.org/10.1158/2159-8290.CD-23-0171

Published: 03 April 2023

View article titled, The Hallmarks of a Cancer Discovery

Journal Articles

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley

Cancer Discov (2023) 13 (4): 1002–1025.

https://doi.org/10.1158/2159-8290.CD-22-0805

Published: 03 April 2023

View article titled, LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

Includes: Supplementary data

Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher

Cancer Discov (2022) 12 (11): 2475–2481.

https://doi.org/10.1158/2159-8290.CD-22-1105

Published: 02 November 2022

View article titled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Journal Articles

A Decade of Cancer Discovery

Luis A. Diaz, Lewis C. Cantley

Cancer Discov (2021) 11 (4): 795–797.

https://doi.org/10.1158/2159-8290.CD-21-0082

Published: 01 April 2021

View article titled, A Decade of Cancer Discovery

Journal Articles

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Cancer Discov (2020) 10 (9): 1352–1373.

https://doi.org/10.1158/2159-8290.CD-19-1228

Published: 01 September 2020

View article titled, Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Includes: Supplementary data

Journal Articles

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

Hui Liu, Marcia N. Paddock, Haibin Wang, Charles J. Murphy, Renee C. Geck, Adrija J. Navarro, Gerburg M. Wulf, Olivier Elemento, Volker Haucke, Lewis C. Cantley, Alex Toker

Cancer Discov (2020) 10 (8): 1226–1239.

https://doi.org/10.1158/2159-8290.CD-19-1262

Published: 03 August 2020

View article titled, The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

Includes: Supplementary data

Journal Articles

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Hui Liu, Charles J. Murphy, Florian A. Karreth, Kristina B. Emdal, Forest M. White, Olivier Elemento, Alex Toker, Gerburg M. Wulf, Lewis C. Cantley

Cancer Discov (2018) 8 (3): 354–369.

https://doi.org/10.1158/2159-8290.CD-17-0679

Published: 01 March 2018

View article titled, Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Includes: Supplementary data

Journal Articles

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Cancer Discov (2017) 7 (7): 750–765.

https://doi.org/10.1158/2159-8290.CD-16-0778

Published: 05 July 2017

View article titled, Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Includes: Supplementary data

Journal Articles

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

Cancer Discov (2017) 7 (5): 462–477.

https://doi.org/10.1158/2159-8290.CD-16-1154

Published: 30 April 2017

View article titled, Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

Includes: Supplementary data

Journal Articles

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

Deepti Mathur, Elias Stratikopoulos, Sait Ozturk, Nicole Steinbach, Sarah Pegno, Sarah Schoenfeld, Raymund Yong, Vundavalli V. Murty, John M. Asara, Lewis C. Cantley, Ramon Parsons

Cancer Discov (2017) 7 (4): 380–390.

https://doi.org/10.1158/2159-8290.CD-16-0612

Published: 02 April 2017

View article titled, PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

Includes: Supplementary data

Journal Articles

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Anguraj Sadanandam, Stephan Wullschleger, Costas A. Lyssiotis, Carsten Grötzinger, Stefano Barbi, Samantha Bersani, Jan Körner, Ismael Wafy, Andrea Mafficini, Rita T. Lawlor, Michele Simbolo, John M. Asara, Hendrik Bläker, Lewis C. Cantley, Bertram Wiedenmann, Aldo Scarpa, Douglas Hanahan

Cancer Discov (2015) 5 (12): 1296–1313.

https://doi.org/10.1158/2159-8290.CD-15-0068

Published: 03 December 2015

View article titled, A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Includes: Supplementary data

Journal Articles

PtdIns(3,4,5)P₃-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Bing Su, Wenyi Wei

Cancer Discov (2015) 5 (11): 1194–1209.

https://doi.org/10.1158/2159-8290.CD-15-0460

Published: 01 November 2015

View article titled, PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Includes: Supplementary data

Journal Articles

Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition

Cancer Discov (2014) 4 (8): 896–904.

https://doi.org/10.1158/2159-8290.CD-13-0230

Published: 03 August 2014

View article titled, Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition

Includes: Supplementary data

Journal Articles

What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Samuel J. Klempner, Andrea P. Myers, Lewis C. Cantley

Cancer Discov (2013) 3 (12): 1345–1354.

https://doi.org/10.1158/2159-8290.CD-13-0063

Published: 10 December 2013

View article titled, What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Journal Articles

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Cancer Discov (2013) 3 (8): 870–879.

https://doi.org/10.1158/2159-8290.CD-13-0015

Published: 07 August 2013

View article titled, Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Includes: Supplementary data

Journal Articles

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas A. Lyssiotis, Caterina Nardella, Pier Paolo Pandolfi, José Baselga, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf

Cancer Discov (2012) 2 (11): 1048–1063.

https://doi.org/10.1158/2159-8290.CD-11-0336

Published: 11 November 2012

View article titled, Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Includes: Supplementary data

Journal Articles

Cancer Discovery at One Year: The Editors' Interim Analysis

Lewis C. Cantley, PhD, José Baselga, MD, PhD

Cancer Discov (2012) 2 (1): vi.

https://doi.org/10.1158/2159-8290.CD-11-0327

Published: 12 January 2012

View article titled, Cancer Discovery at One Year: The Editors' Interim Analysis

Journal Articles

The APL Paradigm and the “Co-Clinical Trial” Project

Caterina Nardella, Andrea Lunardi, Akash Patnaik, Lewis C. Cantley, Pier Paolo Pandolfi

Cancer Discov (2011) 1 (2): 108–116.

https://doi.org/10.1158/2159-8290.CD-11-0061

Published: 17 July 2011

View article titled, The APL Paradigm and the “Co-Clinical Trial” Project

Journal Articles

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Lydia W.T. Cheung, Bryan T. Hennessy, Jie Li, Shuangxing Yu, Andrea P. Myers, Bojana Djordjevic, Yiling Lu, Katherine Stemke-Hale, Mary D. Dyer, Fan Zhang, Zhenlin Ju, Lewis C. Cantley, Steven E. Scherer, Han Liang, Karen H. Lu, Russell R. Broaddus, Gordon B. Mills

Cancer Discov (2011) 1 (2): 170–185.

https://doi.org/10.1158/2159-8290.CD-11-0039

Published: 17 July 2011

View article titled, High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

Includes: Multimedia, Supplementary data

Journal Articles

The Era of Cancer Discovery

Lewis C. Cantley, PhD, José Baselga, MD, PhD

Cancer Discov (2011) 1 (1): 1.

https://doi.org/10.1158/2159-8274.CD-11-0049

Published: 01 June 2011

View article titled, The Era of Cancer Discovery

NARROW

The Hallmarks of a Cancer Discovery

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

A Decade of Cancer Discovery

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

PtdIns(3,4,5)P₃-Dependent Activation of the mTORC2 Kinase Complex

Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition

What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Cancer Discovery at One Year: The Editors' Interim Analysis

The APL Paradigm and the “Co-Clinical Trial” Project

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

The Era of Cancer Discovery

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