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Gabriela Alexe
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Journal Articles

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts

Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda S. Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Saur Conway, Delan Khalid, Jennifer A. Perry, Mark Wunderlich, Lina Benajiba, Yana Pikman, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2022) 12 (7): 1760–1781.
https://doi.org/10.1158/2159-8290.CD-21-0956
Published: 06 July 2022
View article titled, Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts
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Includes: Supplementary data
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Dombret, Claude Preudhomme, Nina Fenouille, Lina Benajiba, Hava M. Golan, Kimberly Stegmaier, Camille Lobry, Kris C. Wood, Raphael Itzykson, Alexandre Puissant
Journal: Cancer Discovery
Cancer Discov (2020) 10 (12): 1894–1911.
https://doi.org/10.1158/2159-8290.CD-19-0970
Published: 01 December 2020
View article titled, The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies
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Includes: Supplementary data
Journal Articles

Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia

Anjali Cremer, Jana M. Ellegast, Gabriela Alexe, Elizabeth S. Frank, Linda Ross, S. Haihua Chu, Yana Pikman, Amanda Robichaud, Amy Goodale, Björn Häupl, Sebastian Mohr, Arati V. Rao, Alison R. Walker, James S. Blachly, Federica Piccioni, Scott A. Armstrong, John C. Byrd, Thomas Oellerich, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2020) 10 (2): 214–231.
https://doi.org/10.1158/2159-8290.CD-19-0209
Published: 05 February 2020
View article titled, Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

Riadh Lobbardi, Jordan Pinder, Barbara Martinez-Pastor, Marina Theodorou, Jessica S. Blackburn, Brian J. Abraham, Yuka Namiki, Marc Mansour, Nouran S. Abdelfattah, Aleksey Molodtsov, Gabriela Alexe, Debra Toiber, Manon de Waard, Esha Jain, Myriam Boukhali, Mattia Lion, Deepak Bhere, Khalid Shah, Alejandro Gutierrez, Kimberly Stegmaier, Lewis B. Silverman, Ruslan I. Sadreyev, John M. Asara, Marjorie A. Oettinger, Wilhelm Haas, A. Thomas Look, Richard A. Young, Raul Mostoslavsky, Graham Dellaire, David M. Langenau
Journal: Cancer Discovery
Cancer Discov (2017) 7 (11): 1336–1353.
https://doi.org/10.1158/2159-8290.CD-17-0267
Published: 01 November 2017
View article titled, TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia
Open the PDF for TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

The Genomic Landscape of Pediatric Ewing Sarcoma

Brian D. Crompton, Chip Stewart, Amaro Taylor-Weiner, Gabriela Alexe, Kyle C. Kurek, Monica L. Calicchio, Adam Kiezun, Scott L. Carter, Sachet A. Shukla, Swapnil S. Mehta, Aaron R. Thorner, Carmen de Torres, Cinzia Lavarino, Mariona Suñol, Aaron McKenna, Andrey Sivachenko, Kristian Cibulskis, Michael S. Lawrence, Petar Stojanov, Mara Rosenberg, Lauren Ambrogio, Daniel Auclair, Sara Seepo, Brendan Blumenstiel, Matthew DeFelice, Ivan Imaz-Rosshandler, Angela Schwarz-Cruz y Celis, Miguel N. Rivera, Carlos Rodriguez-Galindo, Mark D. Fleming, Todd R. Golub, Gad Getz, Jaume Mora, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2014) 4 (11): 1326–1341.
https://doi.org/10.1158/2159-8290.CD-13-1037
Published: 01 November 2014
View article titled, The Genomic Landscape of Pediatric Ewing Sarcoma
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Includes: Supplementary data
Journal Articles

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Alexandre Puissant, Stacey M. Frumm, Gabriela Alexe, Christopher F. Bassil, Jun Qi, Yvan H. Chanthery, Erin A. Nekritz, Rhamy Zeid, William Clay Gustafson, Patricia Greninger, Matthew J. Garnett, Ultan McDermott, Cyril H. Benes, Andrew L. Kung, William A. Weiss, James E. Bradner, Kimberly Stegmaier
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 308–323.
https://doi.org/10.1158/2159-8290.CD-12-0418
Published: 07 March 2013
View article titled, Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
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Includes: Supplementary data