1-17 of 17
Jennifer A. Wargo
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma

Dapeng Hao, Guangchun Han, Ansam Sinjab, Lorena Isabel Gomez-Bolanos, Rossana Lazcano, Alejandra Serrano, Sharia D. Hernandez, Enyu Dai, Xuanye Cao, Jian Hu, Minghao Dang, Ruiping Wang, Yanshuo Chu, Xingzhi Song, Jianhua Zhang, Edwin R. Parra, Jennifer A. Wargo, Stephen G. Swisher, Tina Cascone, Boris Sepesi, Andrew P. Futreal, Mingyao Li, Steven M. Dubinett, Junya Fujimoto, Luisa M. Solis Soto, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum Spira, Shabnam Shalapour, Humam Kadara, Linghua Wang
Journal: Cancer Discovery
Cancer Discov (2022) 12 (11): 2626–2645.
https://doi.org/10.1158/2159-8290.CD-21-1658
Published: 02 November 2022
View article titled, The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma
Open the PDF for The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

Grant M. Fischer, Ali Jalali, David A. Kircher, Won-Chul Lee, Jennifer L. McQuade, Lauren E. Haydu, Aron Y. Joon, Alexandre Reuben, Mariana P. de Macedo, Fernando C. L. Carapeto, Chendong Yang, Anuj Srivastava, Chandrashekar R. Ambati, Arun Sreekumar, Courtney W. Hudgens, Barbara Knighton, Wanleng Deng, Sherise D. Ferguson, Hussein A. Tawbi, Isabella C. Glitza, Jeffrey E. Gershenwald, Y. N. Vashisht Gopal, Patrick Hwu, Jason T. Huse, Jennifer A. Wargo, P. Andrew Futreal, Nagireddy Putluri, Alexander J. Lazar, Ralph J. DeBerardinis, Joseph R. Marszalek, Jianjun Zhang, Sheri L. Holmen, Michael T. Tetzlaff, Michael A. Davies
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (5): 628–645.
https://doi.org/10.1158/2159-8290.CD-18-1489
Published: 01 May 2019
View article titled, Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases
Open the PDF for Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases in another window
Includes: Supplementary data
Journal Articles

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

Amanpreet Kaur, Brett L. Ecker, Stephen M. Douglass, Curtis H. Kugel, III, Marie R. Webster, Filipe V. Almeida, Rajasekharan Somasundaram, James Hayden, Ehsan Ban, Hossein Ahmadzadeh, Janusz Franco-Barraza, Neelima Shah, Ian A. Mellis, Frederick Keeney, Andrew Kossenkov, Hsin-Yao Tang, Xiangfan Yin, Qin Liu, Xiaowei Xu, Mitchell Fane, Patricia Brafford, Meenhard Herlyn, David W. Speicher, Jennifer A. Wargo, Michael T. Tetzlaff, Lauren E. Haydu, Arjun Raj, Vivek Shenoy, Edna Cukierman, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2019) 9 (1): 64–81.
https://doi.org/10.1158/2159-8290.CD-18-0193
Published: 09 January 2019
View article titled, Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Open the PDF for Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility in another window
Includes: Multimedia, Supplementary data
Journal Articles

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Shelly Kalaora, Yochai Wolf, Tali Feferman, Eilon Barnea, Erez Greenstein, Dan Reshef, Itay Tirosh, Alexandre Reuben, Sushant Patkar, Ronen Levy, Juliane Quinkhardt, Tana Omokoko, Nouar Qutob, Ofra Golani, Jianhua Zhang, Xizeng Mao, Xingzhi Song, Chantale Bernatchez, Cara Haymaker, Marie-Andrée Forget, Caitlin Creasy, Polina Greenberg, Brett W. Carter, Zachary A. Cooper, Steven A. Rosenberg, Michal Lotem, Ugur Sahin, Guy Shakhar, Eytan Ruppin, Jennifer A. Wargo, Nir Friedman, Arie Admon, Yardena Samuels
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (11): 1366–1375.
https://doi.org/10.1158/2159-8290.CD-17-1418
Published: 01 November 2018
View article titled, Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma
Open the PDF for Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma in another window
Includes: Multimedia, Supplementary data
Journal Articles

A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling

Gabriele Romano, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh, Dzifa Y. Duose, Fernando C.L. Carapeto, Jun Li, Jessica L.F. Teh, Andrew E. Aplin, Merry Chen, Jianhua Zhang, Alexander J. Lazar, Michael A. Davies, P. Andrew Futreal, Rodabe N. Amaria, David Y. Zhang, Jennifer A. Wargo, Lawrence N. Kwong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (5): 556–567.
https://doi.org/10.1158/2159-8290.CD-17-0745
Published: 30 April 2018
View article titled, A Preexisting Rare <em>PIK3CA</em><sup>E545K</sup> Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in <em>NRAS</em> Melanoma and Is Dependent on S6K1 Signaling
Open the PDF for A Preexisting Rare <em>PIK3CA</em><sup>E545K</sup> Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in <em>NRAS</em> Melanoma and Is Dependent on S6K1 Signaling in another window
Includes: Supplementary data
Journal Articles

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

Alexandre Reuben, Rachel Gittelman, Jianjun Gao, Jiexin Zhang, Erik C. Yusko, Chang-Jiun Wu, Ryan Emerson, Jianhua Zhang, Christopher Tipton, Jun Li, Kelly Quek, Vancheswaran Gopalakrishnan, Runzhe Chen, Luis M. Vence, Tina Cascone, Marissa Vignali, Junya Fujimoto, Jaime Rodriguez-Canales, Edwin R. Parra, Latasha D. Little, Curtis Gumbs, Marie-Andrée Forget, Lorenzo Federico, Cara Haymaker, Carmen Behrens, Sharon Benzeno, Chantale Bernatchez, Boris Sepesi, Don L. Gibbons, Jennifer A. Wargo, William N. William, Jr, Stephen Swisher, John V. Heymach, Harlan Robins, J. Jack Lee, Padmanee Sharma, James P. Allison, P. Andrew Futreal, Ignacio I. Wistuba, Jianjun Zhang
Journal: Cancer Discovery
Cancer Discov (2017) 7 (10): 1088–1097.
https://doi.org/10.1158/2159-8290.CD-17-0256
Published: 02 October 2017
View article titled, TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence
Open the PDF for TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence in another window
Includes: Supplementary data
Journal Articles

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

Banu Eskiocak, Elizabeth A. McMillan, Saurabh Mendiratta, Rahul K. Kollipara, Hailei Zhang, Caroline G. Humphries, Changguang Wang, Jose Garcia-Rodriguez, Ming Ding, Aubhishek Zaman, Tracy I. Rosales, Ugur Eskiocak, Michael P. Smith, Jessica Sudderth, Kakajan Komurov, Ralph J. Deberardinis, Claudia Wellbrock, Michael A. Davies, Jennifer A. Wargo, Yonghao Yu, Jef K. De Brabander, Noelle S. Williams, Lynda Chin, Helen Rizos, Georgina V. Long, Ralf Kittler, Michael A. White
Journal: Cancer Discovery
Cancer Discov (2017) 7 (8): 832–851.
https://doi.org/10.1158/2159-8290.CD-16-0955
Published: 01 August 2017
View article titled, Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
Open the PDF for Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma in another window
Includes: Supplementary data
Journal Articles

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

Pei-Ling Chen, Whijae Roh, Alexandre Reuben, Zachary A. Cooper, Christine N. Spencer, Peter A. Prieto, John P. Miller, Roland L. Bassett, Vancheswaran Gopalakrishnan, Khalida Wani, Mariana Petaccia De Macedo, Jacob L. Austin-Breneman, Hong Jiang, Qing Chang, Sangeetha M. Reddy, Wei-Shen Chen, Michael T. Tetzlaff, Russell J. Broaddus, Michael A. Davies, Jeffrey E. Gershenwald, Lauren Haydu, Alexander J. Lazar, Sapna P. Patel, Patrick Hwu, Wen-Jen Hwu, Adi Diab, Isabella C. Glitza, Scott E. Woodman, Luis M. Vence, Ignacio I. Wistuba, Rodabe N. Amaria, Lawrence N. Kwong, Victor Prieto, R. Eric Davis, Wencai Ma, Willem W. Overwijk, Arlene H. Sharpe, Jianhua Hu, P. Andrew Futreal, Jorge Blando, Padmanee Sharma, James P. Allison, Lynda Chin, Jennifer A. Wargo
Journal: Cancer Discovery
Cancer Discov (2016) 6 (8): 827–837.
https://doi.org/10.1158/2159-8290.CD-15-1545
Published: 01 August 2016
View article titled, Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade
Open the PDF for Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Weiyi Peng, Jie Qing Chen, Chengwen Liu, Shruti Malu, Caitlin Creasy, Michael T. Tetzlaff, Chunyu Xu, Jodi A. McKenzie, Chunlei Zhang, Xiaoxuan Liang, Leila J. Williams, Wanleng Deng, Guo Chen, Rina Mbofung, Alexander J. Lazar, Carlos A. Torres-Cabala, Zachary A. Cooper, Pei-Ling Chen, Trang N. Tieu, Stefani Spranger, Xiaoxing Yu, Chantale Bernatchez, Marie-Andree Forget, Cara Haymaker, Rodabe Amaria, Jennifer L. McQuade, Isabella C. Glitza, Tina Cascone, Haiyan S. Li, Lawrence N. Kwong, Timothy P. Heffernan, Jianhua Hu, Roland L. Bassett, Jr, Marcus W. Bosenberg, Scott E. Woodman, Willem W. Overwijk, Gregory Lizée, Jason Roszik, Thomas F. Gajewski, Jennifer A. Wargo, Jeffrey E. Gershenwald, Laszlo Radvanyi, Michael A. Davies, Patrick Hwu
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 202–216.
https://doi.org/10.1158/2159-8290.CD-15-0283
Published: 04 February 2016
View article titled, Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy
Open the PDF for Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy in another window
Includes: Supplementary data
Journal Articles

EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma

Benchun Miao, Zhenyu Ji, Li Tan, Michael Taylor, Jianming Zhang, Hwan Geun Choi, Dennie T. Frederick, Raj Kumar, Jennifer A. Wargo, Keith T. Flaherty, Nathanael S. Gray, Hensin Tsao
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 274–287.
https://doi.org/10.1158/2159-8290.CD-14-0295
Published: 05 March 2015
View article titled, EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma
Open the PDF for EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma in another window
Includes: Supplementary data
Journal Articles

Universes Collide: Combining Immunotherapy with Targeted Therapy for Cancer

Jennifer A. Wargo, Zachary A. Cooper, Keith T. Flaherty
Journal: Cancer Discovery
Cancer Discov (2014) 4 (12): 1377–1386.
https://doi.org/10.1158/2159-8290.CD-14-0477
Published: 03 December 2014
View article titled, Universes Collide: Combining Immunotherapy with Targeted Therapy for Cancer
Open the PDF for Universes Collide: Combining Immunotherapy with Targeted Therapy for Cancer in another window
Journal Articles

The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα

Michael P. Smith, Berta Sanchez-Laorden, Kate O'Brien, Holly Brunton, Jennifer Ferguson, Helen Young, Nathalie Dhomen, Keith T. Flaherty, Dennie T. Frederick, Zachary A. Cooper, Jennifer A. Wargo, Richard Marais, Claudia Wellbrock
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (10): 1214–1229.
https://doi.org/10.1158/2159-8290.CD-13-1007
Published: 30 September 2014
View article titled, The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα
Open the PDF for The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα in another window
Includes: Supplementary data
Journal Articles

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

David J. Konieczkowski, Cory M. Johannessen, Omar Abudayyeh, Jong Wook Kim, Zachary A. Cooper, Adriano Piris, Dennie T. Frederick, Michal Barzily-Rokni, Ravid Straussman, Rizwan Haq, David E. Fisher, Jill P. Mesirov, William C. Hahn, Keith T. Flaherty, Jennifer A. Wargo, Pablo Tamayo, Levi A. Garraway
Journal: Cancer Discovery
Cancer Discov (2014) 4 (7): 816–827.
https://doi.org/10.1158/2159-8290.CD-13-0424
Published: 06 July 2014
View article titled, A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
Open the PDF for A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors in another window
Includes: Supplementary data
Journal Articles

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Nikhil Wagle, Eliezer M. Van Allen, Daniel J. Treacy, Dennie T. Frederick, Zachary A. Cooper, Amaro Taylor-Weiner, Mara Rosenberg, Eva M. Goetz, Ryan J. Sullivan, Deborah N. Farlow, Dennis C. Friedrich, Kristin Anderka, Danielle Perrin, Cory M. Johannessen, Aaron McKenna, Kristian Cibulskis, Gregory Kryukov, Eran Hodis, Donald P. Lawrence, Sheila Fisher, Gad Getz, Stacey B. Gabriel, Scott L. Carter, Keith T. Flaherty, Jennifer A. Wargo, Levi A. Garraway
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (1): 61–68.
https://doi.org/10.1158/2159-8290.CD-13-0631
Published: 07 January 2014
View article titled, MAP Kinase Pathway Alterations in <em>BRAF</em>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
Open the PDF for MAP Kinase Pathway Alterations in <em>BRAF</em>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Michael P. O'Connell, Katie Marchbank, Marie R. Webster, Alexander A. Valiga, Amanpreet Kaur, Adina Vultur, Ling Li, Meenhard Herlyn, Jessie Villanueva, Qin Liu, Xiangfan Yin, Sandy Widura, Janelle Nelson, Nivia Ruiz, Tura C. Camilli, Fred E. Indig, Keith T. Flaherty, Jennifer A. Wargo, Dennie T. Frederick, Zachary A. Cooper, Suresh Nair, Ravi K. Amaravadi, Lynn M. Schuchter, Giorgos C. Karakousis, Wei Xu, Xiaowei Xu, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1378–1393.
https://doi.org/10.1158/2159-8290.CD-13-0005
Published: 01 December 2013
View article titled, Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
Open the PDF for Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2 in another window
Includes: Supplementary data
Journal Articles

Elucidating Distinct Roles for NF1 in Melanomagenesis

Ophélia Maertens, Bryan Johnson, Pablo Hollstein, Dennie T. Frederick, Zachary A. Cooper, Ludwine Messiaen, Roderick T. Bronson, Martin McMahon, Scott Granter, Keith Flaherty, Jennifer A. Wargo, Richard Marais, Karen Cichowski
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 338–349.
https://doi.org/10.1158/2159-8290.CD-12-0313
Published: 07 March 2013
View article titled, Elucidating Distinct Roles for <em>NF1</em> in Melanomagenesis
Open the PDF for Elucidating Distinct Roles for <em>NF1</em> in Melanomagenesis in another window
Includes: Supplementary data
Journal Articles

EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF-Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib

Ryan B. Corcoran, Hiromichi Ebi, Alexa B. Turke, Erin M. Coffee, Michiya Nishino, Alexandria P. Cogdill, Ronald D. Brown, Patricia Della Pelle, Dora Dias-Santagata, Kenneth E. Hung, Keith T. Flaherty, Adriano Piris, Jennifer A. Wargo, Jeffrey Settleman, Mari Mino-Kenudson, Jeffrey A. Engelman
Journal: Cancer Discovery
Cancer Discov (2012) 2 (3): 227–235.
https://doi.org/10.1158/2159-8290.CD-11-0341
Published: 13 March 2012
View article titled, EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of <em>BRAF</em>-Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib
Open the PDF for EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of <em>BRAF</em>-Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib in another window
Includes: Supplementary data