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David G. DeNardo
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Journal Articles

Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

Jad I. Belle, Devashish Sen, John M. Baer, Xiuting Liu, Varintra E. Lander, Jiayu Ye, Blake E. Sells, Brett L. Knolhoff, Ahmad Faiz, Liang-I Kang, Guhan Qian, Ryan C. Fields, Li Ding, Hyun Kim, Paolo P. Provenzano, Sheila A. Stewart, David G. DeNardo
Journal: Cancer Discovery
Cancer Discov (2024) 14 (7): 1324–1355.
https://doi.org/10.1158/2159-8290.CD-23-0428
Published: 01 July 2024
View article titled, Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression

Jiayu Ye, John M. Baer, Douglas V. Faget, Vasilios A. Morikis, Qihao Ren, Anupama Melam, Ana Paula Delgado, Xianmin Luo, Satarupa Mullick Bagchi, Jad I. Belle, Edward Campos, Michael Friedman, Deborah J. Veis, Erik S. Knudsen, Agnieszka K. Witkiewicz, Scott Powers, Gregory D. Longmore, David G. DeNardo, Sheila A. Stewart
Journal: Cancer Discovery
Cancer Discov (2024) 14 (7): 1302–1323.
https://doi.org/10.1158/2159-8290.CD-23-0426
Published: 01 July 2024
View article titled, Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression
Open the PDF for Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression in another window
Includes: Supplementary data
Journal Articles

“RIPping” off Pancreas Cancer's Blockage of Immune Surveillance

Xiuting Liu, Blake E. Sells, David G. DeNardo
Journal: Cancer Discovery
Cancer Discov (2024) 14 (2): 208–210.
https://doi.org/10.1158/2159-8290.CD-23-1361
Published: 08 February 2024
View article titled, “RIPping” off Pancreas Cancer's Blockage of Immune Surveillance
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Journal Articles

p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy

Douglas V. Faget, Xianmin Luo, Matthew J. Inkman, Qihao Ren, Xinming Su, Kai Ding, Michael R. Waters, Ganesh Kumar Raut, Gaurav Pandey, Paarth B. Dodhiawala, Renata Ramalho-Oliveira, Jiayu Ye, Thomas Cole, Bhavna Murali, Alexander Zheleznyak, Monica Shokeen, Kurt R. Weiss, Joseph B. Monahan, Carl J. DeSelm, Adrian V. Lee, Steffi Oesterreich, Katherine N. Weilbaecher, Jin Zhang, David G. DeNardo, Sheila A. Stewart
Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1454–1477.
https://doi.org/10.1158/2159-8290.CD-22-0907
Published: 02 June 2023
View article titled, p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy
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Includes: Supplementary data
Journal Articles

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade

Varintra E. Lander, Jad I. Belle, Natalie L. Kingston, John M. Herndon, Graham D. Hogg, Xiuting Liu, Liang-I Kang, Brett L. Knolhoff, Savannah J. Bogner, John M. Baer, Chong Zuo, Nicholas C. Borcherding, Daniel P. Lander, Cedric Mpoy, Jalen Scott, Michael Zahner, Buck E. Rogers, Julie K. Schwarz, Hyun Kim, David G. DeNardo
Journal: Cancer Discovery
Cancer Discov (2022) 12 (12): 2774–2799.
https://doi.org/10.1158/2159-8290.CD-22-0192
Published: 02 December 2022
View article titled, Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade
Open the PDF for Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

A Single-Cell Window into Pancreas Cancer Fibroblast Heterogeneity

Jad I. Belle, David G. DeNardo
Journal: Cancer Discovery
Cancer Discov (2019) 9 (8): 1001–1002.
https://doi.org/10.1158/2159-8290.CD-19-0576
Published: 01 August 2019
View article titled, A Single-Cell Window into Pancreas Cancer Fibroblast Heterogeneity
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Journal Articles

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

David G. DeNardo, Donal J. Brennan, Elton Rexhepaj, Brian Ruffell, Stephen L. Shiao, Stephen F. Madden, William M. Gallagher, Nikhil Wadhwani, Scott D. Keil, Sharfaa A. Junaid, Hope S. Rugo, E. Shelley Hwang, Karin Jirström, Brian L. West, Lisa M. Coussens
Journal: Cancer Discovery
Cancer Discov (2011) 1 (1): 54–67.
https://doi.org/10.1158/2159-8274.CD-10-0028
Published: 01 June 2011
View article titled, Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
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Includes: Supplementary data