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Gordon J. Freeman
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Journal Articles

Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

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Jared H. Rowe, Ilaria Elia, Osmaan Shahid, Emily F. Gaudiano, Natalia E. Sifnugel, Sheila Johnson, Amy G. Reynolds, Megan E. Fung, Shakchhi Joshi, Martin W. LaFleur, Joon Seok Park, Kristen E. Pauken, Joshua D. Rabinowitz, Gordon J. Freeman, Marcia C. Haigis, Arlene H. Sharpe
Journal: Cancer Discovery
Cancer Discov (2023) 13 (12): 2566–2583.
https://doi.org/10.1158/2159-8290.CD-22-1301
Published: 12 December 2023
View articletitled, Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade
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Includes: Supplementary data
Journal Articles

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade

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Shengqing Stan Gu, Wubing Zhang, Xiaoqing Wang, Peng Jiang, Nicole Traugh, Ziyi Li, Clifford Meyer, Blair Stewig, Yingtian Xie, Xia Bu, Michael P. Manos, Alba Font-Tello, Evisa Gjini, Ana Lako, Klothilda Lim, Jake Conway, Alok K. Tewari, Zexian Zeng, Avinash Das Sahu, Collin Tokheim, Jason L. Weirather, Jingxin Fu, Yi Zhang, Benjamin Kroger, Jin Hua Liang, Paloma Cejas, Gordon J. Freeman, Scott Rodig, Henry W. Long, Benjamin E. Gewurz, F. Stephen Hodi, Myles Brown, X. Shirley Liu
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1524–1541.
https://doi.org/10.1158/2159-8290.CD-20-0812
Published: 01 June 2021
View articletitled, Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
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Includes: Supplementary data
Journal Articles

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade

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Cécile Gstalder, David Liu, Diana Miao, Bart Lutterbach, Alexander L. DeVine, Chenyu Lin, Megha Shettigar, Priya Pancholi, Elizabeth I. Buchbinder, Scott L. Carter, Michael P. Manos, Vanesa Rojas-Rudilla, Ryan Brennick, Evisa Gjini, Pei-Hsuan Chen, Ana Lako, Scott Rodig, Charles H. Yoon, Gordon J. Freeman, David A. Barbie, F. Stephen Hodi, Wayne Miles, Eliezer M. Van Allen, Rizwan Haq
Journal: Cancer Discovery
Cancer Discov (2020) 10 (9): 1296–1311.
https://doi.org/10.1158/2159-8290.CD-19-1416
Published: 01 September 2020
View articletitled, Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade
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Includes: Supplementary data
Journal Articles

In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

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Fei Li, Qingyuan Huang, Troy A. Luster, Hai Hu, Hua Zhang, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Wei Wang, Ting Chen, Jiehui Deng, Michela Ranieri, Zhaoyuan Fang, Val Pyon, Catríona M. Dowling, Ece Bagdatlioglu, Christina Almonte, Kristen Labbe, Heather Silver, Alexandra R. Rabin, Kandarp Jani, Aristotelis Tsirigos, Thales Papagiannakopoulos, Peter S. Hammerman, Vamsidhar Velcheti, Gordon J. Freeman, Jun Qi, George Miller, Kwok-Kin Wong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (2): 270–287.
https://doi.org/10.1158/2159-8290.CD-19-0780
Published: 05 February 2020
View articletitled, In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma
Open the PDF for In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

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Jiehui Deng, Eric S. Wang, Russell W. Jenkins, Shuai Li, Ruben Dries, Kathleen Yates, Sandeep Chhabra, Wei Huang, Hongye Liu, Amir R. Aref, Elena Ivanova, Cloud P. Paweletz, Michaela Bowden, Chensheng W. Zhou, Grit S. Herter-Sprie, Jessica A. Sorrentino, John E. Bisi, Patrick H. Lizotte, Ashley A. Merlino, Max M. Quinn, Lauren E. Bufe, Annan Yang, Yanxi Zhang, Hua Zhang, Peng Gao, Ting Chen, Megan E. Cavanaugh, Amanda J. Rode, Eric Haines, Patrick J. Roberts, Jay C. Strum, William G. Richards, Jochen H. Lorch, Sareh Parangi, Viswanath Gunda, Genevieve M. Boland, Raphael Bueno, Sangeetha Palakurthi, Gordon J. Freeman, Jerome Ritz, W. Nicholas Haining, Norman E. Sharpless, Haribabu Arthanari, Geoffrey I. Shapiro, David A. Barbie, Nathanael S. Gray, Kwok-Kin Wong
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 216–233.
https://doi.org/10.1158/2159-8290.CD-17-0915
Published: 04 February 2018
View articletitled, CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
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Includes: Supplementary data
Journal Articles

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

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Russell W. Jenkins, Amir R. Aref, Patrick H. Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W. Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A. Kaplan, Andrew Portell, Prafulla C. Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E. Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C. Thai, Marc R. Hammond, Raven Vlahos, Eric S. Wang, Hua Zhang, Shuai Li, Glenn J. Hanna, Wei Huang, Mai P. Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O. Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R. LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M. Cleary, Brian C. Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U. Barbie, Vivek Sivathanu, Joshua Wong, William G. Richards, Raphael Bueno, Charles H. Yoon, Juan Miret, Meenhard Herlyn, Levi A. Garraway, Eliezer M. Van Allen, Gordon J. Freeman, Paul T. Kirschmeier, Jochen H. Lorch, Patrick A. Ott, F. Stephen Hodi, Keith T. Flaherty, Roger D. Kamm, Genevieve M. Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 196–215.
https://doi.org/10.1158/2159-8290.CD-17-0833
Published: 04 February 2018
View articletitled, Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
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Includes: Multimedia, Supplementary data
Journal Articles

Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

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Carlos R. Gil Del Alcazar, Sung Jin Huh, Muhammad B. Ekram, Anne Trinh, Lin L. Liu, Francisco Beca, Xiaoyuan Zi, Minsuk Kwak, Helga Bergholtz, Ying Su, Lina Ding, Hege G. Russnes, Andrea L. Richardson, Kirsten Babski, Elizabeth Min Hui Kim, Charles H. McDonnell, III, Jon Wagner, Ron Rowberry, Gordon J. Freeman, Deborah Dillon, Therese Sorlie, Lisa M. Coussens, Judy E. Garber, Rong Fan, Kristie Bobolis, D. Craig Allred, Joon Jeong, So Yeon Park, Franziska Michor, Kornelia Polyak
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (10): 1098–1115.
https://doi.org/10.1158/2159-8290.CD-17-0222
Published: 02 October 2017
View articletitled, Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition
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Includes: Supplementary data
Journal Articles

The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy

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Yanping Xiao, Gordon J. Freeman
Journal: Cancer Discovery
Cancer Discov (2015) 5 (1): 16–18.
https://doi.org/10.1158/2159-8290.CD-14-1397
Published: 11 January 2015
View articletitled, The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy
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Journal Articles

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

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Esra A. Akbay, Shohei Koyama, Julian Carretero, Abigail Altabef, Jeremy H. Tchaicha, Camilla L. Christensen, Oliver R. Mikse, Andrew D. Cherniack, Ellen M. Beauchamp, Trevor J. Pugh, Matthew D. Wilkerson, Peter E. Fecci, Mohit Butaney, Jacob B. Reibel, Margaret Soucheray, Travis J. Cohoon, Pasi A. Janne, Matthew Meyerson, D. Neil Hayes, Geoffrey I. Shapiro, Takeshi Shimamura, Lynette M. Sholl, Scott J. Rodig, Gordon J. Freeman, Peter S. Hammerman, Glenn Dranoff, Kwok-Kin Wong
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2013) 3 (12): 1355–1363.
https://doi.org/10.1158/2159-8290.CD-13-0310
Published: 10 December 2013
View articletitled, Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Open the PDF for Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors in another window
Includes: Supplementary data