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Dennie T. Frederick
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Journal Articles

Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2

Gretchen M. Alicea, Vito W. Rebecca, Aaron R. Goldman, Mitchell E. Fane, Stephen M. Douglass, Reeti Behera, Marie R. Webster, Curtis H. Kugel, III, Brett L. Ecker, M. Cecilia Caino, Andrew V. Kossenkov, Hsin-Yao Tang, Dennie T. Frederick, Keith T. Flaherty, Xiaowei Xu, Qin Liu, Dmitry I. Gabrilovich, Meenhard Herlyn, Ian A. Blair, Zachary T. Schug, David W. Speicher, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2020) 10 (9): 1282–1295.
https://doi.org/10.1158/2159-8290.CD-20-0329
Published: 01 September 2020
View article titled, Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
Open the PDF for Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2 in another window
Includes: Multimedia, Supplementary data
Journal Articles

ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma

Rani Ojha, Nektaria M. Leli, Angelique Onorati, Shengfu Piao, Ioannis I. Verginadis, Feven Tameire, Vito W. Rebecca, Cynthia I. Chude, Sengottuvelan Murugan, Colin Fennelly, Estela Noguera-Ortega, Charleen T. Chu, Shujing Liu, Xiaowei Xu, Clemens Krepler, Min Xiao, Wei Xu, Zhi Wei, Dennie T. Frederick, Genevieve Boland, Tara C. Mitchell, Giorgos C. Karakousis, Lynn M. Schuchter, Keith T. Flaherty, Gao Zhang, Meenhard Herlyn, Constantinos Koumenis, Ravi K. Amaravadi
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (3): 396–415.
https://doi.org/10.1158/2159-8290.CD-18-0348
Published: 01 March 2019
View article titled, ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma
Open the PDF for ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma in another window
Includes: Multimedia, Supplementary data
Journal Articles

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

Miles A. Miller, Madeleine J. Oudin, Ryan J. Sullivan, Stephanie J. Wang, Aaron S. Meyer, Hyungsoon Im, Dennie T. Frederick, Jenny Tadros, Linda G. Griffith, Hakho Lee, Ralph Weissleder, Keith T. Flaherty, Frank B. Gertler, Douglas A. Lauffenburger
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (4): 382–399.
https://doi.org/10.1158/2159-8290.CD-15-0933
Published: 03 April 2016
View article titled, Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance
Open the PDF for Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance in another window
Includes: Supplementary data
Journal Articles

EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma

Benchun Miao, Zhenyu Ji, Li Tan, Michael Taylor, Jianming Zhang, Hwan Geun Choi, Dennie T. Frederick, Raj Kumar, Jennifer A. Wargo, Keith T. Flaherty, Nathanael S. Gray, Hensin Tsao
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 274–287.
https://doi.org/10.1158/2159-8290.CD-14-0295
Published: 05 March 2015
View article titled, EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma
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Includes: Supplementary data
Journal Articles

The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα

Michael P. Smith, Berta Sanchez-Laorden, Kate O'Brien, Holly Brunton, Jennifer Ferguson, Helen Young, Nathalie Dhomen, Keith T. Flaherty, Dennie T. Frederick, Zachary A. Cooper, Jennifer A. Wargo, Richard Marais, Claudia Wellbrock
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (10): 1214–1229.
https://doi.org/10.1158/2159-8290.CD-13-1007
Published: 30 September 2014
View article titled, The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα
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Includes: Supplementary data
Journal Articles

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

David J. Konieczkowski, Cory M. Johannessen, Omar Abudayyeh, Jong Wook Kim, Zachary A. Cooper, Adriano Piris, Dennie T. Frederick, Michal Barzily-Rokni, Ravid Straussman, Rizwan Haq, David E. Fisher, Jill P. Mesirov, William C. Hahn, Keith T. Flaherty, Jennifer A. Wargo, Pablo Tamayo, Levi A. Garraway
Journal: Cancer Discovery
Cancer Discov (2014) 4 (7): 816–827.
https://doi.org/10.1158/2159-8290.CD-13-0424
Published: 06 July 2014
View article titled, A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
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Includes: Supplementary data
Journal Articles

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition

Nikhil Wagle, Eliezer M. Van Allen, Daniel J. Treacy, Dennie T. Frederick, Zachary A. Cooper, Amaro Taylor-Weiner, Mara Rosenberg, Eva M. Goetz, Ryan J. Sullivan, Deborah N. Farlow, Dennis C. Friedrich, Kristin Anderka, Danielle Perrin, Cory M. Johannessen, Aaron McKenna, Kristian Cibulskis, Gregory Kryukov, Eran Hodis, Donald P. Lawrence, Sheila Fisher, Gad Getz, Stacey B. Gabriel, Scott L. Carter, Keith T. Flaherty, Jennifer A. Wargo, Levi A. Garraway
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (1): 61–68.
https://doi.org/10.1158/2159-8290.CD-13-0631
Published: 07 January 2014
View article titled, MAP Kinase Pathway Alterations in <em>BRAF</em>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
Open the PDF for MAP Kinase Pathway Alterations in <em>BRAF</em>-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2

Michael P. O'Connell, Katie Marchbank, Marie R. Webster, Alexander A. Valiga, Amanpreet Kaur, Adina Vultur, Ling Li, Meenhard Herlyn, Jessie Villanueva, Qin Liu, Xiangfan Yin, Sandy Widura, Janelle Nelson, Nivia Ruiz, Tura C. Camilli, Fred E. Indig, Keith T. Flaherty, Jennifer A. Wargo, Dennie T. Frederick, Zachary A. Cooper, Suresh Nair, Ravi K. Amaravadi, Lynn M. Schuchter, Giorgos C. Karakousis, Wei Xu, Xiaowei Xu, Ashani T. Weeraratna
Journal: Cancer Discovery
Cancer Discov (2013) 3 (12): 1378–1393.
https://doi.org/10.1158/2159-8290.CD-13-0005
Published: 01 December 2013
View article titled, Hypoxia Induces Phenotypic Plasticity and Therapy Resistance in Melanoma via the Tyrosine Kinase Receptors ROR1 and ROR2
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Includes: Supplementary data
Journal Articles

Elucidating Distinct Roles for NF1 in Melanomagenesis

Ophélia Maertens, Bryan Johnson, Pablo Hollstein, Dennie T. Frederick, Zachary A. Cooper, Ludwine Messiaen, Roderick T. Bronson, Martin McMahon, Scott Granter, Keith Flaherty, Jennifer A. Wargo, Richard Marais, Karen Cichowski
Journal: Cancer Discovery
Cancer Discov (2013) 3 (3): 338–349.
https://doi.org/10.1158/2159-8290.CD-12-0313
Published: 07 March 2013
View article titled, Elucidating Distinct Roles for <em>NF1</em> in Melanomagenesis
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Includes: Supplementary data