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Hugues de Thé
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Journal Articles

Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function

Open Access
Pierre Bercier, Qian Qian Wang, Ning Zang, Jie Zhang, Chang Yang, Yasen Maimaitiyiming, Majdouline Abou-Ghali, Caroline Berthier, Chengchen Wu, Michiko Niwa-Kawakita, Thassadite Dirami, Marie-Claude Geoffroy, Omar Ferhi, Samuel Quentin, Shirine Benhenda, Yasumitsu Ogra, Zoher Gueroui, Chun Zhou, Hua Naranmandura, Hugues de Thé, Valérie Lallemand-Breitenbach
Journal: Cancer Discovery
Cancer Discov (2023) 13 (12): 2548–2565.
https://doi.org/10.1158/2159-8290.CD-23-0453
Published: 12 December 2023
View articletitled, Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Open the PDF for Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function in another window
Includes: Multimedia, Supplementary data
Journal Articles

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Open Access
Hsin-Chieh Wu, Domitille Rérolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stéphanie Gachet, Jean Soulier, Sylvère Durand, Jennifer J. Trowbridge, Paule Bénit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, Hervé Dombret, Pierre Fenaux, Olivier Espeli, Guido Kroemer, Lorenzo Brunetti, Tak W. Mak, Valérie Lallemand-Breitenbach, Ali Bazarbachi, Brunangelo Falini, Keisuke Ito, Maria Paola Martelli, Hugues de Thé
Journal: Cancer Discovery
Cancer Discov (2021) 11 (12): 3198–3213.
https://doi.org/10.1158/2159-8290.CD-21-0177
Published: 01 December 2021
View articletitled, Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy
Open the PDF for Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy in another window
Includes: Supplementary data
Journal Articles

Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation

Free
Stéphanie Gachet, Tiama El-Chaar, David Avran, Eulalia Genesca, Frédéric Catez, Samuel Quentin, Marc Delord, Gabriel Thérizols, Delphine Briot, Godelieve Meunier, Lucie Hernandez, Marika Pla, Willem K. Smits, Jessica G. Buijs-Gladdines, Wouter Van Loocke, Gerben Menschaert, Isabelle André-Schmutz, Tom Taghon, Pieter Van Vlierberghe, Jules P. Meijerink, André Baruchel, Hervé Dombret, Emmanuelle Clappier, Jean-Jacques Diaz, Claude Gazin, Hugues de Thé, François Sigaux, Jean Soulier
Journal: Cancer Discovery
Cancer Discov (2018) 8 (12): 1614–1631.
https://doi.org/10.1158/2159-8290.CD-17-0831
Published: 03 December 2018
View articletitled, Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation
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Includes: Supplementary data
Journal Articles

The Drug-Induced Degradation of Oncoproteins: An Unexpected Achilles' Heel of Cancer Cells?

Free
Julien Ablain, Rihab Nasr, Ali Bazarbachi, Hugues de Thé
Journal: Cancer Discovery
Cancer Discov (2011) 1 (2): 117–127.
https://doi.org/10.1158/2159-8290.CD-11-0087
Published: 17 July 2011
View articletitled, The Drug-Induced Degradation of Oncoproteins: An Unexpected Achilles' Heel of Cancer Cells?
Open the PDF for The Drug-Induced Degradation of Oncoproteins: An Unexpected Achilles' Heel of Cancer Cells? in another window