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Journal Articles

A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention

Norihiro Yamaguchi, Y. Gloria Wu, Ethan Ravetch, Mai Takahashi, Abdul G. Khan, Akimasa Hayashi, Wenbin Mei, Dennis Hsu, Shigeaki Umeda, Elisa de Stanchina, Ivo C. Lorenz, Christine A. Iacobuzio-Donahue, Sohail F. Tavazoie
Journal: Cancer Discovery
Cancer Discov (2024) 14 (12): 2489–2508.
https://doi.org/10.1158/2159-8290.CD-23-1323
Published: 02 December 2024
View articletitled, A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention
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Includes: Supplementary data
Journal Articles

A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer

Anupriya Singhal, Hannah C. Styers, Jonathan Rub, Zhuxuan Li, Stefan R. Torborg, Jung Yun Kim, Olivera Grbovic-Huezo, Huijin Feng, Zeynep Cagla Tarcan, Hulya Sahin Ozkan, Jill Hallin, Olca Basturk, Rona Yaeger, James G. Christensen, Doron Betel, Yan Yan, Iok In Christine Chio, Elisa de Stanchina, Tuomas Tammela
Journal: Cancer Discovery
Cancer Discov (2024) 14 (11): 2122–2134.
https://doi.org/10.1158/2159-8290.CD-24-0740
Published: 01 November 2024
View articletitled, A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy

Yaniv Kazansky, Daniel Cameron, Helen S. Mueller, Phillip Demarest, Nadia Zaffaroni, Noemi Arrighetti, Valentina Zuco, Yasumichi Kuwahara, Romel Somwar, Marc Ladanyi, Rui Qu, Elisa de Stanchina, Filemon S. Dela Cruz, Andrew L. Kung, Mrinal M. Gounder, Alex Kentsis
Journal: Cancer Discovery
Cancer Discov (2024) 14 (6): 965–981.
https://doi.org/10.1158/2159-8290.CD-23-0110
Published: 03 June 2024
View articletitled, Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy
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Includes: Supplementary data
Journal Articles

Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin, Ting-Hsiang Huang, Emily Montal, Yilun Ma, Nelly M Cruz, Xinran Tang, Jérémie Nsengimana, Julia Newton-Bishop, Miranda V. Hunter, Yuxin Zhu, Kevin Chen, Elisa de Stanchina, David J. Adams, Richard M. White
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 194–215.
https://doi.org/10.1158/2159-8290.CD-22-0427
Published: 09 January 2023
View articletitled, Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
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Includes: Supplementary data
Journal Articles

Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer

Rona Yaeger, Riccardo Mezzadra, Jenna Sinopoli, Yu Bian, Michelangelo Marasco, Esther Kaplun, Yijun Gao, HuiYong Zhao, Arnaud Da Cruz Paula, Yingjie Zhu, Almudena Chaves Perez, Kalyani Chadalavada, Edison Tse, Sudhir Chowdhry, Sydney Bowker, Qing Chang, Besnik Qeriqi, Britta Weigelt, Gouri J. Nanjangud, Michael F. Berger, Hirak Der-Torossian, Kenna Anderes, Nicholas D. Socci, Jinru Shia, Gregory J. Riely, Yonina R. Murciano-Goroff, Bob T. Li, James G. Christensen, Jorge S. Reis-Filho, David B. Solit, Elisa de Stanchina, Scott W. Lowe, Neal Rosen, Sandra Misale
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 41–55.
https://doi.org/10.1158/2159-8290.CD-22-0405
Published: 09 January 2023
View articletitled, Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 146–169.
https://doi.org/10.1158/2159-8290.CD-22-0416
Published: 09 January 2023
View articletitled, A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition
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Includes: Supplementary data
Journal Articles

Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements

Alison M. Schram, Igor Odintsov, Madelyn Espinosa-Cotton, Inna Khodos, Whitney J. Sisso, Marissa S. Mattar, Allan J.W. Lui, Morana Vojnic, Sara H. Shameem, Thrusha Chauhan, Jean Torrisi, Jim Ford, Marie N. O'Connor, Cecile A.W. Geuijen, Ron C.J. Schackmann, Jeroen J. Lammerts van Bueren, Ernesto Wasserman, Elisa de Stanchina, Eileen M. O'Reilly, Marc Ladanyi, Alexander Drilon, Romel Somwar
Journal: Cancer Discovery
Cancer Discov (2022) 12 (5): 1233–1247.
https://doi.org/10.1158/2159-8290.CD-21-1119
Published: 02 May 2022
View articletitled, Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements
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Includes: Supplementary data
Journal Articles

Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer

Anup Kumar Biswas, Seoyoung Han, Yifan Tai, Wanchao Ma, Courtney Coker, S. Aidan Quinn, Ahmad Rushdi Shakri, Timothy James Zhong, Hanna Scholze, Galina G. Lagos, Angeliki Mela, Katia Manova-Todorova, Elisa de Stanchina, Adolfo A. Ferrando, Cathy Mendelsohn, Peter Canoll, Helena A. Yu, Paul K. Paik, Anjali Saqi, Catherine A. Shu, Mark G. Kris, Joan Massague, Swarnali Acharyya
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1002–1021.
https://doi.org/10.1158/2159-8290.CD-21-0910
Published: 01 April 2022
View articletitled, Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer
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Includes: Supplementary data
Journal Articles

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S. Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Katherine A. Donovan, Marta Palafox, Jorge S. Reis-Filho, Elisa de Stanchina, Eric S. Fischer, Neal Rosen, Violeta Serra, Andrew Koff, John D. Chodera, Nathanael S. Gray, Sarat Chandarlapaty
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 356–371.
https://doi.org/10.1158/2159-8290.CD-20-1726
Published: 01 February 2022
View articletitled, INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation

Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yingqian A. Zhan, Maysun M. Hasan, Shweta S. Chavan, Fanli Meng, Fathema Uddin, Parvathy Manoj, Mark T.A. Donoghue, Helen H. Won, Joseph M. Chan, Metamia Ciampricotti, Andrew Chow, Michael Offin, Jason C. Chang, Jordana Ray-Kirton, Sam E. Tischfield, Jacklynn Egger, Umesh K. Bhanot, Irina Linkov, Marina Asher, Sonali Sinha, Joachim Silber, Christine A. Iacobuzio-Donahue, Michael H. Roehrl, Travis J. Hollmann, Helena A. Yu, Juan Qiu, Elisa de Stanchina, Marina K. Baine, Natasha Rekhtman, John T. Poirier, Brian Loomis, Richard P. Koche, Charles M. Rudin, Triparna Sen
Journal: Cancer Discovery
Cancer Discov (2021) 11 (12): 3028–3047.
https://doi.org/10.1158/2159-8290.CD-20-1863
Published: 02 December 2021
View articletitled, Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation
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Includes: Supplementary data
Journal Articles

SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies

Mahesh Saqcena, Luis Javier Leandro-Garcia, Jesper L.V. Maag, Vatche Tchekmedyian, Gnana P. Krishnamoorthy, Prasanna P. Tamarapu, Vera Tiedje, Vincent Reuter, Jeffrey A. Knauf, Elisa de Stanchina, Bin Xu, Xiao-Hui Liao, Samuel Refetoff, Ronald Ghossein, Ping Chi, Alan L. Ho, Richard P. Koche, James A. Fagin
Journal: Cancer Discovery
Cancer Discov (2021) 11 (5): 1158–1175.
https://doi.org/10.1158/2159-8290.CD-20-0735
Published: 01 May 2021
View articletitled, SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies
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Includes: Supplementary data
Journal Articles

TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors

Emiliano Cocco, Ji Eun Lee, Srinivasaraghavan Kannan, Alison M. Schram, Helen H. Won, Sophie Shifman, Amanda Kulick, Laura Baldino, Eneda Toska, Amaia Arruabarrena-Aristorena, Srushti Kittane, Fan Wu, Yanyan Cai, Sabrina Arena, Benedetta Mussolin, Ram Kannan, Neil Vasan, Alexander N. Gorelick, Michael F. Berger, Ofra Novoplansky, Sankar Jagadeeshan, Yi Liao, Uwe Rix, Sandra Misale, Barry S. Taylor, Alberto Bardelli, Jaclyn F. Hechtman, David M. Hyman, Moshe Elkabets, Elisa de Stanchina, Chandra S. Verma, Andrea Ventura, Alexander Drilon, Maurizio Scaltriti
Journal: Cancer Discovery
Cancer Discov (2021) 11 (1): 126–141.
https://doi.org/10.1158/2159-8290.CD-20-0571
Published: 06 January 2021
View articletitled, TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Bob T. Li, Neal Rosen, Federica Di Nicolantonio, Alberto Bardelli, Sandra Misale
Journal: Cancer Discovery
Cancer Discov (2020) 10 (8): 1129–1139.
https://doi.org/10.1158/2159-8290.CD-20-0187
Published: 03 August 2020
View articletitled, EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis

Josef Leibold, Marcus Ruscetti, Zhen Cao, Yu-Jui Ho, Timour Baslan, Min Zou, Wassim Abida, Judith Feucht, Teng Han, Francisco M. Barriga, Kaloyan M. Tsanov, Leah Zamechek, Amanda Kulick, Corina Amor, Sha Tian, Katarzyna Rybczyk, Nelson R. Salgado, Francisco J. Sánchez-Rivera, Philip A. Watson, Elisa de Stanchina, John E. Wilkinson, Lukas E. Dow, Cory Abate-Shen, Charles L. Sawyers, Scott W. Lowe
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (7): 1038–1057.
https://doi.org/10.1158/2159-8290.CD-19-1242
Published: 01 July 2020
View articletitled, Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis
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Includes: Supplementary data
Journal Articles

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers

Bob T. Li, Flavia Michelini, Sandra Misale, Emiliano Cocco, Laura Baldino, Yanyan Cai, Sophie Shifman, Hai-Yan Tu, Mackenzie L. Myers, Chongrui Xu, Marissa Mattar, Inna Khodos, Megan Little, Besnik Qeriqi, Gregory Weitsman, Clare J. Wilhem, Alshad S. Lalani, Irmina Diala, Rachel A. Freedman, Nancy U. Lin, David B. Solit, Michael F. Berger, Paul R. Barber, Tony Ng, Michael Offin, James M. Isbell, David R. Jones, Helena A. Yu, Sheeno Thyparambil, Wei-Li Liao, Anuja Bhalkikar, Fabiola Cecchi, David M. Hyman, Jason S. Lewis, Darren J. Buonocore, Alan L. Ho, Vicky Makker, Jorge S. Reis-Filho, Pedram Razavi, Maria E. Arcila, Mark G. Kris, John T. Poirier, Ronglai Shen, Junji Tsurutani, Gary A. Ulaner, Elisa de Stanchina, Neal Rosen, Charles M. Rudin, Maurizio Scaltriti
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (5): 674–687.
https://doi.org/10.1158/2159-8290.CD-20-0215
Published: 01 May 2020
View articletitled, HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers
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Includes: Supplementary data
Journal Articles

Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma

Patrizia Mondello, Saber Tadros, Matt Teater, Lorena Fontan, Aaron Y. Chang, Neeraj Jain, Haopeng Yang, Shailbala Singh, Hsia-Yuan Ying, Chi-Shuen Chu, Man Chun John Ma, Eneda Toska, Stefan Alig, Matthew Durant, Elisa de Stanchina, Sreejoyee Ghosh, Anja Mottok, Loretta Nastoupil, Sattva S. Neelapu, Oliver Weigert, Giorgio Inghirami, José Baselga, Anas Younes, Cassian Yee, Ahmet Dogan, David A. Scheinberg, Robert G. Roeder, Ari M. Melnick, Michael R. Green
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (3): 440–459.
https://doi.org/10.1158/2159-8290.CD-19-0116
Published: 03 March 2020
View articletitled, Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma
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Includes: Supplementary data
Journal Articles

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Yijun Gao, Ann Maria, Na Na, Arnaud da Cruz Paula, Alexander N. Gorelick, Jaclyn F. Hechtman, Julianne Carson, Robert A. Lefkowitz, Britta Weigelt, Barry S. Taylor, HuiYong Zhao, Jorge S. Reis-Filho, Elisa de Stanchina, Neal Rosen, Zhan Yao, Rona Yaeger
Journal: Cancer Discovery
Cancer Discov (2019) 9 (9): 1182–1191.
https://doi.org/10.1158/2159-8290.CD-19-0356
Published: 03 September 2019
View articletitled, V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer
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Includes: Supplementary data
Journal Articles

EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer

Francisco Sanchez-Vega, Jaclyn F. Hechtman, Pau Castel, Geoffrey Y. Ku, Yaelle Tuvy, Helen Won, Christopher J. Fong, Nancy Bouvier, Gouri J. Nanjangud, Joanne Soong, Efsevia Vakiani, Mark Schattner, David P. Kelsen, Robert A. Lefkowitz, Karen Brown, Mario E. Lacouture, Marinela Capanu, Marissa Mattar, Besnik Qeriqi, Fabiola Cecchi, Yuan Tian, Todd Hembrough, Rebecca J. Nagy, Richard B. Lanman, Steven M. Larson, Neeta Pandit-Taskar, Heiko Schöder, Christine A. Iacobuzio-Donahue, David H. Ilson, Wolfgang A. Weber, Michael F. Berger, Elisa de Stanchina, Barry S. Taylor, Jason S. Lewis, David B. Solit, Jorge A. Carrasquillo, Maurizio Scaltriti, Nikolaus Schultz, Yelena Y. Janjigian
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (2): 199–209.
https://doi.org/10.1158/2159-8290.CD-18-0598
Published: 08 February 2019
View articletitled, EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B. Ficarro, Peter Romanienko, Willie Mark, Craig McCarthy, Elisa de Stanchina, Mithat Gonen, Venkatraman Seshan, Patrick Bhola, Conor O'Donnell, Barbara Spitzer, Crystal Stutzke, Vincent-Philippe Lavallée, Josée Hébert, Andrei V. Krivtsov, Ari Melnick, Elisabeth M. Paietta, Martin S. Tallman, Anthony Letai, Guy Sauvageau, Gayle Pouliot, Ross Levine, Jarrod A Marto, Scott A. Armstrong, Alex Kentsis
Journal: Cancer Discovery
Cancer Discov (2018) 8 (4): 478–497.
https://doi.org/10.1158/2159-8290.CD-17-1271
Published: 01 April 2018
View articletitled, MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists

Weiyi Toy, Hazel Weir, Pedram Razavi, Mandy Lawson, Anne U. Goeppert, Anne Marie Mazzola, Aaron Smith, Joanne Wilson, Christopher Morrow, Wai Lin Wong, Elisa De Stanchina, Kathryn E. Carlson, Teresa S. Martin, Sharmeen Uddin, Zhiqiang Li, Sean Fanning, John A. Katzenellenbogen, Geoffrey Greene, José Baselga, Sarat Chandarlapaty
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (3): 277–287.
https://doi.org/10.1158/2159-8290.CD-15-1523
Published: 05 March 2017
View articletitled, Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists
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Includes: Supplementary data