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Leanne G. Ahronian
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Journal Articles

Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAFV600E Colorectal Cancer

Mehlika Hazar-Rethinam, Marianna Kleyman, G. Celine Han, David Liu, Leanne G. Ahronian, Heather A. Shahzade, Lifeng Chen, Aparna R. Parikh, Jill N. Allen, Jeffrey W. Clark, Eunice L. Kwak, Jason E. Faris, Janet E. Murphy, Theodore S. Hong, Emily E. Van Seventer, Brandon Nadres, Catriona B. Hong, Joseph M. Gurski, Jr, Nicholas A. Jessop, Dora Dias-Santagata, A. John Iafrate, Eliezer M. Van Allen, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (4): 417–427.
https://doi.org/10.1158/2159-8290.CD-17-1227
Published: 01 April 2018
View article titled, Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in <em>BRAF</em><sup>V600E</sup> Colorectal Cancer
Open the PDF for Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in <em>BRAF</em><sup>V600E</sup> Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer

John H. Strickler, Jonathan M. Loree, Leanne G. Ahronian, Aparna R. Parikh, Donna Niedzwiecki, Allan Andresson Lima Pereira, Matthew McKinney, W. Michael Korn, Chloe E. Atreya, Kimberly C. Banks, Rebecca J. Nagy, Funda Meric-Bernstam, Richard B. Lanman, AmirAli Talasaz, Igor F. Tsigelny, Ryan B. Corcoran, Scott Kopetz
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (2): 164–173.
https://doi.org/10.1158/2159-8290.CD-17-1009
Published: 04 February 2018
View article titled, Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer
Open the PDF for Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma

Lipika Goyal, Supriya K. Saha, Leah Y. Liu, Giulia Siravegna, Ignaty Leshchiner, Leanne G. Ahronian, Jochen K. Lennerz, Phuong Vu, Vikram Deshpande, Avinash Kambadakone, Benedetta Mussolin, Stephanie Reyes, Laura Henderson, Jiaoyuan Elisabeth Sun, Emily E. Van Seventer, Joseph M. Gurski, Jr, Sabrina Baltschukat, Barbara Schacher-Engstler, Louise Barys, Christelle Stamm, Pascal Furet, David P. Ryan, James R. Stone, A. John Iafrate, Gad Getz, Diana Graus Porta, Ralph Tiedt, Alberto Bardelli, Dejan Juric, Ryan B. Corcoran, Nabeel Bardeesy, Andrew X. Zhu
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (3): 252–263.
https://doi.org/10.1158/2159-8290.CD-16-1000
Published: 05 March 2017
View article titled, Polyclonal Secondary <em>FGFR2</em> Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma
Open the PDF for Polyclonal Secondary <em>FGFR2</em> Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

Mariangela Russo, Giulia Siravegna, Lawrence S. Blaszkowsky, Giorgio Corti, Giovanni Crisafulli, Leanne G. Ahronian, Benedetta Mussolin, Eunice L. Kwak, Michela Buscarino, Luca Lazzari, Emanuele Valtorta, Mauro Truini, Nicholas A. Jessop, Hayley E. Robinson, Theodore S. Hong, Mari Mino-Kenudson, Federica Di Nicolantonio, Ashraf Thabet, Andrea Sartore-Bianchi, Salvatore Siena, A. John Iafrate, Alberto Bardelli, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 147–153.
https://doi.org/10.1158/2159-8290.CD-15-1283
Published: 04 February 2016
View article titled, Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer
Open the PDF for Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer

Eunice L. Kwak, Leanne G. Ahronian, Giulia Siravegna, Benedetta Mussolin, Darrell R. Borger, Jason T. Godfrey, Nicholas A. Jessop, Jeffrey W. Clark, Lawrence S. Blaszkowsky, David P. Ryan, Jochen K. Lennerz, A. John Iafrate, Alberto Bardelli, Theodore S. Hong, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (12): 1271–1281.
https://doi.org/10.1158/2159-8290.CD-15-0748
Published: 03 December 2015
View article titled, Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in <em>MET</em>-Amplified Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

Leanne G. Ahronian, Erin M. Sennott, Eliezer M. Van Allen, Nikhil Wagle, Eunice L. Kwak, Jason E. Faris, Jason T. Godfrey, Koki Nishimura, Kerry D. Lynch, Craig H. Mermel, Elizabeth L. Lockerman, Anuj Kalsy, Joseph M. Gurski, Jr, Samira Bahl, Kristin Anderka, Lisa M. Green, Niall J. Lennon, Tiffany G. Huynh, Mari Mino-Kenudson, Gad Getz, Dora Dias-Santagata, A. John Iafrate, Jeffrey A. Engelman, Levi A. Garraway, Ryan B. Corcoran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (4): 358–367.
https://doi.org/10.1158/2159-8290.CD-14-1518
Published: 05 April 2015
View article titled, Clinical Acquired Resistance to RAF Inhibitor Combinations in <em>BRAF</em>-Mutant Colorectal Cancer through MAPK Pathway Alterations
Open the PDF for Clinical Acquired Resistance to RAF Inhibitor Combinations in <em>BRAF</em>-Mutant Colorectal Cancer through MAPK Pathway Alterations in another window
Includes: Supplementary data