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Jeremy N. Rich
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Journal Articles

Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma

Zengpanpan Ye, Xiaolin Ai, Kailin Yang, Zhengnan Yang, Fan Fei, Xiaoling Liao, Zhixin Qiu, Ryan C. Gimple, Huairui Yuan, Hao Huang, Yanqiu Gong, Chaoxin Xiao, Jing Yue, Liang Huang, Olivier Saulnier, Wei Wang, Peidong Zhang, Lunzhi Dai, Xin Wang, Xiuxing Wang, Young Ha Ahn, Chao You, Jianguo Xu, Xiaoxiao Wan, Michael D. Taylor, Linjie Zhao, Jeremy N. Rich, Shengtao Zhou
Journal: Cancer Discovery
Cancer Discov (2023) 13 (4): 974–1001.
https://doi.org/10.1158/2159-8290.CD-22-0455
Published: 03 April 2023
View article titled, Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma
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Includes: Supplementary data
Journal Articles

Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Zhixin Qiu, Linjie Zhao, Jia Z. Shen, Zhengyu Liang, Qiulian Wu, Kailin Yang, Lihua Min, Ryan C. Gimple, Qiyuan Yang, Shruti Bhargava, Chunyu Jin, Cheryl Kim, Denise Hinz, Deobrat Dixit, Jean A. Bernatchez, Briana C. Prager, Guoxin Zhang, Zhen Dong, Deguan Lv, Xujun Wang, Leo J.Y. Kim, Zhe Zhu, Katherine A. Jones, Ye Zheng, Xiuxing Wang, Jair L. Siqueira-Neto, Lukas Chavez, Xiang-Dong Fu, Charles Spruck, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 502–521.
https://doi.org/10.1158/2159-8290.CD-20-1848
Published: 09 February 2022
View article titled, Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells
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Includes: Supplementary data
Journal Articles

CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies

Dongrui Wang, Briana C. Prager, Ryan C. Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu, Leo J.Y. Kim, Zhixin Qiu, Peng Lin, Michael H. Lorenzini, Behnam Badie, Stephen J. Forman, Qi Xie, Christine E. Brown, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2021) 11 (5): 1192–1211.
https://doi.org/10.1158/2159-8290.CD-20-1243
Published: 01 May 2021
View article titled, CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
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Includes: Supplementary data
Journal Articles

The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Hui Xian Poh, Yang Wang, Qiulian Wu, Zhixin Qiu, Reilly L. Kidwell, Leo J.Y. Kim, Qi Xie, Kristoffer Vitting-Seerup, Shruti Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, Petra Hamerlik, Samie R. Jaffrey, Jing Crystal Zhao, Xiuxing Wang, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2021) 11 (2): 480–499.
https://doi.org/10.1158/2159-8290.CD-20-0331
Published: 02 February 2021
View article titled, The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells
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Includes: Supplementary data
Journal Articles

The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

Briana C. Prager, Harish N. Vasudevan, Deobrat Dixit, Jean A. Bernatchez, Qiulian Wu, Lisa C. Wallace, Shruti Bhargava, Derrick Lee, Bradley H. King, Andrew R. Morton, Ryan C. Gimple, Melike Pekmezci, Zhe Zhu, Jair L. Siqueira-Neto, Xiuxing Wang, Qi Xie, Clark Chen, Gene H. Barnett, Michael A. Vogelbaum, Stephen C. Mack, Lukas Chavez, Arie Perry, David R. Raleigh, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2020) 10 (11): 1722–1741.
https://doi.org/10.1158/2159-8290.CD-20-0160
Published: 02 November 2020
View article titled, The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies
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Includes: Supplementary data
Journal Articles

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing

Jun-Bao Fan, Sayuri Miyauchi, Hui-Zhong Xu, Dan Liu, Leo J.Y. Kim, Christoph Burkart, Hua Cheng, Kei-ichiro Arimoto, Ming Yan, Yu Zhou, Balázs Győrffy, Klaus-Peter Knobeloch, Jeremy N. Rich, Hu Cang, Xiang-Dong Fu, Dong-Er Zhang
Journal: Cancer Discovery
Cancer Discov (2020) 10 (3): 382–393.
https://doi.org/10.1158/2159-8290.CD-19-0608
Published: 03 March 2020
View article titled, Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing
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Includes: Supplementary data
Journal Articles

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2019) 9 (11): 1556–1573.
https://doi.org/10.1158/2159-8290.CD-19-0215
Published: 01 November 2019
View article titled, Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
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Includes: Supplementary data
Journal Articles

Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling

Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, Tengqian Sun, Anthony D. Gromovsky, Qiulian Wu, Megan Wolf, Deguan Lv, Shruti Bhargava, Li Jiang, Briana C. Prager, Xiuxing Wang, Qing Ye, Zhe Zhu, Guoxin Zhang, Zhen Dong, Linjie Zhao, Derrick Lee, Junfeng Bi, Andrew E. Sloan, Paul S. Mischel, J. Mark Brown, Hu Cang, Tao Huan, Stephen C. Mack, Qi Xie, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2019) 9 (9): 1248–1267.
https://doi.org/10.1158/2159-8290.CD-19-0061
Published: 03 September 2019
View article titled, Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling
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Includes: Supplementary data
Journal Articles

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells

Kristina M. Godek, Monica Venere, Quilian Wu, Kevin D. Mills, William F. Hickey, Jeremy N. Rich, Duane A. Compton
Journal: Cancer Discovery
Cancer Discov (2016) 6 (5): 532–545.
https://doi.org/10.1158/2159-8290.CD-15-1154
Published: 01 May 2016
View article titled, Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells
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Includes: Supplementary data
Journal Articles

“PEAR-ing” Genomic and Epigenomic Analyses for Cancer Gene Discovery

Stephen C. Mack, Jeremy N. Rich, Peter C. Scacheri
Journal: Cancer Discovery
Cancer Discov (2015) 5 (10): 1018–1020.
https://doi.org/10.1158/2159-8290.CD-15-0985
Published: 30 September 2015
View article titled, “PEAR-ing” Genomic and Epigenomic Analyses for Cancer Gene Discovery
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Journal Articles

Mitotic Control of Cancer Stem Cells

Monica Venere, Tyler E. Miller, Jeremy N. Rich
Journal: Cancer Discovery
Cancer Discov (2013) 3 (2): 141–144.
https://doi.org/10.1158/2159-8290.CD-12-0588
Published: 10 February 2013
View article titled, Mitotic Control of Cancer Stem Cells
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