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Gerburg M. Wulf
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Journal Articles

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E. Martin, Bryanna L. Norden, Nicholas Chevalier, Allison M. Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S. Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P. Danysh, Laxmi Parida, Ioannis Sanidas, Yongli Ji, Kayao Lau, Gerburg M. Wulf, Aditya Bardia, Laura M. Spring, Steven J. Isakoff, Jochen K. Lennerz, Kathryn Del Vecchio, Levi Pierce, Ermira Pazolli, Gad Getz, Ryan B. Corcoran, Dejan Juric
Journal: Cancer Discovery
Cancer Discov (2024) 14 (2): 227–239.
https://doi.org/10.1158/2159-8290.CD-23-0704
Published: 08 February 2024
View article titled, Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary <em>PIK3CA</em> Mutations
Open the PDF for Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary <em>PIK3CA</em> Mutations in another window
Includes: Supplementary data
Journal Articles

The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

Hui Liu, Marcia N. Paddock, Haibin Wang, Charles J. Murphy, Renee C. Geck, Adrija J. Navarro, Gerburg M. Wulf, Olivier Elemento, Volker Haucke, Lewis C. Cantley, Alex Toker
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (8): 1226–1239.
https://doi.org/10.1158/2159-8290.CD-19-1262
Published: 03 August 2020
View article titled, The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer
Open the PDF for The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

Constantia Pantelidou, Olmo Sonzogni, Mateus De Oliveria Taveira, Anita K. Mehta, Aditi Kothari, Dan Wang, Tanvi Visal, Michelle K. Li, Jocelin Pinto, Jessica A. Castrillon, Emily M. Cheney, Peter Bouwman, Jos Jonkers, Sven Rottenberg, Jennifer L. Guerriero, Gerburg M. Wulf, Geoffrey I. Shapiro
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (6): 722–737.
https://doi.org/10.1158/2159-8290.CD-18-1218
Published: 03 June 2019
View article titled, PARP Inhibitor Efficacy Depends on CD8<sup>+</sup> T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer
Open the PDF for PARP Inhibitor Efficacy Depends on CD8<sup>+</sup> T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

Hui Liu, Charles J. Murphy, Florian A. Karreth, Kristina B. Emdal, Forest M. White, Olivier Elemento, Alex Toker, Gerburg M. Wulf, Lewis C. Cantley
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (3): 354–369.
https://doi.org/10.1158/2159-8290.CD-17-0679
Published: 01 March 2018
View article titled, Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer
Open the PDF for Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas A. Lyssiotis, Caterina Nardella, Pier Paolo Pandolfi, José Baselga, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf
Journal: Cancer Discovery
Cancer Discov (2012) 2 (11): 1048–1063.
https://doi.org/10.1158/2159-8290.CD-11-0336
Published: 11 November 2012
View article titled, Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Open the PDF for Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer in another window
Includes: Supplementary data