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Kimberly Stegmaier
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Journal Articles

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria C. Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V. Dharia, Deyao Li, Samantha E. Hoffman, Guillaume Kugener, McKenzie L. Shaw, Hafsa M. Mire, Olivia A. Hack, Joshua M. Dempster, Caleb Lareau, Lingling Dai, Logan H. Sigua, Michael A. Quezada, Ann-Catherine J. Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vazquez, Federica Piccioni, John G. Doench, David E. Root, Jamie N. Anastas, Kristen L. Jones, Amy Saur Conway, Sylwia Stopka, Michael S. Regan, Yu Liang, Hyuk-Soo Seo, Kijun Song, Puspalata Bashyal, William P. Jerome, Nathan D. Mathewson, Sirano Dhe-Paganon, Mario L. Suvà, Angel M. Carcaboso, Cinzia Lavarino, Jaume Mora, Quang-De Nguyen, Keith L. Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y.R. Agar, Kimberly Stegmaier, Charles D. Stiles, Michelle Monje, Todd R. Golub, Jun Qi, Mariella G. Filbin
Journal: Cancer Discovery
Cancer Discov (2022) 12 (12): 2880–2905.
https://doi.org/10.1158/2159-8290.CD-21-1491
Published: 02 December 2022
View article titled, BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
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Includes: Supplementary data
Journal Articles

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts

Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda S. Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Saur Conway, Delan Khalid, Jennifer A. Perry, Mark Wunderlich, Lina Benajiba, Yana Pikman, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2022) 12 (7): 1760–1781.
https://doi.org/10.1158/2159-8290.CD-21-0956
Published: 06 July 2022
View article titled, Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
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Includes: Supplementary data
Journal Articles

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M. Shendy, Stephanie Nance, Anand G. Patel, Ying Shao, Maya Mundada, Lily Maxham, Paul M.C. Park, Logan H. Sigua, Ken Morita, Amy Saur Conway, Amanda L. Robichaud, Antonio R. Perez-Atayde, Melissa J. Bikowitz, Taylor R. Quinn, Olaf Wiest, John Easton, Ernst Schönbrunn, Martha L. Bulyk, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi
Journal: Cancer Discovery
Cancer Discov (2022) 12 (3): 730–751.
https://doi.org/10.1158/2159-8290.CD-21-0385
Published: 01 March 2022
View article titled, EP300 Selectively Controls the Enhancer Landscape of <em>MYCN</em>-Amplified Neuroblastoma
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Includes: Supplementary data
Journal Articles

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

Shan Lin, Clément Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh V. Dharia, Miljan Kuljanin, Caroline S. Wechsler, Guillaume Kugener, Amanda L. Robichaud, Amy Saur Conway, Thelma Mashaka, Sarah Mouche, Biniam Adane, Jeremy A. Ryan, Joseph D. Mancias, Scott T. Younger, Federica Piccioni, Lynn H. Lee, Mark Wunderlich, Anthony Letai, Jérôme Tamburini, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 432–449.
https://doi.org/10.1158/2159-8290.CD-20-1851
Published: 01 February 2022
View article titled, An <em>In Vivo</em> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
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Includes: Supplementary data
Journal Articles

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Clare F. Malone, Neekesh V. Dharia, Guillaume Kugener, Alexandra B. Forman, Michael V. Rothberg, Mai Abdusamad, Alfredo Gonzalez, Miljan Kuljanin, Amanda L. Robichaud, Amy Saur Conway, Joshua M. Dempster, Brenton R. Paolella, Nancy Dumont, Volker Hovestadt, Joseph D. Mancias, Scott T. Younger, David E. Root, Todd R. Golub, Francisca Vazquez, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2021) 11 (9): 2282–2299.
https://doi.org/10.1158/2159-8290.CD-20-1213
Published: 01 September 2021
View article titled, Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer
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Includes: Supplementary data
Journal Articles

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium

Yana Pikman, Sarah K. Tasian, Maria Luisa Sulis, Kristen Stevenson, Traci M. Blonquist, Beth Apsel Winger, Todd M. Cooper, Melinda Pauly, Kelly W. Maloney, Michael J. Burke, Patrick A. Brown, Nathan Gossai, Jennifer L. McNeer, Neerav N. Shukla, Peter D. Cole, Justine M. Kahn, Jing Chen, Matthew J. Barth, Jeffrey A. Magee, Lisa Gennarini, Asmani A. Adhav, Catherine M. Clinton, Nicole Ocasio-Martinez, Giacomo Gotti, Yuting Li, Shan Lin, Alma Imamovic, Cristina E. Tognon, Tasleema Patel, Haley L. Faust, Cristina F. Contreras, Anjali Cremer, Wilian A. Cortopassi, Diego Garrido Ruiz, Matthew P. Jacobson, Neekesh V. Dharia, Angela Su, Amanda L. Robichaud, Amy Saur Conway, Katherine Tarlock, Elliot Stieglitz, Andrew E. Place, Alexandre Puissant, Stephen P. Hunger, Annette S. Kim, Neal I. Lindeman, Lia Gore, Katherine A. Janeway, Lewis B. Silverman, Jeffrey W. Tyner, Marian H. Harris, Mignon L. Loh, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1424–1439.
https://doi.org/10.1158/2159-8290.CD-20-0564
Published: 01 June 2021
View article titled, Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium
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Includes: Supplementary data
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Dombret, Claude Preudhomme, Nina Fenouille, Lina Benajiba, Hava M. Golan, Kimberly Stegmaier, Camille Lobry, Kris C. Wood, Raphael Itzykson, Alexandre Puissant
Journal: Cancer Discovery
Cancer Discov (2020) 10 (12): 1894–1911.
https://doi.org/10.1158/2159-8290.CD-19-0970
Published: 01 December 2020
View article titled, The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
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Includes: Supplementary data
Journal Articles

Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

Anjali Cremer, Jana M. Ellegast, Gabriela Alexe, Elizabeth S. Frank, Linda Ross, S. Haihua Chu, Yana Pikman, Amanda Robichaud, Amy Goodale, Björn Häupl, Sebastian Mohr, Arati V. Rao, Alison R. Walker, James S. Blachly, Federica Piccioni, Scott A. Armstrong, John C. Byrd, Thomas Oellerich, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2020) 10 (2): 214–231.
https://doi.org/10.1158/2159-8290.CD-19-0209
Published: 05 February 2020
View article titled, Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

Riadh Lobbardi, Jordan Pinder, Barbara Martinez-Pastor, Marina Theodorou, Jessica S. Blackburn, Brian J. Abraham, Yuka Namiki, Marc Mansour, Nouran S. Abdelfattah, Aleksey Molodtsov, Gabriela Alexe, Debra Toiber, Manon de Waard, Esha Jain, Myriam Boukhali, Mattia Lion, Deepak Bhere, Khalid Shah, Alejandro Gutierrez, Kimberly Stegmaier, Lewis B. Silverman, Ruslan I. Sadreyev, John M. Asara, Marjorie A. Oettinger, Wilhelm Haas, A. Thomas Look, Richard A. Young, Raul Mostoslavsky, Graham Dellaire, David M. Langenau
Journal: Cancer Discovery
Cancer Discov (2017) 7 (11): 1336–1353.
https://doi.org/10.1158/2159-8290.CD-17-0267
Published: 01 November 2017
View article titled, TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Andrew J. Aguirre, Robin M. Meyers, Barbara A. Weir, Francisca Vazquez, Cheng-Zhong Zhang, Uri Ben-David, April Cook, Gavin Ha, William F. Harrington, Mihir B. Doshi, Maria Kost-Alimova, Stanley Gill, Han Xu, Levi D. Ali, Guozhi Jiang, Sasha Pantel, Yenarae Lee, Amy Goodale, Andrew D. Cherniack, Coyin Oh, Gregory Kryukov, Glenn S. Cowley, Levi A. Garraway, Kimberly Stegmaier, Charles W. Roberts, Todd R. Golub, Matthew Meyerson, David E. Root, Aviad Tsherniak, William C. Hahn
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (8): 914–929.
https://doi.org/10.1158/2159-8290.CD-16-0154
Published: 01 August 2016
View article titled, Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
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Includes: Supplementary data
Journal Articles

The Genomic Landscape of Pediatric Ewing Sarcoma

Brian D. Crompton, Chip Stewart, Amaro Taylor-Weiner, Gabriela Alexe, Kyle C. Kurek, Monica L. Calicchio, Adam Kiezun, Scott L. Carter, Sachet A. Shukla, Swapnil S. Mehta, Aaron R. Thorner, Carmen de Torres, Cinzia Lavarino, Mariona Suñol, Aaron McKenna, Andrey Sivachenko, Kristian Cibulskis, Michael S. Lawrence, Petar Stojanov, Mara Rosenberg, Lauren Ambrogio, Daniel Auclair, Sara Seepo, Brendan Blumenstiel, Matthew DeFelice, Ivan Imaz-Rosshandler, Angela Schwarz-Cruz y Celis, Miguel N. Rivera, Carlos Rodriguez-Galindo, Mark D. Fleming, Todd R. Golub, Gad Getz, Jaume Mora, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2014) 4 (11): 1326–1341.
https://doi.org/10.1158/2159-8290.CD-13-1037
Published: 01 November 2014
View article titled, The Genomic Landscape of Pediatric Ewing Sarcoma
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Includes: Supplementary data
Journal Articles

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Alexandre Puissant, Stacey M. Frumm, Gabriela Alexe, Christopher F. Bassil, Jun Qi, Yvan H. Chanthery, Erin A. Nekritz, Rhamy Zeid, William Clay Gustafson, Patricia Greninger, Matthew J. Garnett, Ultan McDermott, Cyril H. Benes, Andrew L. Kung, William A. Weiss, James E. Bradner, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 308–323.
https://doi.org/10.1158/2159-8290.CD-12-0418
Published: 07 March 2013
View article titled, Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
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Includes: Supplementary data