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Jianhua Zhang
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Journal Articles

The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma

Dapeng Hao, Guangchun Han, Ansam Sinjab, Lorena Isabel Gomez-Bolanos, Rossana Lazcano, Alejandra Serrano, Sharia D. Hernandez, Enyu Dai, Xuanye Cao, Jian Hu, Minghao Dang, Ruiping Wang, Yanshuo Chu, Xingzhi Song, Jianhua Zhang, Edwin R. Parra, Jennifer A. Wargo, Stephen G. Swisher, Tina Cascone, Boris Sepesi, Andrew P. Futreal, Mingyao Li, Steven M. Dubinett, Junya Fujimoto, Luisa M. Solis Soto, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum Spira, Shabnam Shalapour, Humam Kadara, Linghua Wang
Journal: Cancer Discovery
Cancer Discov (2022) 12 (11): 2626–2645.
https://doi.org/10.1158/2159-8290.CD-21-1658
Published: 02 November 2022
View articletitled, The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma
Open the PDF for The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma

Xiaofei Song, Shiun Chang, Lucia Seminario-Vidal, Alvaro de Mingo Pulido, Leticia Tordesillas, Xingzhi Song, Rhianna A. Reed, Andrea Harkins, Shannen Whiddon, Jonathan V. Nguyen, Carlos Moran Segura, Chaomei Zhang, Sean Yoder, Zena Sayegh, Yun Zhao, Jane L. Messina, Carly M. Harro, Xiaohui Zhang, José R. Conejo-Garcia, Anders Berglund, Lubomir Sokol, Jianhua Zhang, Paulo C. Rodriguez, James J. Mulé, Andrew P. Futreal, Kenneth Y. Tsai, Pei-Ling Chen
Journal: Cancer Discovery
Cancer Discov (2022) 12 (5): 1294–1313.
https://doi.org/10.1158/2159-8290.CD-21-1207
Published: 02 May 2022
View articletitled, Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma
Open the PDF for Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma in another window
Includes: Supplementary data
Journal Articles

Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer

Pingping Hou, Avnish Kapoor, Qiang Zhang, Jiexi Li, Chang-Jiun Wu, Jun Li, Zhengdao Lan, Ming Tang, Xingdi Ma, Jeffrey J. Ackroyd, Raghu Kalluri, Jianhua Zhang, Shan Jiang, Denise J. Spring, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Discovery
Cancer Discov (2020) 10 (7): 1058–1077.
https://doi.org/10.1158/2159-8290.CD-19-0597
Published: 01 July 2020
View articletitled, Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer
Open the PDF for Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

Prasenjit Dey, Jun Li, Jianhua Zhang, Surendra Chaurasiya, Anders Strom, Huamin Wang, Wen-Ting Liao, Frederick Cavallaro, Parker Denz, Vincent Bernard, Er-Yen Yen, Giannicola Genovese, Pat Gulhati, Jielin Liu, Deepavali Chakravarti, Pingna Deng, Tingxin Zhang, Federica Carbone, Qing Chang, Haoqiang Ying, Xiaoying Shang, Denise J. Spring, Bidyut Ghosh, Nagireddy Putluri, Anirban Maitra, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Discovery
Cancer Discov (2020) 10 (4): 608–625.
https://doi.org/10.1158/2159-8290.CD-19-0297
Published: 01 April 2020
View articletitled, Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment
Open the PDF for Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Shelly Kalaora, Yochai Wolf, Tali Feferman, Eilon Barnea, Erez Greenstein, Dan Reshef, Itay Tirosh, Alexandre Reuben, Sushant Patkar, Ronen Levy, Juliane Quinkhardt, Tana Omokoko, Nouar Qutob, Ofra Golani, Jianhua Zhang, Xizeng Mao, Xingzhi Song, Chantale Bernatchez, Cara Haymaker, Marie-Andrée Forget, Caitlin Creasy, Polina Greenberg, Brett W. Carter, Zachary A. Cooper, Steven A. Rosenberg, Michal Lotem, Ugur Sahin, Guy Shakhar, Eytan Ruppin, Jennifer A. Wargo, Nir Friedman, Arie Admon, Yardena Samuels
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (11): 1366–1375.
https://doi.org/10.1158/2159-8290.CD-17-1418
Published: 01 November 2018
View articletitled, Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma
Open the PDF for Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma in another window
Includes: Multimedia, Supplementary data
Journal Articles

A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling

Gabriele Romano, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh, Dzifa Y. Duose, Fernando C.L. Carapeto, Jun Li, Jessica L.F. Teh, Andrew E. Aplin, Merry Chen, Jianhua Zhang, Alexander J. Lazar, Michael A. Davies, P. Andrew Futreal, Rodabe N. Amaria, David Y. Zhang, Jennifer A. Wargo, Lawrence N. Kwong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (5): 556–567.
https://doi.org/10.1158/2159-8290.CD-17-0745
Published: 30 April 2018
View articletitled, A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling
Open the PDF for A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling in another window
Includes: Supplementary data
Journal Articles

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

Alexandre Reuben, Rachel Gittelman, Jianjun Gao, Jiexin Zhang, Erik C. Yusko, Chang-Jiun Wu, Ryan Emerson, Jianhua Zhang, Christopher Tipton, Jun Li, Kelly Quek, Vancheswaran Gopalakrishnan, Runzhe Chen, Luis M. Vence, Tina Cascone, Marissa Vignali, Junya Fujimoto, Jaime Rodriguez-Canales, Edwin R. Parra, Latasha D. Little, Curtis Gumbs, Marie-Andrée Forget, Lorenzo Federico, Cara Haymaker, Carmen Behrens, Sharon Benzeno, Chantale Bernatchez, Boris Sepesi, Don L. Gibbons, Jennifer A. Wargo, William N. William, Jr, Stephen Swisher, John V. Heymach, Harlan Robins, J. Jack Lee, Padmanee Sharma, James P. Allison, P. Andrew Futreal, Ignacio I. Wistuba, Jianjun Zhang
Journal: Cancer Discovery
Cancer Discov (2017) 7 (10): 1088–1097.
https://doi.org/10.1158/2159-8290.CD-17-0256
Published: 02 October 2017
View articletitled, TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence
Open the PDF for TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence in another window
Includes: Supplementary data
Journal Articles

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Guocan Wang, Xin Lu, Prasenjit Dey, Pingna Deng, Chia Chin Wu, Shan Jiang, Zhuangna Fang, Kun Zhao, Ramakrishna Konaparthi, Sujun Hua, Jianhua Zhang, Elsa M. Li-Ning-Tapia, Avnish Kapoor, Chang-Jiun Wu, Neelay Bhaskar Patel, Zhenglin Guo, Vandhana Ramamoorthy, Trang N. Tieu, Tim Heffernan, Di Zhao, Xiaoying Shang, Sunada Khadka, Pingping Hou, Baoli Hu, Eun-Jung Jin, Wantong Yao, Xiaolu Pan, Zhihu Ding, Yanxia Shi, Liren Li, Qing Chang, Patricia Troncoso, Christopher J. Logothetis, Mark J. McArthur, Lynda Chin, Y. Alan Wang, Ronald A. DePinho
Journal: Cancer Discovery
Cancer Discov (2016) 6 (1): 80–95.
https://doi.org/10.1158/2159-8290.CD-15-0224
Published: 07 January 2016
View articletitled, Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
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Includes: Supplementary data
Journal Articles

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

Ferdinandos Skoulidis, Lauren A. Byers, Lixia Diao, Vassiliki A. Papadimitrakopoulou, Pan Tong, Julie Izzo, Carmen Behrens, Humam Kadara, Edwin R. Parra, Jaime Rodriguez Canales, Jianjun Zhang, Uma Giri, Jayanthi Gudikote, Maria A. Cortez, Chao Yang, Youhong Fan, Michael Peyton, Luc Girard, Kevin R. Coombes, Carlo Toniatti, Timothy P. Heffernan, Murim Choi, Garrett M. Frampton, Vincent Miller, John N. Weinstein, Roy S. Herbst, Kwok-Kin Wong, Jianhua Zhang, Padmanee Sharma, Gordon B. Mills, Waun K. Hong, John D. Minna, James P. Allison, Andrew Futreal, Jing Wang, Ignacio I. Wistuba, John V. Heymach
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (8): 860–877.
https://doi.org/10.1158/2159-8290.CD-14-1236
Published: 03 August 2015
View articletitled, Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
Open the PDF for Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities in another window
Includes: Supplementary data
Journal Articles

microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma

Giannicola Genovese, Ayla Ergun, Sachet A. Shukla, Benito Campos, Jason Hanna, Papia Ghosh, Steven N. Quayle, Kunal Rai, Simona Colla, Haoqiang Ying, Chang-Jiun Wu, Sharmistha Sarkar, Yonghong Xiao, Jianhua Zhang, Hailei Zhang, Lawrence Kwong, Katherine Dunn, Wolf Ruprecht Wiedemeyer, Cameron Brennan, Hongwu Zheng, David L. Rimm, James J. Collins, Lynda Chin
Journal: Cancer Discovery
Cancer Discov (2012) 2 (8): 736–749.
https://doi.org/10.1158/2159-8290.CD-12-0111
Published: 09 August 2012
View articletitled, microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma
Open the PDF for microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma in another window
Includes: Supplementary data