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Guillermina Lozano
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Journal Articles

Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

Open Access
Anna M. Puzio-Kuter, Lizhong Xu, Mary Kate McBrayer, Romyr Dominique, Hongju H. Li, Bruce J. Fahr, Alyssa M. Brown, Amy E. Wiebesiek, Brandon M. Russo, Chris L. Mulligan, Hong Yang, Josh Battaglia, Kimberly A. Robell, Dafydd H. Thomas, Kuo-Sen Huang, Alexander Solovyov, Benjamin D. Greenbaum, Jonathan D. Oliner, Thomas W. Davis, Melissa L. Dumble, Melissa L. Johnson, Shunbin Xiong, Peirong Yang, Guillermina Lozano, Marc M. Fellous, Binh T. Vu, Alison M. Schram, Arnold J. Levine, Masha V. Poyurovsky
Journal: Cancer Discovery
Cancer Discov OF1–OF21.
https://doi.org/10.1158/2159-8290.CD-24-1421
Published: 05 May 2025
View articletitled, Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
Open the PDF for Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator in another window
Includes: Supplementary data
Journal Articles

Mutant p53 Gain of Function: Why Many See It, Why Some Do not

Available to Purchase
Guillermina Lozano, Carol Prives, Kanaga Sabapathy
Journal: Cancer Discovery
Cancer Discov OF1–OF6.
https://doi.org/10.1158/2159-8290.CD-24-1638
Published: 27 April 2025
View articletitled, Mutant p53 Gain of Function: Why Many See It, Why Some Do not
Open the PDF for Mutant p53 Gain of Function: Why Many See It, Why Some Do not in another window
Journal Articles

Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program

Available to Purchase
Jovanka Gencel-Augusto, Xiaoping Su, Yuan Qi, Elizabeth M. Whitley, Vinod Pant, Shunbin Xiong, Vrutant Shah, Jerome Lin, Encarnacion Perez, Marta L. Fiorotto, Iqbal Mahmud, Abhinav K. Jain, Philip L. Lorenzi, Nicholas E. Navin, Ellen R. Richie, Guillermina Lozano
Journal: Cancer Discovery
Cancer Discov (2023) 13 (5): 1230–1249.
https://doi.org/10.1158/2159-8290.CD-22-0872
Published: 04 May 2023
View articletitled, Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Open the PDF for Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program in another window
Includes: Supplementary data
Journal Articles

Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis

Available to Purchase
Michael P. Kim, Xinqun Li, Jenying Deng, Yun Zhang, Bingbing Dai, Kendra L. Allton, Tara G. Hughes, Christian Siangco, Jithesh J. Augustine, Ya'an Kang, Joy M. McDaniel, Shunbin Xiong, Eugene J. Koay, Florencia McAllister, Christopher A. Bristow, Timothy P. Heffernan, Anirban Maitra, Bin Liu, Michelle C. Barton, Amanda R. Wasylishen, Jason B. Fleming, Guillermina Lozano
Journal: Cancer Discovery
Cancer Discov (2021) 11 (8): 2094–2111.
https://doi.org/10.1158/2159-8290.CD-20-1228
Published: 01 August 2021
View articletitled, Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis
Open the PDF for Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

DEAR1 Is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGF-β–Driven Epithelial–Mesenchymal Transition

Free
Nanyue Chen, Seetharaman Balasenthil, Jacquelyn Reuther, Aileen Frayna, Ying Wang, Dawn S. Chandler, Lynne V. Abruzzo, Asif Rashid, Jaime Rodriguez, Guillermina Lozano, Yu Cao, Erica Lokken, Jinyun Chen, Marsha L. Frazier, Aysegul A. Sahin, Ignacio I. Wistuba, Subrata Sen, Steven T. Lott, Ann McNeill Killary
Journal: Cancer Discovery
Cancer Discov (2013) 3 (10): 1172–1189.
https://doi.org/10.1158/2159-8290.CD-12-0499
Published: 10 October 2013
View articletitled, DEAR1 Is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGF-β–Driven Epithelial–Mesenchymal Transition
Open the PDF for DEAR1 Is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGF-β–Driven Epithelial–Mesenchymal Transition in another window
Includes: Multimedia, Supplementary data