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John M. Asara
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Journal Articles

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

Open Access
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley
Journal: Cancer Discovery
Cancer Discov (2023) 13 (4): 1002–1025.
https://doi.org/10.1158/2159-8290.CD-22-0805
Published: 03 April 2023
View articletitled, LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma
Open the PDF for LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

Free
Jinfang Zhang, Yu-Ru Lee, Fabin Dang, Wenjian Gan, Archita Venugopal Menon, Jesse M. Katon, Chih-Hung Hsu, John M. Asara, Priyanka Tibarewal, Nicholas R. Leslie, Yang Shi, Pier Paolo Pandolfi, Wenyi Wei
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (9): 1306–1323.
https://doi.org/10.1158/2159-8290.CD-18-0083
Published: 03 September 2019
View articletitled, PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage
Open the PDF for PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage in another window
Includes: Supplementary data
Journal Articles

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

Free
Riadh Lobbardi, Jordan Pinder, Barbara Martinez-Pastor, Marina Theodorou, Jessica S. Blackburn, Brian J. Abraham, Yuka Namiki, Marc Mansour, Nouran S. Abdelfattah, Aleksey Molodtsov, Gabriela Alexe, Debra Toiber, Manon de Waard, Esha Jain, Myriam Boukhali, Mattia Lion, Deepak Bhere, Khalid Shah, Alejandro Gutierrez, Kimberly Stegmaier, Lewis B. Silverman, Ruslan I. Sadreyev, John M. Asara, Marjorie A. Oettinger, Wilhelm Haas, A. Thomas Look, Richard A. Young, Raul Mostoslavsky, Graham Dellaire, David M. Langenau
Journal: Cancer Discovery
Cancer Discov (2017) 7 (11): 1336–1353.
https://doi.org/10.1158/2159-8290.CD-17-0267
Published: 01 November 2017
View articletitled, TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia
Open the PDF for TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity

Free
Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P. Gehring, Katja Helenius, Brian M. Olson, Athalia R. Pyzer, Lily C. Wang, Olivier Elemento, Jesse Novak, Thomas B. Thornley, John M. Asara, Laleh Montaser, Joshua J. Timmons, Todd M. Morgan, Yugang Wang, Elena Levantini, John G. Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Jeffrey M. Karp, Sabina Signoretti, Steven P. Balk, Lewis C. Cantley
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (7): 750–765.
https://doi.org/10.1158/2159-8290.CD-16-0778
Published: 05 July 2017
View articletitled, Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity
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Includes: Supplementary data
Journal Articles

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

Free
Deepti Mathur, Elias Stratikopoulos, Sait Ozturk, Nicole Steinbach, Sarah Pegno, Sarah Schoenfeld, Raymund Yong, Vundavalli V. Murty, John M. Asara, Lewis C. Cantley, Ramon Parsons
Journal: Cancer Discovery
Cancer Discov (2017) 7 (4): 380–390.
https://doi.org/10.1158/2159-8290.CD-16-0612
Published: 02 April 2017
View articletitled, PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
Open the PDF for PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition in another window
Includes: Supplementary data
Journal Articles

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Free
Kristin K. Brown, Jessica B. Spinelli, John M. Asara, Alex Toker
Journal: Cancer Discovery
Cancer Discov (2017) 7 (4): 391–399.
https://doi.org/10.1158/2159-8290.CD-16-0611
Published: 02 April 2017
View articletitled, Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Open the PDF for Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Free
Anguraj Sadanandam, Stephan Wullschleger, Costas A. Lyssiotis, Carsten Grötzinger, Stefano Barbi, Samantha Bersani, Jan Körner, Ismael Wafy, Andrea Mafficini, Rita T. Lawlor, Michele Simbolo, John M. Asara, Hendrik Bläker, Lewis C. Cantley, Bertram Wiedenmann, Aldo Scarpa, Douglas Hanahan
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (12): 1296–1313.
https://doi.org/10.1158/2159-8290.CD-15-0068
Published: 03 December 2015
View articletitled, A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics
Open the PDF for A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics in another window
Includes: Supplementary data
Journal Articles

Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition

Free
Enrique González-Billalabeitia, Nina Seitzer, Su Jung Song, Min Sup Song, Akash Patnaik, Xue-Song Liu, Mirjam T. Epping, Antonella Papa, Robin M. Hobbs, Ming Chen, Andrea Lunardi, Christopher Ng, Kaitlyn A. Webster, Sabina Signoretti, Massimo Loda, John M. Asara, Caterina Nardella, John G. Clohessy, Lewis C. Cantley, Pier Paolo Pandolfi
Journal: Cancer Discovery
Cancer Discov (2014) 4 (8): 896–904.
https://doi.org/10.1158/2159-8290.CD-13-0230
Published: 03 August 2014
View articletitled, Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition
Open the PDF for Vulnerabilities of PTEN–TP53-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition in another window
Includes: Supplementary data
Journal Articles

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

Free
Yan Liu, Kevin Marks, Glenn S. Cowley, Julian Carretero, Qingsong Liu, Thomas J.F. Nieland, Chunxiao Xu, Travis J. Cohoon, Peng Gao, Yong Zhang, Zhao Chen, Abigail B. Altabef, Jeremy H. Tchaicha, Xiaoxu Wang, Sung Choe, Edward M. Driggers, Jianming Zhang, Sean T. Bailey, Norman E. Sharpless, D. Neil Hayes, Nirali M. Patel, Pasi A. Janne, Nabeel Bardeesy, Jeffrey A. Engelman, Brendan D. Manning, Reuben J. Shaw, John M. Asara, Ralph Scully, Alec Kimmelman, Lauren A. Byers, Don L. Gibbons, Ignacio I. Wistuba, John V. Heymach, David J. Kwiatkowski, William Y. Kim, Andrew L. Kung, Nathanael S. Gray, David E. Root, Lewis C. Cantley, Kwok-Kin Wong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2013) 3 (8): 870–879.
https://doi.org/10.1158/2159-8290.CD-13-0015
Published: 07 August 2013
View articletitled, Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
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Includes: Supplementary data
Journal Articles

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Free
Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas A. Lyssiotis, Caterina Nardella, Pier Paolo Pandolfi, José Baselga, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf
Journal: Cancer Discovery
Cancer Discov (2012) 2 (11): 1048–1063.
https://doi.org/10.1158/2159-8290.CD-11-0336
Published: 11 November 2012
View articletitled, Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Open the PDF for Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer in another window
Includes: Supplementary data