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Guido Kroemer
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Journal Articles

Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency

Open Access
Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil, Janesa Srikanthan, Rim ABDALLAH, Valentina Petrocelli, Jessica Rengassamy, Alexia Alfaro, Mathilde Bied, Marine Fidelle, Gladys Ferrere, Romain Daillere, Ahmadreza Arbab, Roula Amine-Hneineh, Arnaud Pages, Peggy Dartigues, Pierre Ly, Sylvain Simon, Sylvere Durand, Adrian Gottschlich, Florent Ginhoux, Camille Bleriot, Peng Liu, Liwei Zhao, Laura Creusot, Nathalie Rolhion, Lisa Derosa, Guido Kroemer, Laurie Menger, Sebastian Kobold, Cristina Castilla-Llorente, Harry Sokol, Stefano Casola, Edoardo Pasolli, Laurence Zitvogel, Camille Bigenwald
Journal: Cancer Discovery
Cancer Discov (2025)
https://doi.org/10.1158/2159-8290.CD-24-1230
Published: 11 June 2025
View article titled, Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency
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Includes: Supplementary data
Journal Articles

Cancer and the Metaorganism

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Laurence Zitvogel, Guido Kroemer
Journal: Cancer Discovery
Cancer Discov (2024) 14 (4): 658–662.
https://doi.org/10.1158/2159-8290.CD-23-1484
Published: 04 April 2024
View article titled, Cancer and the Metaorganism
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Journal Articles

BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

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Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H.K. Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Journal: Cancer Discovery
Cancer Discov (2023) 13 (11): 2448–2469.
https://doi.org/10.1158/2159-8290.CD-22-1338
Published: 01 November 2023
View article titled, BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance
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Includes: Supplementary data
Journal Articles

The DNA Damage Response and Inflammation in Cancer

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Vanessa Klapp, Beatriz Álvarez-Abril, Giuseppe Leuzzi, Guido Kroemer, Alberto Ciccia, Lorenzo Galluzzi
Journal: Cancer Discovery
Cancer Discov (2023) 13 (7): 1521–1545.
https://doi.org/10.1158/2159-8290.CD-22-1220
Published: 07 July 2023
View article titled, The DNA Damage Response and Inflammation in Cancer
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Includes: Supplementary data
Journal Articles

Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer

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Léa Montégut, Rafael de Cabo, Laurence Zitvogel, Guido Kroemer
Journal: Cancer Discovery
Cancer Discov (2022) 12 (10): 2258–2279.
https://doi.org/10.1158/2159-8290.CD-22-0504
Published: 05 October 2022
View article titled, Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer
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Includes: Supplementary data
Journal Articles

Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer

Free
Anne-Gaëlle Goubet, Leonardo Lordello, Carolina Alves Costa Silva, Isabelle Peguillet, Marianne Gazzano, Maxime Descartes Mbogning-Fonkou, Cassandra Thelemaque, Cédric Lebacle, Constance Thibault, François Audenet, Géraldine Pignot, Gwenaelle Gravis, Carole Helissey, Luca Campedel, Morgan Roupret, Evanguelos Xylinas, Idir Ouzaid, Agathe Dubuisson, Marine Mazzenga, Caroline Flament, Pierre Ly, Virginie Marty, Nicolas Signolle, Allan Sauvat, Thomas Sbarrato, Mounia Filahi, Caroline Davin, Gabriel Haddad, Jacques Bou Khalil, Camille Bleriot, François-Xavier Danlos, Garett Dunsmore, Kevin Mulder, Aymeric Silvin, Thibault Raoult, Baptiste Archambaud, Shaima Belhechmi, Ivo Gomperts Boneca, Nadège Cayet, Maryse Moya-Nilges, Adeline Mallet, Romain Daillere, Etienne Rouleau, Camelia Radulescu, Yves Allory, Jacques Fieschi, Mathieu Rouanne, Florent Ginhoux, Gwénaël Le Teuff, Lisa Derosa, Aurélien Marabelle, Jeroen Van Dorp, Nick Van Dijk, Michiel S. Van Der Heijden, Benjamin Besse, Fabrice Andre, Miriam Merad, Guido Kroemer, Jean-Yves Scoazec, Laurence Zitvogel, Yohann Loriot
Journal: Cancer Discovery
Cancer Discov (2022) 12 (10): 2280–2307.
https://doi.org/10.1158/2159-8290.CD-22-0201
Published: 05 October 2022
View article titled, Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer
Open the PDF for Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer in another window
Includes: Supplementary data
Journal Articles

The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Open Access
Jean-Eudes Fahrner, Imran Lahmar, Anne-Gaëlle Goubet, Yacine Haddad, Agathe Carrier, Marine Mazzenga, Damien Drubay, Carolina Alves Costa Silva, Lyon COVID Study Group, Eric de Sousa, Cassandra Thelemaque, Cléa Melenotte, Agathe Dubuisson, Arthur Geraud, Gladys Ferrere, Roxanne Birebent, Camille Bigenwald, Marion Picard, Luigi Cerbone, Joana R. Lérias, Ariane Laparra, Alice Bernard-Tessier, Benoît Kloeckner, Marianne Gazzano, François-Xavier Danlos, Safae Terrisse, Eugenie Pizzato, Caroline Flament, Pierre Ly, Eric Tartour, Nadine Benhamouda, Lydia Meziani, Abdelhakim Ahmed-Belkacem, Makoto Miyara, Guy Gorochov, Fabrice Barlesi, Alexandre Trubert, Benjamin Ungar, Yeriel Estrada, Caroline Pradon, Emmanuelle Gallois, Fanny Pommeret, Emeline Colomba, Pernelle Lavaud, Marc Deloger, Nathalie Droin, Eric Deutsch, Bertrand Gachot, Jean-Philippe Spano, Mansouria Merad, Florian Scotté, Aurélien Marabelle, Frank Griscelli, Jean-Yves Blay, Jean-Charles Soria, Miriam Merad, Fabrice André, Juliette Villemonteix, Mathieu F. Chevalier, Sophie Caillat-Zucman, Florence Fenollar, Emma Guttman-Yassky, Odile Launay, Guido Kroemer, Bernard La Scola, Markus Maeurer, Lisa Derosa, Laurence Zitvogel
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 958–983.
https://doi.org/10.1158/2159-8290.CD-21-1441
Published: 01 April 2022
View article titled, The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals
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Includes: Supplementary data
Journal Articles

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

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Satoru Yonekura, Safae Terrisse, Carolina Alves Costa Silva, Antoine Lafarge, Valerio Iebba, Gladys Ferrere, Anne-Gaëlle Goubet, Jean-Eudes Fahrner, Imran Lahmar, Kousuke Ueda, Gibrail Mansouri, Eugénie Pizzato, Pierre Ly, Marine Mazzenga, Cassandra Thelemaque, Marine Fidelle, Fanny Jaulin, Jérôme Cartry, Marc Deloger, Marine Aglave, Nathalie Droin, Paule Opolon, Angélique Puget, Fanny Mann, Michel Neunlist, Anne Bessard, Laetitia Aymeric, Tamara Matysiak-Budnik, Jacques Bosq, Paul Hofman, Connie P.M. Duong, Sophie Ugolini, Valentin Quiniou, Sylvie Berrard, Bernhard Ryffel, Oliver Kepp, Guido Kroemer, Bertrand Routy, Leonardo Lordello, Mohamed-Amine Bani, Nicola Segata, Fjodor Yousef Yengej, Hans Clevers, Jean-Yves Scoazec, Edoardo Pasolli, Lisa Derosa, Laurence Zitvogel
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1128–1151.
https://doi.org/10.1158/2159-8290.CD-21-0999
Published: 01 April 2022
View article titled, Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis
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Includes: Supplementary data
Journal Articles

A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Open Access
Meriem Messaoudene, Reilly Pidgeon, Corentin Richard, Mayra Ponce, Khoudia Diop, Myriam Benlaifaoui, Alexis Nolin-Lapalme, Florent Cauchois, Julie Malo, Wiam Belkaid, Stephane Isnard, Yves Fradet, Lharbi Dridi, Dominique Velin, Paul Oster, Didier Raoult, François Ghiringhelli, Romain Boidot, Sandy Chevrier, David T. Kysela, Yves V. Brun, Emilia Liana Falcone, Geneviève Pilon, Florian Plaza Oñate, Oscar Gitton-Quent, Emmanuelle Le Chatelier, Sylvere Durand, Guido Kroemer, Arielle Elkrief, André Marette, Bastien Castagner, Bertrand Routy
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1070–1087.
https://doi.org/10.1158/2159-8290.CD-21-0808
Published: 01 April 2022
View article titled, A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota
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Includes: Supplementary data
Journal Articles

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Open Access
Hsin-Chieh Wu, Domitille Rérolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stéphanie Gachet, Jean Soulier, Sylvère Durand, Jennifer J. Trowbridge, Paule Bénit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, Hervé Dombret, Pierre Fenaux, Olivier Espeli, Guido Kroemer, Lorenzo Brunetti, Tak W. Mak, Valérie Lallemand-Breitenbach, Ali Bazarbachi, Brunangelo Falini, Keisuke Ito, Maria Paola Martelli, Hugues de Thé
Journal: Cancer Discovery
Cancer Discov (2021) 11 (12): 3198–3213.
https://doi.org/10.1158/2159-8290.CD-21-0177
Published: 01 December 2021
View article titled, Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy
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Includes: Supplementary data
Journal Articles

Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?

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Lisa Derosa, Bertrand Routy, Antoine Desilets, Romain Daillère, Safae Terrisse, Guido Kroemer, Laurence Zitvogel
Journal: Cancer Discovery
Cancer Discov (2021) 11 (10): 2396–2412.
https://doi.org/10.1158/2159-8290.CD-21-0236
Published: 01 October 2021
View article titled, Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?
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Includes: Supplementary data
Journal Articles

A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency

Free
Julie Le Naour, Peng Liu, Liwei Zhao, Sandy Adjemian, Zsofia Sztupinszki, Julien Taieb, Claire Mulot, Aymeric Silvin, Charles-Antoine Dutertre, Florent Ginhoux, Allan Sauvat, Giulia Cerrato, Francesca Castoldi, Isabelle Martins, Gautier Stoll, Juliette Paillet, Khady Mangane, Cornelia Richter, Oliver Kepp, Maria Chiara Maiuri, Federico Pietrocola, Peter Vandenabeele, Fabrice André, Suzette Delaloge, Zoltan Szallasi, Pierre Laurent-Puig, Jessica Zucman-Rossi, Laurence Zitvogel, Jonathan G. Pol, Erika Vacchelli, Guido Kroemer
Journal: Cancer Discovery
Cancer Discov (2021) 11 (2): 408–423.
https://doi.org/10.1158/2159-8290.CD-20-0465
Published: 02 February 2021
View article titled, A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency
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Includes: Supplementary data
Journal Articles

Lower Airway Dysbiosis Exacerbates Lung Cancer

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Laurence Zitvogel, Guido Kroemer
Journal: Cancer Discovery
Cancer Discov (2021) 11 (2): 224–226.
https://doi.org/10.1158/2159-8290.CD-20-1641
Published: 02 February 2021
View article titled, Lower Airway Dysbiosis Exacerbates Lung Cancer
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Journal Articles

Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers

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Xinxin Song, Zhuan Zhou, Hongchun Li, Yifan Xue, Xinghua Lu, Ivet Bahar, Oliver Kepp, Mien-Chie Hung, Guido Kroemer, Yong Wan
Journal: Cancer Discovery
Cancer Discov (2020) 10 (12): 1872–1893.
https://doi.org/10.1158/2159-8290.CD-20-0402
Published: 01 December 2020
View article titled, Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers
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Includes: Multimedia, Supplementary data