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Journal Articles

DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming

Ilaria Gritti, Jinkai Wan, Vajira Weeresekara, Joel M. Vaz, Giuseppe Tarantino, Tenna Holgersen Bryde, Vindhya Vijay, Ashwin V. Kammula, Prabhat Kattel, Songli Zhu, Phuong Vu, Marina Chan, Meng-Ju Wu, John D. Gordan, Krushna C. Patra, Vanessa S. Silveira, Robert T. Manguso, Marc N. Wein, Christopher J. Ott, Jun Qi, David Liu, Kei Sakamoto, Taranjit S. Gujral, Nabeel Bardeesy
Journal: Cancer Discovery
Cancer Discov (2025) 15 (2): 382–400.
https://doi.org/10.1158/2159-8290.CD-24-0634
Published: 07 February 2025
View article titled, DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming
Open the PDF for DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming in another window
Includes: Supplementary data
Journal Articles

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria C. Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V. Dharia, Deyao Li, Samantha E. Hoffman, Guillaume Kugener, McKenzie L. Shaw, Hafsa M. Mire, Olivia A. Hack, Joshua M. Dempster, Caleb Lareau, Lingling Dai, Logan H. Sigua, Michael A. Quezada, Ann-Catherine J. Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vazquez, Federica Piccioni, John G. Doench, David E. Root, Jamie N. Anastas, Kristen L. Jones, Amy Saur Conway, Sylwia Stopka, Michael S. Regan, Yu Liang, Hyuk-Soo Seo, Kijun Song, Puspalata Bashyal, William P. Jerome, Nathan D. Mathewson, Sirano Dhe-Paganon, Mario L. Suvà, Angel M. Carcaboso, Cinzia Lavarino, Jaume Mora, Quang-De Nguyen, Keith L. Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y.R. Agar, Kimberly Stegmaier, Charles D. Stiles, Michelle Monje, Todd R. Golub, Jun Qi, Mariella G. Filbin
Journal: Cancer Discovery
Cancer Discov (2022) 12 (12): 2880–2905.
https://doi.org/10.1158/2159-8290.CD-21-1491
Published: 02 December 2022
View article titled, BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
Open the PDF for BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma in another window
Includes: Supplementary data
Journal Articles

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M. Shendy, Stephanie Nance, Anand G. Patel, Ying Shao, Maya Mundada, Lily Maxham, Paul M.C. Park, Logan H. Sigua, Ken Morita, Amy Saur Conway, Amanda L. Robichaud, Antonio R. Perez-Atayde, Melissa J. Bikowitz, Taylor R. Quinn, Olaf Wiest, John Easton, Ernst Schönbrunn, Martha L. Bulyk, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi
Journal: Cancer Discovery
Cancer Discov (2022) 12 (3): 730–751.
https://doi.org/10.1158/2159-8290.CD-21-0385
Published: 01 March 2022
View article titled, EP300 Selectively Controls the Enhancer Landscape of <em>MYCN</em>-Amplified Neuroblastoma
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Includes: Supplementary data
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Dombret, Claude Preudhomme, Nina Fenouille, Lina Benajiba, Hava M. Golan, Kimberly Stegmaier, Camille Lobry, Kris C. Wood, Raphael Itzykson, Alexandre Puissant
Journal: Cancer Discovery
Cancer Discov (2020) 10 (12): 1894–1911.
https://doi.org/10.1158/2159-8290.CD-19-0970
Published: 01 December 2020
View article titled, The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
Open the PDF for The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies in another window
Includes: Supplementary data
Journal Articles

In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

Fei Li, Qingyuan Huang, Troy A. Luster, Hai Hu, Hua Zhang, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Wei Wang, Ting Chen, Jiehui Deng, Michela Ranieri, Zhaoyuan Fang, Val Pyon, Catríona M. Dowling, Ece Bagdatlioglu, Christina Almonte, Kristen Labbe, Heather Silver, Alexandra R. Rabin, Kandarp Jani, Aristotelis Tsirigos, Thales Papagiannakopoulos, Peter S. Hammerman, Vamsidhar Velcheti, Gordon J. Freeman, Jun Qi, George Miller, Kwok-Kin Wong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (2): 270–287.
https://doi.org/10.1158/2159-8290.CD-19-0780
Published: 05 February 2020
View article titled, <em>In Vivo</em> Epigenetic CRISPR Screen Identifies <em>Asf1a</em> as an Immunotherapeutic Target in <em>Kras</em>-Mutant Lung Adenocarcinoma
Open the PDF for <em>In Vivo</em> Epigenetic CRISPR Screen Identifies <em>Asf1a</em> as an Immunotherapeutic Target in <em>Kras</em>-Mutant Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Chronic Myelogenous Leukemia– Initiating Cells Require Polycomb Group Protein EZH2

Huafeng Xie, Cong Peng, Jialiang Huang, Bin E. Li, Woojin Kim, Elenoe C. Smith, Yuko Fujiwara, Jun Qi, Giulia Cheloni, Partha P. Das, Minh Nguyen, Shaoguang Li, James E. Bradner, Stuart H. Orkin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (11): 1237–1247.
https://doi.org/10.1158/2159-8290.CD-15-1439
Published: 01 November 2016
View article titled, Chronic Myelogenous Leukemia– Initiating Cells Require Polycomb Group Protein EZH2
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Includes: Supplementary data
Journal Articles

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer

Haikuo Zhang, Jun Qi, Jaime M. Reyes, Lewyn Li, Prakash K. Rao, Fugen Li, Charles Y. Lin, Jennifer A. Perry, Matthew A. Lawlor, Alexander Federation, Thomas De Raedt, Yvonne Y. Li, Yan Liu, Melissa A. Duarte, Yanxi Zhang, Grit S. Herter-Sprie, Eiki Kikuchi, Julian Carretero, Charles M. Perou, Jacob B. Reibel, Joshiawa Paulk, Roderick T. Bronson, Hideo Watanabe, Christine Fillmore Brainson, Carla F. Kim, Peter S. Hammerman, Myles Brown, Karen Cichowski, Henry Long, James E. Bradner, Kwok-Kin Wong
Journal: Cancer Discovery
Cancer Discov (2016) 6 (9): 1006–1021.
https://doi.org/10.1158/2159-8290.CD-16-0164
Published: 31 August 2016
View article titled, Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer
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Includes: Supplementary data
Journal Articles

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

Anjali Mishra, Krista La Perle, Sonya Kwiatkowski, Laura A. Sullivan, Gregory H. Sams, Jessica Johns, Douglas P. Curphey, Jing Wen, Kathleen McConnell, Jun Qi, Henry Wong, Giandomenico Russo, Jianying Zhang, Guido Marcucci, James E. Bradner, Pierluigi Porcu, Michael A. Caligiuri
Journal: Cancer Discovery
Cancer Discov (2016) 6 (9): 986–1005.
https://doi.org/10.1158/2159-8290.CD-15-1297
Published: 31 August 2016
View article titled, Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma
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Includes: Supplementary data
Journal Articles

RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten-Mutant Metastasis

Hyejin Cho, Tali Herzka, Wu Zheng, Jun Qi, John E. Wilkinson, James E. Bradner, Brian D. Robinson, Mireia Castillo-Martin, Carlos Cordon-Cardo, Lloyd C. Trotman
Journal: Cancer Discovery
Cancer Discov (2014) 4 (3): 318–333.
https://doi.org/10.1158/2159-8290.CD-13-0346
Published: 03 March 2014
View article titled, RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of <em>Pten</em>-Mutant Metastasis
Open the PDF for RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of <em>Pten</em>-Mutant Metastasis in another window
Includes: Supplementary data
Journal Articles

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Alexandre Puissant, Stacey M. Frumm, Gabriela Alexe, Christopher F. Bassil, Jun Qi, Yvan H. Chanthery, Erin A. Nekritz, Rhamy Zeid, William Clay Gustafson, Patricia Greninger, Matthew J. Garnett, Ultan McDermott, Cyril H. Benes, Andrew L. Kung, William A. Weiss, James E. Bradner, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 308–323.
https://doi.org/10.1158/2159-8290.CD-12-0418
Published: 07 March 2013
View article titled, Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
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Includes: Supplementary data