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Felix Y. Feng
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Journal Articles

High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes

Marina N. Sharifi, Jamie M. Sperger, Amy K. Taylor, Katharine E. Tippins, Shannon R. Reese, Viridiana Carreno, Katherine R. Kaufmann, Alex H. Chang, Luke A. Nunamaker, Charlotte Linebarger, Leilani Mora-Rodriguez, Jennifer L. Schehr, Hannah M. Krause, Kyle T. Helzer, Matthew L. Bootsma, Grace C. Blitzer, John M. Floberg, Christos E. Kyriakopoulos, Hamid Emamekhoo, Elisabeth I. Heath, Meghan Wells, Scott T. Tagawa, Martin Sjöström, Atish D. Choudhury, Menggang Yu, Andrew J. Armstrong, Dana E. Rathkopf, Himisha Beltran, Peter S. Nelson, Felix Y. Feng, Scott M. Dehm, David Kosoff, Xiao X. Wei, Rana R. McKay, Shuang G. Zhao, Joshua M. Lang
Journal: Cancer Discovery
Cancer Discov OF1–OF19.
https://doi.org/10.1158/2159-8290.CD-24-1509
Published: 01 April 2025
View articletitled, High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
Open the PDF for High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes in another window
Includes: Supplementary data
Journal Articles

Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer

Lisa N. Chesner, Fanny Polesso, Julie N. Graff, Jessica E. Hawley, Alexis K. Smith, Arian Lundberg, Rajdeep Das, Tanushree Shenoy, Martin Sjöström, Faming Zhao, Ya-Mei Hu, Simon Linder, William S. Chen, Reed M. Hawkins, Raunak Shrestha, Xiaolin Zhu, Adam Foye, Haolong Li, Lisa M. Kim, Megha Bhalla, Thomas O’loughlin, Duygu Kuzuoglu-Ozturk, Junjie T. Hua, Michelle L. Badura, Scott Wilkinson, Shana Y. Trostel, Andries M. Bergman, Davide Ruggero, Charles G. Drake, Adam G. Sowalsky, Lawrence Fong, Matthew R. Cooperberg, Wilbert Zwart, Xiangnan Guan, Alan Ashworth, Zheng Xia, David A. Quigley, Luke A. Gilbert, Felix Y. Feng, Amy E. Moran
Journal: Cancer Discovery
Cancer Discov (2025) 15 (3): 481–494.
https://doi.org/10.1158/2159-8290.CD-24-0559
Published: 03 March 2025
View articletitled, Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer
Open the PDF for Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

Yaru Xu, Yuqiu Yang, Zhaoning Wang, Martin Sjöström, Yuyin Jiang, Yitao Tang, Siyuan Cheng, Su Deng, Choushi Wang, Julisa Gonzalez, Nickolas A. Johnson, Xiang Li, Xiaoling Li, Lauren A. Metang, Atreyi Mukherji, Quanhui Xu, Carla R. Tirado, Garrett Wainwright, Xinzhe Yu, Spencer Barnes, Mia Hofstad, Yu Chen, Hong Zhu, Ariella B. Hanker, Ganesh V. Raj, Guanghui Zhu, Housheng H. He, Zhao Wang, Carlos L. Arteaga, Han Liang, Felix Y. Feng, Yunguan Wang, Tao Wang, Ping Mu
Journal: Cancer Discovery
Cancer Discov (2024) 14 (8): 1496–1521.
https://doi.org/10.1158/2159-8290.CD-23-0539
Published: 02 August 2024
View articletitled, ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Open the PDF for ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation

Gian Marco Franceschini, Orsetta Quaini, Kei Mizuno, Francesco Orlando, Yari Ciani, Sheng-Yu Ku, Michael Sigouros, Emily Rothmann, Alicia Alonso, Matteo Benelli, Caterina Nardella, Joonghoon Auh, Dory Freeman, Brian Hanratty, Mohamed Adil, Olivier Elemento, Scott T. Tagawa, Felix Y. Feng, Orazio Caffo, Consuelo Buttigliero, Umberto Basso, Peter S. Nelson, Eva Corey, Michael C. Haffner, Gerhardt Attard, Ana Aparicio, Francesca Demichelis, Himisha Beltran
Journal: Cancer Discovery
Cancer Discov (2024) 14 (3): 424–445.
https://doi.org/10.1158/2159-8290.CD-23-0754
Published: 01 March 2024
View articletitled, Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation
Open the PDF for Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation in another window
Includes: Supplementary data
Journal Articles

Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

Simon Linder, Marlous Hoogstraat, Suzan Stelloo, Nils Eickhoff, Karianne Schuurman, Hilda de Barros, Maartje Alkemade, Elise M. Bekers, Tesa M. Severson, Joyce Sanders, Chia-Chi Flora Huang, Tunc Morova, Umut Berkay Altintas, Liesbeth Hoekman, Yongsoo Kim, Sylvan C. Baca, Martin Sjöström, Anniek Zaalberg, Dorine C. Hintzen, Jeroen de Jong, Roelof J.C. Kluin, Iris de Rink, Claudia Giambartolomei, Ji-Heui Seo, Bogdan Pasaniuc, Maarten Altelaar, René H. Medema, Felix Y. Feng, Amina Zoubeidi, Matthew L. Freedman, Lodewyk F.A. Wessels, Lisa M. Butler, Nathan A. Lack, Henk van der Poel, Andries M. Bergman, Wilbert Zwart
Journal: Cancer Discovery
Cancer Discov (2022) 12 (9): 2074–2097.
https://doi.org/10.1158/2159-8290.CD-21-0576
Published: 02 September 2022
View articletitled, Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence
Open the PDF for Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence in another window
Includes: Supplementary data
Journal Articles

Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy

Jonathan Chou, David A. Quigley, Troy M. Robinson, Felix Y. Feng, Alan Ashworth
Journal: Cancer Discovery
Cancer Discov (2020) 10 (3): 351–370.
https://doi.org/10.1158/2159-8290.CD-19-0528
Published: 03 March 2020
View articletitled, Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy
Open the PDF for Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy in another window
Includes: Supplementary data
Journal Articles

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

David Quigley, Joshi J. Alumkal, Alexander W. Wyatt, Vishal Kothari, Adam Foye, Paul Lloyd, Rahul Aggarwal, Won Kim, Eric Lu, Jacob Schwartzman, Kevin Beja, Matti Annala, Rajdeep Das, Morgan Diolaiti, Colin Pritchard, George Thomas, Scott Tomlins, Karen Knudsen, Christopher J. Lord, Charles Ryan, Jack Youngren, Tomasz M. Beer, Alan Ashworth, Eric J. Small, Felix Y. Feng
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (9): 999–1005.
https://doi.org/10.1158/2159-8290.CD-17-0146
Published: 31 August 2017
View articletitled, Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors
Open the PDF for Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult

Jonathan F. Goodwin, Matthew J. Schiewer, Jeffry L. Dean, Randy S. Schrecengost, Renée de Leeuw, Sumin Han, Teng Ma, Robert B. Den, Adam P. Dicker, Felix Y. Feng, Karen E. Knudsen
Journal: Cancer Discovery
Cancer Discov (2013) 3 (11): 1254–1271.
https://doi.org/10.1158/2159-8290.CD-13-0108
Published: 06 November 2013
View articletitled, A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Open the PDF for A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult in another window
Includes: Supplementary data
Journal Articles

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

Yi-Mi Wu, Fengyun Su, Shanker Kalyana-Sundaram, Nickolay Khazanov, Bushra Ateeq, Xuhong Cao, Robert J. Lonigro, Pankaj Vats, Rui Wang, Su-Fang Lin, Ann-Joy Cheng, Lakshmi P. Kunju, Javed Siddiqui, Scott A. Tomlins, Peter Wyngaard, Seth Sadis, Sameek Roychowdhury, Maha H. Hussain, Felix Y. Feng, Mark M. Zalupski, Moshe Talpaz, Kenneth J. Pienta, Daniel R. Rhodes, Dan R. Robinson, Arul M. Chinnaiyan
Journal: Cancer Discovery
Cancer Discov (2013) 3 (6): 636–647.
https://doi.org/10.1158/2159-8290.CD-13-0050
Published: 06 June 2013
View articletitled, Identification of Targetable FGFR Gene Fusions in Diverse Cancers
Open the PDF for Identification of Targetable FGFR Gene Fusions in Diverse Cancers in another window
Includes: Supplementary data
Journal Articles

Dual Roles of PARP-1 Promote Cancer Growth and Progression

Matthew J. Schiewer, Jonathan F. Goodwin, Sumin Han, J. Chad Brenner, Michael A. Augello, Jeffry L. Dean, Fengzhi Liu, Jamie L. Planck, Preethi Ravindranathan, Arul M. Chinnaiyan, Peter McCue, Leonard G. Gomella, Ganesh V. Raj, Adam P. Dicker, Jonathan R. Brody, John M. Pascal, Margaret M. Centenera, Lisa M. Butler, Wayne D. Tilley, Felix Y. Feng, Karen E. Knudsen
Journal: Cancer Discovery
Cancer Discov (2012) 2 (12): 1134–1149.
https://doi.org/10.1158/2159-8290.CD-12-0120
Published: 09 December 2012
View articletitled, Dual Roles of PARP-1 Promote Cancer Growth and Progression
Open the PDF for Dual Roles of PARP-1 Promote Cancer Growth and Progression in another window
Includes: Supplementary data