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Jos Jonkers
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Journal Articles

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

Constantia Pantelidou, Olmo Sonzogni, Mateus De Oliveria Taveira, Anita K. Mehta, Aditi Kothari, Dan Wang, Tanvi Visal, Michelle K. Li, Jocelin Pinto, Jessica A. Castrillon, Emily M. Cheney, Peter Bouwman, Jos Jonkers, Sven Rottenberg, Jennifer L. Guerriero, Gerburg M. Wulf, Geoffrey I. Shapiro
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (6): 722–737.
https://doi.org/10.1158/2159-8290.CD-18-1218
Published: 03 June 2019
View article titled, PARP Inhibitor Efficacy Depends on CD8<sup>+</sup> T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer
Open the PDF for PARP Inhibitor Efficacy Depends on CD8<sup>+</sup> T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N. Pemberton, Jessica Frankum, Feifei Song, Rumana Rafiq, Asha Konde, Dragomir B. Krastev, Malini Menon, James Campbell, Aditi Gulati, Rahul Kumar, Stephen J. Pettitt, Mark D. Gurden, Marta Llorca Cardenosa, Irene Chong, Patrycja Gazinska, Fredrik Wallberg, Elinor J. Sawyer, Lesley-Ann Martin, Mitch Dowsett, Spiros Linardopoulos, Rachael Natrajan, Colm J. Ryan, Patrick W.B. Derksen, Jos Jonkers, Andrew N.J. Tutt, Alan Ashworth, Christopher J. Lord
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (4): 498–515.
https://doi.org/10.1158/2159-8290.CD-17-0603
Published: 01 April 2018
View article titled, E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
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Includes: Multimedia, Supplementary data
Journal Articles

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Manuel Hidalgo, Frederic Amant, Andrew V. Biankin, Eva Budinská, Annette T. Byrne, Carlos Caldas, Robert B. Clarke, Steven de Jong, Jos Jonkers, Gunhild Mari Mælandsmo, Sergio Roman-Roman, Joan Seoane, Livio Trusolino, Alberto Villanueva, for the EurOPDX Consortium
Journal: Cancer Discovery
Cancer Discov (2014) 4 (9): 998–1013.
https://doi.org/10.1158/2159-8290.CD-14-0001
Published: 01 September 2014
View article titled, Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
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Includes: Supplementary data
Journal Articles

A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants

Peter Bouwman, Hanneke van der Gulden, Ingrid van der Heijden, Rinske Drost, Christiaan N. Klijn, Pramudita Prasetyanti, Mark Pieterse, Ellen Wientjens, Jost Seibler, Frans B.L. Hogervorst, Jos Jonkers
Journal: Cancer Discovery
Cancer Discov (2013) 3 (10): 1142–1155.
https://doi.org/10.1158/2159-8290.CD-13-0094
Published: 10 October 2013
View article titled, A High-Throughput Functional Complementation Assay for Classification of <em>BRCA1</em> Missense Variants
Open the PDF for A High-Throughput Functional Complementation Assay for Classification of <em>BRCA1</em> Missense Variants in another window
Includes: Supplementary data
Journal Articles

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors

Janneke E. Jaspers, Ariena Kersbergen, Ute Boon, Wendy Sol, Liesbeth van Deemter, Serge A. Zander, Rinske Drost, Ellen Wientjens, Jiuping Ji, Amal Aly, James H. Doroshow, Aaron Cranston, Niall M.B. Martin, Alan Lau, Mark J. O'Connor, Shridar Ganesan, Piet Borst, Jos Jonkers, Sven Rottenberg
Journal: Cancer Discovery
Cancer Discov (2013) 3 (1): 68–81.
https://doi.org/10.1158/2159-8290.CD-12-0049
Published: 13 January 2013
View article titled, Loss of 53BP1 Causes PARP Inhibitor Resistance in <em>Brca1</em>-Mutated Mouse Mammary Tumors
Open the PDF for Loss of 53BP1 Causes PARP Inhibitor Resistance in <em>Brca1</em>-Mutated Mouse Mammary Tumors in another window
Includes: Supplementary data
Journal Articles

Tracking Evolution of BRCA1-Associated Breast Cancer

Jos Jonkers
Journal: Cancer Discovery
Cancer Discov (2012) 2 (6): 486–488.
https://doi.org/10.1158/2159-8290.CD-12-0186
Published: 07 June 2012
View article titled, Tracking Evolution of BRCA1-Associated Breast Cancer
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