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Journal Articles

The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Cancer Discov (2020) 10 (8): 1174–1193.

https://doi.org/10.1158/2159-8290.CD-19-1390

Published: 03 August 2020

View article titled, The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

Includes: Supplementary data

Journal Articles

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas

Ophélia Maertens, Ryan Kuzmickas, Haley E. Manchester, Chloe E. Emerson, Alessandra G. Gavin, Caroline J. Guild, Terence C. Wong, Thomas De Raedt, Christian Bowman-Colin, Elodie Hatchi, Levi A. Garraway, Keith T. Flaherty, Shailja Pathania, Stephen J. Elledge, Karen Cichowski

Cancer Discov (2019) 9 (4): 526–545.

https://doi.org/10.1158/2159-8290.CD-18-0879

Published: 01 April 2019

View article titled, MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas

Includes: Supplementary data

Journal Articles

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Andrew J. Aguirre, Jonathan A. Nowak, Nicholas D. Camarda, Richard A. Moffitt, Arezou A. Ghazani, Mehlika Hazar-Rethinam, Srivatsan Raghavan, Jaegil Kim, Lauren K. Brais, Dorisanne Ragon, Marisa W. Welch, Emma Reilly, Devin McCabe, Lori Marini, Kristin Anderka, Karla Helvie, Nelly Oliver, Ana Babic, Annacarolina Da Silva, Brandon Nadres, Emily E. Van Seventer, Heather A. Shahzade, Joseph P. St. Pierre, Kelly P. Burke, Thomas Clancy, James M. Cleary, Leona A. Doyle, Kunal Jajoo, Nadine J. McCleary, Jeffrey A. Meyerhardt, Janet E. Murphy, Kimmie Ng, Anuj K. Patel, Kimberly Perez, Michael H. Rosenthal, Douglas A. Rubinson, Marvin Ryou, Geoffrey I. Shapiro, Ewa Sicinska, Stuart G. Silverman, Rebecca J. Nagy, Richard B. Lanman, Deborah Knoerzer, Dean J. Welsch, Matthew B. Yurgelun, Charles S. Fuchs, Levi A. Garraway, Gad Getz, Jason L. Hornick, Bruce E. Johnson, Matthew H. Kulke, Robert J. Mayer, Jeffrey W. Miller, Paul B. Shyn, David A. Tuveson, Nikhil Wagle, Jen Jen Yeh, William C. Hahn, Ryan B. Corcoran, Scott L. Carter, Brian M. Wolpin

Cancer Discov (2018) 8 (9): 1096–1111.

https://doi.org/10.1158/2159-8290.CD-18-0275

Published: 04 September 2018

View article titled, Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Includes: Supplementary data

Journal Articles

Genetic Mechanisms of Immune Evasion in Colorectal Cancer

Catherine S. Grasso, Marios Giannakis, Daniel K. Wells, Tsuyoshi Hamada, Xinmeng Jasmine Mu, Michael Quist, Jonathan A. Nowak, Reiko Nishihara, Zhi Rong Qian, Kentaro Inamura, Teppei Morikawa, Katsuhiko Nosho, Gabriel Abril-Rodriguez, Charles Connolly, Helena Escuin-Ordinas, Milan S. Geybels, William M. Grady, Li Hsu, Siwen Hu-Lieskovan, Jeroen R. Huyghe, Yeon Joo Kim, Paige Krystofinski, Mark D.M. Leiserson, Dennis J. Montoya, Brian B. Nadel, Matteo Pellegrini, Colin C. Pritchard, Cristina Puig-Saus, Elleanor H. Quist, Ben J. Raphael, Stephen J. Salipante, Daniel Sanghoon Shin, Eve Shinbrot, Brian Shirts, Sachet Shukla, Janet L. Stanford, Wei Sun, Jennifer Tsoi, Alexander Upfill-Brown, David A. Wheeler, Catherine J. Wu, Ming Yu, Syed H. Zaidi, Jesse M. Zaretsky, Stacey B. Gabriel, Eric S. Lander, Levi A. Garraway, Thomas J. Hudson, Charles S. Fuchs, Antoni Ribas, Shuji Ogino, Ulrike Peters

Cancer Discov (2018) 8 (6): 730–749.

https://doi.org/10.1158/2159-8290.CD-17-1327

Published: 31 May 2018

View article titled, Genetic Mechanisms of Immune Evasion in Colorectal Cancer

Includes: Supplementary data

Journal Articles

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Russell W. Jenkins, Amir R. Aref, Patrick H. Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W. Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A. Kaplan, Andrew Portell, Prafulla C. Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E. Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C. Thai, Marc R. Hammond, Raven Vlahos, Eric S. Wang, Hua Zhang, Shuai Li, Glenn J. Hanna, Wei Huang, Mai P. Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O. Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R. LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M. Cleary, Brian C. Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U. Barbie, Vivek Sivathanu, Joshua Wong, William G. Richards, Raphael Bueno, Charles H. Yoon, Juan Miret, Meenhard Herlyn, Levi A. Garraway, Eliezer M. Van Allen, Gordon J. Freeman, Paul T. Kirschmeier, Jochen H. Lorch, Patrick A. Ott, F. Stephen Hodi, Keith T. Flaherty, Roger D. Kamm, Genevieve M. Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A. Barbie

Cancer Discov (2018) 8 (2): 196–215.

https://doi.org/10.1158/2159-8290.CD-17-0833

Published: 04 February 2018

View article titled, Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Includes: Multimedia, Supplementary data

Journal Articles

Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations

Cancer Discov (2017) 7 (9): 973–983.

https://doi.org/10.1158/2159-8290.CD-16-0960

Published: 31 August 2017

View article titled, Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations

Includes: Supplementary data

Journal Articles

Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer

Xiuning Le, Rajee Antony, Pedram Razavi, Daniel J. Treacy, Flora Luo, Mahmoud Ghandi, Pau Castel, Maurizio Scaltriti, José Baselga, Levi A. Garraway

Cancer Discov (2016) 6 (10): 1134–1147.

https://doi.org/10.1158/2159-8290.CD-16-0305

Published: 02 October 2016

View article titled, Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer

Includes: Supplementary data

Journal Articles

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Cancer Discov (2016) 6 (8): 914–929.

https://doi.org/10.1158/2159-8290.CD-16-0154

Published: 01 August 2016

View article titled, Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Includes: Supplementary data

Journal Articles

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

Cancer Discov (2015) 5 (4): 358–367.

https://doi.org/10.1158/2159-8290.CD-14-1518

Published: 05 April 2015

View article titled, Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

Includes: Supplementary data

Journal Articles

Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

Cancer Discov (2014) 4 (10): 1140–1153.

https://doi.org/10.1158/2159-8290.CD-14-0623

Published: 30 September 2014

View article titled, Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

Includes: Supplementary data

Journal Articles

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

David J. Konieczkowski, Cory M. Johannessen, Omar Abudayyeh, Jong Wook Kim, Zachary A. Cooper, Adriano Piris, Dennie T. Frederick, Michal Barzily-Rokni, Ravid Straussman, Rizwan Haq, David E. Fisher, Jill P. Mesirov, William C. Hahn, Keith T. Flaherty, Jennifer A. Wargo, Pablo Tamayo, Levi A. Garraway

Cancer Discov (2014) 4 (7): 816–827.

https://doi.org/10.1158/2159-8290.CD-13-0424

Published: 06 July 2014

View article titled, A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

Includes: Supplementary data

Journal Articles

Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

Cancer Discov (2014) 4 (5): 546–553.

https://doi.org/10.1158/2159-8290.CD-13-0353

Published: 01 May 2014

View article titled, Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

Includes: Supplementary data

Journal Articles

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Cancer Discov (2014) 4 (1): 94–109.

https://doi.org/10.1158/2159-8290.CD-13-0617

Published: 07 January 2014

View article titled, The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Includes: Supplementary data

Journal Articles

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Cancer Discov (2014) 4 (1): 61–68.

https://doi.org/10.1158/2159-8290.CD-13-0631

Published: 07 January 2014

View article titled, MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Includes: Supplementary data

Journal Articles

Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers

Cancer Discov (2013) 3 (9): 1044–1057.

https://doi.org/10.1158/2159-8290.CD-12-0592

Published: 09 September 2013

View article titled, Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers

Includes: Supplementary data

Journal Articles

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

Cancer Discov (2013) 3 (7): 761–769.

https://doi.org/10.1158/2159-8290.CD-13-0103

Published: 10 July 2013

View article titled, Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

Includes: Supplementary data

Journal Articles

A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

Steven R. Whittaker, Jean-Philippe Theurillat, Eliezer Van Allen, Nikhil Wagle, Jessica Hsiao, Glenn S. Cowley, Dirk Schadendorf, David E. Root, Levi A. Garraway

Cancer Discov (2013) 3 (3): 350–362.

https://doi.org/10.1158/2159-8290.CD-12-0470

Published: 07 March 2013

View article titled, A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

Includes: Supplementary data

Journal Articles

Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

Cancer Discov (2012) 2 (10): 934–947.

https://doi.org/10.1158/2159-8290.CD-12-0103

Published: 14 October 2012

View article titled, Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

Includes: Supplementary data

Journal Articles

Whole-Genome Sequencing and Cancer Therapy: Is Too Much Ever Enough?

Levi A. Garraway, José Baselga

Cancer Discov (2012) 2 (9): 766–768.

https://doi.org/10.1158/2159-8290.CD-12-0359

Published: 10 September 2012

View article titled, Whole-Genome Sequencing and Cancer Therapy: Is Too Much Ever Enough?

Journal Articles

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

Levi A. Garraway, Pasi A. Jänne

Cancer Discov (2012) 2 (3): 214–226.

https://doi.org/10.1158/2159-8290.CD-12-0012

Published: 13 March 2012

View article titled, Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

NARROW

The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer

MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Genetic Mechanisms of Immune Evasion in Colorectal Cancer

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations

Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

A Genome-Scale RNA Interference Screen Implicates NF1 Loss in Resistance to RAF Inhibition

Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

Whole-Genome Sequencing and Cancer Therapy: Is Too Much Ever Enough?

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

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