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Karen E. Knudsen
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Journal Articles

Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

Sandra Santasusagna, Shijia Zhu, Vijayakumar Jawalagatti, Marc Carceles-Cordon, Adam Ertel, Saioa Garcia-Longarte, Won-Min Song, Naoto Fujiwara, Peiyao Li, Isabel Mendizabal, Daniel P. Petrylak, William Kevin Kelly, E. Premkumar Reddy, Liguo Wang, Matthew J. Schiewer, Amaia Lujambio, Jeffrey Karnes, Karen E. Knudsen, Carlos Cordon-Cardo, Haidong Dong, Haojie Huang, Arkaitz Carracedo, Yujin Hoshida, Veronica Rodriguez-Bravo, Josep Domingo-Domenech
Journal: Cancer Discovery
Cancer Discov (2023) 13 (12): 2584–2609.
https://doi.org/10.1158/2159-8290.CD-23-0306
Published: 12 December 2023
View articletitled, Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease

Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J. McCann, Talya S. Laufer, Nicolas Gordon, Irina A. Vasilevskaya, Emanuela Dylgjeri, Saswati N. Chand, Matthew J. Schiewer, Josep Domingo-Domenech, Robert B. Den, Jeff Holst, Peter A. McCue, Johann S. de Bono, Christopher McNair, Karen E. Knudsen
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (9): 2334–2353.
https://doi.org/10.1158/2159-8290.CD-20-1114
Published: 01 September 2021
View articletitled, RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease
Open the PDF for RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease in another window
Includes: Supplementary data
Journal Articles

Targeting the p300/CBP Axis in Lethal Prostate Cancer

Jonathan Welti, Adam Sharp, Nigel Brooks, Wei Yuan, Christopher McNair, Saswati N. Chand, Abhijit Pal, Ines Figueiredo, Ruth Riisnaes, Bora Gurel, Jan Rekowski, Denisa Bogdan, William West, Barbara Young, Meera Raja, Amy Prosser, Jordan Lane, Stuart Thomson, Jenny Worthington, Stuart Onions, Jonathan Shannon, Silvia Paoletta, Richard Brown, Don Smyth, Gareth W. Harbottle, Veronica S. Gil, Susana Miranda, Mateus Crespo, Ana Ferreira, Rita Pereira, Nina Tunariu, Suzanne Carreira, Antje J. Neeb, Jian Ning, Amanda Swain, David Taddei, SU2C/PCF International Prostate Cancer Dream Team, Matthew J. Schiewer, Karen E. Knudsen, Neil Pegg, Johann S. de Bono
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (5): 1118–1137.
https://doi.org/10.1158/2159-8290.CD-20-0751
Published: 01 May 2021
View articletitled, Targeting the p300/CBP Axis in Lethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

Beyond DNA Repair: DNA-PK Function in Cancer

Jonathan F. Goodwin, Karen E. Knudsen
Journal: Cancer Discovery
Cancer Discov (2014) 4 (10): 1126–1139.
https://doi.org/10.1158/2159-8290.CD-14-0358
Published: 30 September 2014
View articletitled, Beyond DNA Repair: DNA-PK Function in Cancer
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Journal Articles

A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult

Jonathan F. Goodwin, Matthew J. Schiewer, Jeffry L. Dean, Randy S. Schrecengost, Renée de Leeuw, Sumin Han, Teng Ma, Robert B. Den, Adam P. Dicker, Felix Y. Feng, Karen E. Knudsen
Journal: Cancer Discovery
Cancer Discov (2013) 3 (11): 1254–1271.
https://doi.org/10.1158/2159-8290.CD-13-0108
Published: 06 November 2013
View articletitled, A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Open the PDF for A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult in another window
Includes: Supplementary data
Journal Articles

Dual Roles of PARP-1 Promote Cancer Growth and Progression

Matthew J. Schiewer, Jonathan F. Goodwin, Sumin Han, J. Chad Brenner, Michael A. Augello, Jeffry L. Dean, Fengzhi Liu, Jamie L. Planck, Preethi Ravindranathan, Arul M. Chinnaiyan, Peter McCue, Leonard G. Gomella, Ganesh V. Raj, Adam P. Dicker, Jonathan R. Brody, John M. Pascal, Margaret M. Centenera, Lisa M. Butler, Wayne D. Tilley, Felix Y. Feng, Karen E. Knudsen
Journal: Cancer Discovery
Cancer Discov (2012) 2 (12): 1134–1149.
https://doi.org/10.1158/2159-8290.CD-12-0120
Published: 09 December 2012
View articletitled, Dual Roles of PARP-1 Promote Cancer Growth and Progression
Open the PDF for Dual Roles of PARP-1 Promote Cancer Growth and Progression in another window
Includes: Supplementary data