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Journal Articles

Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection

Peter J. Mazzone, Peter B. Bach, Jacob Carey, Caitlin A. Schonewolf, Katalin Bognar, Manmeet S. Ahluwalia, Marcia Cruz-Correa, David Gierada, Sonali Kotagiri, Kathryn Lloyd, Fabien Maldonado, Jesse D. Ortendahl, Lecia V. Sequist, Gerard A. Silvestri, Nichole Tanner, Jeffrey C. Thompson, Anil Vachani, Kwok-Kin Wong, Ali H. Zaidi, Joseph Catallini, Ariel Gershman, Keith Lumbard, Laurel K. Millberg, Jeff Nawrocki, Carter Portwood, Aakanksha Rangnekar, Carolina Campos Sheridan, Niti Trivedi, Tony Wu, Yuhua Zong, Lindsey Cotton, Allison Ryan, Christopher Cisar, Alessandro Leal, Nicholas Dracopoli, Robert B. Scharpf, Victor E. Velculescu, Luke R. G. Pike
Journal: Cancer Discovery
Cancer Discov OF1–OF19.
https://doi.org/10.1158/2159-8290.CD-24-0519
Published: 23 September 2024
View article titled, Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
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Includes: Supplementary data
Journal Articles

Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor–Mutated, MET-Amplified Non–Small Cell Lung Cancer: TATTON

Ryan J. Hartmaier, Aleksandra A. Markovets, Myung Ju Ahn, Lecia V. Sequist, Ji-Youn Han, Byoung Chul Cho, Helena A. Yu, Sang-We Kim, James Chih-Hsin Yang, Jong-Seok Lee, Wu-Chou Su, Dariusz M. Kowalski, Sergey Orlov, Song Ren, Paul Frewer, Xiaoling Ou, Darren A.E. Cross, Nisha Kurian, Mireille Cantarini, Pasi A. Jänne
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 98–113.
https://doi.org/10.1158/2159-8290.CD-22-0586
Published: 09 January 2023
View article titled, Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor–Mutated, <em>MET</em>-Amplified Non–Small Cell Lung Cancer: TATTON
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Includes: Supplementary data
Journal Articles

Targeting EGFR Exon 20 Insertions in Non–Small Cell Lung Cancer: Recent Advances and Clinical Updates

Catherine B. Meador, Lecia V. Sequist, Zofia Piotrowska
Journal: Cancer Discovery
Cancer Discov (2021) 11 (9): 2145–2157.
https://doi.org/10.1158/2159-8290.CD-21-0226
Published: 01 September 2021
View article titled, Targeting <em>EGFR</em> Exon 20 Insertions in Non–Small Cell Lung Cancer: Recent Advances and Clinical Updates
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Journal Articles

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Anna F. Farago, Beow Y. Yeap, Marcello Stanzione, Yin P. Hung, Rebecca S. Heist, J. Paul Marcoux, Jun Zhong, Deepa Rangachari, David A. Barbie, Sarah Phat, David T. Myers, Robert Morris, Marina Kem, Taronish D. Dubash, Elizabeth A. Kennedy, Subba R. Digumarthy, Lecia V. Sequist, Aaron N. Hata, Shyamala Maheswaran, Daniel A. Haber, Michael S. Lawrence, Alice T. Shaw, Mari Mino-Kenudson, Nicholas J. Dyson, Benjamin J. Drapkin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (10): 1372–1387.
https://doi.org/10.1158/2159-8290.CD-19-0582
Published: 01 October 2019
View article titled, Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion

Zofia Piotrowska, Hideko Isozaki, Jochen K. Lennerz, Justin F. Gainor, Inga T. Lennes, Viola W. Zhu, Nicolas Marcoux, Mandeep K. Banwait, Subba R. Digumarthy, Wenjia Su, Satoshi Yoda, Amanda K. Riley, Varuna Nangia, Jessica J. Lin, Rebecca J. Nagy, Richard B. Lanman, Dora Dias-Santagata, Mari Mino-Kenudson, A. John Iafrate, Rebecca S. Heist, Alice T. Shaw, Erica K. Evans, Corinne Clifford, Sai-Hong I. Ou, Beni Wolf, Aaron N. Hata, Lecia V. Sequist
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (12): 1529–1539.
https://doi.org/10.1158/2159-8290.CD-18-1022
Published: 03 December 2018
View article titled, Landscape of Acquired Resistance to Osimertinib in <em>EGFR</em>-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired <em>RET</em> Fusion
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Includes: Supplementary data
Journal Articles

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non–Small Cell Lung Cancer

Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A. Ferris, Michael Lanuti, Cameron D. Wright, Kevin A. Raskin, Daniel P. Cahill, John H. Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G. Azzoli, Justin F. Gainor, Kristopher A. Sarosiek, Sean P. Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes, Aaron N. Hata
Journal: Cancer Discovery
Cancer Discov (2018) 8 (12): 1598–1613.
https://doi.org/10.1158/2159-8290.CD-18-0277
Published: 03 December 2018
View article titled, Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in <em>KRAS</em>-Mutant Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer

Tanya T. Kwan, Aditya Bardia, Laura M. Spring, Anita Giobbie-Hurder, Mark Kalinich, Taronish Dubash, Tilak Sundaresan, Xin Hong, Joseph A. LiCausi, Uyen Ho, Erin J. Silva, Ben S. Wittner, Lecia V. Sequist, Ravi Kapur, David T. Miyamoto, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (10): 1286–1299.
https://doi.org/10.1158/2159-8290.CD-18-0432
Published: 02 October 2018
View article titled, A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

Benjamin J. Drapkin, Julie George, Camilla L. Christensen, Mari Mino-Kenudson, Ruben Dries, Tilak Sundaresan, Sarah Phat, David T. Myers, Jun Zhong, Peter Igo, Mehlika H. Hazar-Rethinam, Joseph A. Licausi, Maria Gomez-Caraballo, Marina Kem, Kandarp N. Jani, Roxana Azimi, Nima Abedpour, Roopika Menon, Sotirios Lakis, Rebecca S. Heist, Reinhard Büttner, Stefan Haas, Lecia V. Sequist, Alice T. Shaw, Kwok-Kin Wong, Aaron N. Hata, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber, Martin Peifer, Nicholas Dyson, Roman K. Thomas, Anna F. Farago
Journal: Cancer Discovery
Cancer Discov (2018) 8 (5): 600–615.
https://doi.org/10.1158/2159-8290.CD-17-0935
Published: 30 April 2018
View article titled, Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
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Includes: Supplementary data
Journal Articles

An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer

David T. Miyamoto, Richard J. Lee, Mark Kalinich, Joseph A. LiCausi, Yu Zheng, Tianqi Chen, John D. Milner, Erin Emmons, Uyen Ho, Katherine Broderick, Erin Silva, Sarah Javaid, Tanya Todorova Kwan, Xin Hong, Douglas M. Dahl, Francis J. McGovern, Jason A. Efstathiou, Matthew R. Smith, Lecia V. Sequist, Ravi Kapur, Chin-Lee Wu, Shannon L. Stott, David T. Ting, Anita Giobbie-Hurder, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Discovery
Cancer Discov (2018) 8 (3): 288–303.
https://doi.org/10.1158/2159-8290.CD-16-1406
Published: 01 March 2018
View article titled, An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

Justin F. Gainor, Leila Dardaei, Satoshi Yoda, Luc Friboulet, Ignaty Leshchiner, Ryohei Katayama, Ibiayi Dagogo-Jack, Shirish Gadgeel, Katherine Schultz, Manrose Singh, Emily Chin, Melissa Parks, Dana Lee, Richard H. DiCecca, Elizabeth Lockerman, Tiffany Huynh, Jennifer Logan, Lauren L. Ritterhouse, Long P. Le, Ashok Muniappan, Subba Digumarthy, Colleen Channick, Colleen Keyes, Gad Getz, Dora Dias-Santagata, Rebecca S. Heist, Jochen Lennerz, Lecia V. Sequist, Cyril H. Benes, A. John Iafrate, Mari Mino-Kenudson, Jeffrey A. Engelman, Alice T. Shaw
Journal: Cancer Discovery
Cancer Discov (2016) 6 (10): 1118–1133.
https://doi.org/10.1158/2159-8290.CD-16-0596
Published: 02 October 2016
View article titled, Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in <em>ALK</em>-Rearranged Lung Cancer
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Includes: Supplementary data
Journal Articles

Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

Zofia Piotrowska, Matthew J. Niederst, Chris A. Karlovich, Heather A. Wakelee, Joel W. Neal, Mari Mino-Kenudson, Linnea Fulton, Aaron N. Hata, Elizabeth L. Lockerman, Anuj Kalsy, Subba Digumarthy, Alona Muzikansky, Mitch Raponi, Angel R. Garcia, Hillary E. Mulvey, Melissa K. Parks, Richard H. DiCecca, Dora Dias-Santagata, A. John Iafrate, Alice T. Shaw, Andrew R. Allen, Jeffrey A. Engelman, Lecia V. Sequist
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (7): 713–722.
https://doi.org/10.1158/2159-8290.CD-15-0399
Published: 06 July 2015
View article titled, Heterogeneity Underlies the Emergence of <em>EGFR</em><sup>T790</sup> Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor
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Includes: Supplementary data
Journal Articles

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

James P. Sullivan, Brian V. Nahed, Marissa W. Madden, Samantha M. Oliveira, Simeon Springer, Deepak Bhere, Andrew S. Chi, Hiroaki Wakimoto, S. Michael Rothenberg, Lecia V. Sequist, Ravi Kapur, Khalid Shah, A. John Iafrate, William T. Curry, Jay S. Loeffler, Tracy T. Batchelor, David N. Louis, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Discovery
Cancer Discov (2014) 4 (11): 1299–1309.
https://doi.org/10.1158/2159-8290.CD-14-0471
Published: 01 November 2014
View article titled, Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression
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Includes: Supplementary data
Journal Articles

Androgen Receptor Signaling in Circulating Tumor Cells as a Marker of Hormonally Responsive Prostate Cancer

David T. Miyamoto, Richard J. Lee, Shannon L. Stott, David T. Ting, Ben S. Wittner, Matthew Ulman, Malgorzata E. Smas, Jenna B. Lord, Brian W. Brannigan, Julie Trautwein, Neil H. Bander, Chin-Lee Wu, Lecia V. Sequist, Matthew R. Smith, Sridhar Ramaswamy, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Discovery
Cancer Discov (2012) 2 (11): 995–1003.
https://doi.org/10.1158/2159-8290.CD-12-0222
Published: 11 November 2012
View article titled, Androgen Receptor Signaling in Circulating Tumor Cells as a Marker of Hormonally Responsive Prostate Cancer
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Includes: Supplementary data
Journal Articles

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers

Hiu Wing Cheung, Jinyan Du, Jesse S. Boehm, Frank He, Barbara A. Weir, Xiaoxing Wang, Mohit Butaney, Lecia V. Sequist, Biao Luo, Jeffrey A. Engelman, David E. Root, Matthew Meyerson, Todd R. Golub, Pasi A. Jänne, William C. Hahn
Journal: Cancer Discovery
Cancer Discov (2011) 1 (7): 608–625.
https://doi.org/10.1158/2159-8290.CD-11-0046
Published: 13 December 2011
View article titled, Amplification of <em>CRKL</em> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers
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Includes: Supplementary data
Journal Articles

BIM Expression in Treatment-Naïve Cancers Predicts Responsiveness to Kinase Inhibitors

Anthony C. Faber, Ryan B. Corcoran, Hiromichi Ebi, Lecia V. Sequist, Belinda A. Waltman, Euiheon Chung, Joao Incio, Subba R. Digumarthy, Sarah F. Pollack, Youngchul Song, Alona Muzikansky, Eugene Lifshits, Sylvie Roberge, Erik J. Coffman, Cyril H. Benes, Henry L. Gómez, José Baselga, Carlos L. Arteaga, Miguel N. Rivera, Dora Dias-Santagata, Rakesh K. Jain, Jeffrey A. Engelman
Journal: Cancer Discovery
Cancer Discov (2011) 1 (4): 352–365.
https://doi.org/10.1158/2159-8290.CD-11-0106
Published: 14 September 2011
View article titled, BIM Expression in Treatment-Naïve Cancers Predicts Responsiveness to Kinase Inhibitors
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Includes: Multimedia, Supplementary data
Journal Articles

A New BATTLE in the Evolving War on Cancer

Lecia V. Sequist, Alona Muzikansky, Jeffrey A. Engelman
Journal: Cancer Discovery
Cancer Discov (2011) 1 (1): 14–16.
https://doi.org/10.1158/2159-8274.CD-11-0044
Published: 01 June 2011
View article titled, A New BATTLE in the Evolving War on Cancer
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