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Eytan Ruppin
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Journal Articles

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations

Mei Luo, Jingwen Yang, Alejandro A. Schäffer, Chengxuan Chen, Yuan Liu, Yamei Chen, Chunru Lin, Lixia Diao, Yong Zang, Yanyan Lou, Huda Salman, Gordon B. Mills, Eytan Ruppin, Leng Han
Journal: Cancer Discovery
Cancer Discov (2025) 15 (3): 511–529.
https://doi.org/10.1158/2159-8290.CD-24-0827
Published: 03 March 2025
View article titled, Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations
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Includes: Supplementary data
Journal Articles

Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma

Sapir Cohen Shvefel, Joy A. Pai, Yingying Cao, Lipika R. Pal, Osnat Bartok, Ronen Levy, Marie J. Zemanek, Chen Weller, Ella Herzog, Winnie Yao, Kamir J. Hiam-Galvez, Kuoyuan Cheng, Yajie Yin, Peter P. Du, Colin J. Raposo, Nofar Gumpert, Michele Welti, Julia M. Martínez Gómez, Federica Sella, Elizabeta Yakubovich, Irit Orr, Shifra Ben-Dor, Roni Oren, Liat Fellus-Alyagor, Ofra Golani, Ori Jacob Brenner, Tomer M. Salame, Mirie Zerbib, Inna Goliand, Dean Ranmar, Ilya Savchenko, Nadav Ketrarou, Alejandro A. Schäffer, Rony Dahan, Mitchell P. Levesque, Eytan Ruppin, Ansuman T. Satpathy, Yardena Samuels
Journal: Cancer Discovery
Cancer Discov (2025) 15 (3): 553–577.
https://doi.org/10.1158/2159-8290.CD-23-1422
Published: 03 March 2025
View article titled, Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
Open the PDF for Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma in another window
Includes: Supplementary data
Journal Articles

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad D. Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tiangen Chang, Emma M. Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mülleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, Francesco Nicassio, Eytan Ruppin, Markus Ralser, Francisca Vazquez, Stefano Santaguida, Uri Ben-David
Journal: Cancer Discovery
Cancer Discov (2024) 14 (12): 2532–2553.
https://doi.org/10.1158/2159-8290.CD-23-0309
Published: 02 December 2024
View article titled, Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells
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Includes: Supplementary data
Journal Articles

AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer

Ashish Noronha, Nishanth Belugali Nataraj, Joo Sang Lee, Benny Zhitomirsky, Yaara Oren, Sara Oster, Moshit Lindzen, Saptaparna Mukherjee, Rainer Will, Soma Ghosh, Arturo Simoni-Nieves, Aakanksha Verma, Rishita Chatterjee, Simone Borgoni, Welles Robinson, Sanju Sinha, Alexander Brandis, D. Lucas Kerr, Wei Wu, Arunachalam Sekar, Suvendu Giri, Youngmin Chung, Diana Drago-Garcia, Brian P. Danysh, Mattia Lauriola, Michelangelo Fiorentino, Andrea Ardizzoni, Moshe Oren, Collin M. Blakely, Jideofor Ezike, Stefan Wiemann, Laxmi Parida, Trever G. Bivona, Rami I. Aqeilan, Joan S. Brugge, Aviv Regev, Gad Getz, Eytan Ruppin, Yosef Yarden
Journal: Cancer Discovery
Cancer Discov (2022) 12 (11): 2666–2683.
https://doi.org/10.1158/2159-8290.CD-22-0111
Published: 02 November 2022
View article titled, AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
Open the PDF for AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti–PD-1 Therapy

Kun Wang, Sushant Patkar, Joo Sang Lee, E. Michael Gertz, Welles Robinson, Fiorella Schischlik, David R. Crawford, Alejandro A. Schäffer, Eytan Ruppin
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1088–1105.
https://doi.org/10.1158/2159-8290.CD-21-0887
Published: 01 April 2022
View article titled, Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti–PD-1 Therapy
Open the PDF for Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti–PD-1 Therapy in another window
Includes: Supplementary data
Journal Articles

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Shelly Kalaora, Yochai Wolf, Tali Feferman, Eilon Barnea, Erez Greenstein, Dan Reshef, Itay Tirosh, Alexandre Reuben, Sushant Patkar, Ronen Levy, Juliane Quinkhardt, Tana Omokoko, Nouar Qutob, Ofra Golani, Jianhua Zhang, Xizeng Mao, Xingzhi Song, Chantale Bernatchez, Cara Haymaker, Marie-Andrée Forget, Caitlin Creasy, Polina Greenberg, Brett W. Carter, Zachary A. Cooper, Steven A. Rosenberg, Michal Lotem, Ugur Sahin, Guy Shakhar, Eytan Ruppin, Jennifer A. Wargo, Nir Friedman, Arie Admon, Yardena Samuels
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (11): 1366–1375.
https://doi.org/10.1158/2159-8290.CD-17-1418
Published: 01 November 2018
View article titled, Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma
Open the PDF for Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma in another window
Includes: Multimedia, Supplementary data