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Kevan M. Shokat
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Journal Articles

A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability

Open Access
Keelan Z. Guiley, Kevan M. Shokat
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 56–69.
https://doi.org/10.1158/2159-8290.CD-22-0381
Published: 09 January 2023
View article titled, A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability
Open the PDF for A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability in another window
Includes: Supplementary data
Journal Articles

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

Free
Supriya K. Saha, John D. Gordan, Benjamin P. Kleinstiver, Phuong Vu, Mortada S. Najem, Jia-Chi Yeo, Lei Shi, Yasutaka Kato, Rebecca S. Levin, James T. Webber, Leah J. Damon, Regina K. Egan, Patricia Greninger, Ultan McDermott, Mathew J. Garnett, Roger L. Jenkins, Kimberly M. Rieger-Christ, Travis B. Sullivan, Aram F. Hezel, Andrew S. Liss, Yusuke Mizukami, Lipika Goyal, Cristina R. Ferrone, Andrew X. Zhu, J. Keith Joung, Kevan M. Shokat, Cyril H. Benes, Nabeel Bardeesy
Journal: Cancer Discovery
Cancer Discov (2016) 6 (7): 727–739.
https://doi.org/10.1158/2159-8290.CD-15-1442
Published: 30 June 2016
View article titled, Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma
Open the PDF for Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map

Free
Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakhshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan F. Shamji, Stuart L. Schreiber, Nevan J. Krogan, Kevan M. Shokat, Frank McCormick, Andrei Goga, Sourav Bandyopadhyay
Journal: Cancer Discovery
Cancer Discov (2015) 5 (2): 154–167.
https://doi.org/10.1158/2159-8290.CD-14-0552
Published: 04 February 2015
View article titled, Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map
Open the PDF for Linking Tumor Mutations to Drug Responses via a Quantitative Chemical–Genetic Interaction Map in another window
Includes: Supplementary data
Journal Articles

Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers

Free
Krister J. Barkovich, Sujatmi Hariono, Adam L. Garske, Jie Zhang, Jimmy A. Blair, Qi-Wen Fan, Kevan M. Shokat, Theodore Nicolaides, William A. Weiss
Journal: Cancer Discovery
Cancer Discov (2012) 2 (5): 450–457.
https://doi.org/10.1158/2159-8290.CD-11-0287
Published: 09 May 2012
View article titled, Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers
Open the PDF for Kinetics of Inhibitor Cycling Underlie Therapeutic Disparities between EGFR-Driven Lung and Brain Cancers in another window
Includes: Supplementary data