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David A. Barbie
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Journal Articles

TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity

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Tetsuo Tani, Haritha Mathsyaraja, Marco Campisi, Ze-Hua Li, Koji Haratani, Caroline G. Fahey, Keiichi Ota, Navin R. Mahadevan, Yingxiao Shi, Shin Saito, Kei Mizuno, Tran C. Thai, Nobunari Sasaki, Mizuki Homme, Choudhury Fabliha B. Yusuf, Adam Kashishian, Jipsa Panchal, Min Wang, Benjamin J. Wolf, Thanh U. Barbie, Cloud P. Paweletz, Prafulla C. Gokhale, David Liu, Ravindra Uppaluri, Shunsuke Kitajima, Jennifer Cain, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2024) 14 (5): 752–765.
https://doi.org/10.1158/2159-8290.CD-23-0700
Published: 01 May 2024
View articletitled, TREX1 Inactivation Unleashes Cancer Cell STING–Interferon Signaling and Promotes Antitumor Immunity
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Includes: Supplementary data
Journal Articles

Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity

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Navin R. Mahadevan, Erik H. Knelson, Jacquelyn O. Wolff, Amir Vajdi, Maria Saigí, Marco Campisi, Deli Hong, Tran C. Thai, Brandon Piel, Saemi Han, Bruce B. Reinhold, Jonathan S. Duke-Cohan, Michael J. Poitras, Luke J. Taus, Patrick H. Lizotte, Andrew Portell, Victor Quadros, Alison D. Santucci, Takahiko Murayama, Israel Cañadas, Shunsuke Kitajima, Aoi Akitsu, Maya Fridrikh, Hideo Watanabe, Brendan Reardon, Prafulla C. Gokhale, Cloud P. Paweletz, Mark M. Awad, Eliezer M. Van Allen, Ana Lako, Xi-Tao Wang, Benjamin Chen, Fangxin Hong, Lynette M. Sholl, Michael Y. Tolstorukov, Kathleen Pfaff, Pasi A. Jänne, Evisa Gjini, Robin Edwards, Scott Rodig, Ellis L. Reinherz, Matthew G. Oser, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2021) 11 (8): 1952–1969.
https://doi.org/10.1158/2159-8290.CD-20-0913
Published: 01 August 2021
View articletitled, Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity
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Includes: Supplementary data
Journal Articles

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade

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Cécile Gstalder, David Liu, Diana Miao, Bart Lutterbach, Alexander L. DeVine, Chenyu Lin, Megha Shettigar, Priya Pancholi, Elizabeth I. Buchbinder, Scott L. Carter, Michael P. Manos, Vanesa Rojas-Rudilla, Ryan Brennick, Evisa Gjini, Pei-Hsuan Chen, Ana Lako, Scott Rodig, Charles H. Yoon, Gordon J. Freeman, David A. Barbie, F. Stephen Hodi, Wayne Miles, Eliezer M. Van Allen, Rizwan Haq
Journal: Cancer Discovery
Cancer Discov (2020) 10 (9): 1296–1311.
https://doi.org/10.1158/2159-8290.CD-19-1416
Published: 01 September 2020
View articletitled, Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade
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Includes: Supplementary data
Journal Articles

TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability

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Ziad Bakouny, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2020) 10 (3): 348–350.
https://doi.org/10.1158/2159-8290.CD-19-1525
Published: 03 March 2020
View articletitled, TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability
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Journal Articles

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

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Anna F. Farago, Beow Y. Yeap, Marcello Stanzione, Yin P. Hung, Rebecca S. Heist, J. Paul Marcoux, Jun Zhong, Deepa Rangachari, David A. Barbie, Sarah Phat, David T. Myers, Robert Morris, Marina Kem, Taronish D. Dubash, Elizabeth A. Kennedy, Subba R. Digumarthy, Lecia V. Sequist, Aaron N. Hata, Shyamala Maheswaran, Daniel A. Haber, Michael S. Lawrence, Alice T. Shaw, Mari Mino-Kenudson, Nicholas J. Dyson, Benjamin J. Drapkin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (10): 1372–1387.
https://doi.org/10.1158/2159-8290.CD-19-0582
Published: 01 October 2019
View articletitled, Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

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Shunsuke Kitajima, Elena Ivanova, Sujuan Guo, Ryohei Yoshida, Marco Campisi, Shriram K. Sundararaman, Shoichiro Tange, Yoichiro Mitsuishi, Tran C. Thai, Sayuri Masuda, Brandon P. Piel, Lynette M. Sholl, Paul T. Kirschmeier, Cloud P. Paweletz, Hideo Watanabe, Mamiko Yajima, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2019) 9 (1): 34–45.
https://doi.org/10.1158/2159-8290.CD-18-0689
Published: 09 January 2019
View articletitled, Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
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Includes: Supplementary data
Journal Articles

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

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Jiehui Deng, Eric S. Wang, Russell W. Jenkins, Shuai Li, Ruben Dries, Kathleen Yates, Sandeep Chhabra, Wei Huang, Hongye Liu, Amir R. Aref, Elena Ivanova, Cloud P. Paweletz, Michaela Bowden, Chensheng W. Zhou, Grit S. Herter-Sprie, Jessica A. Sorrentino, John E. Bisi, Patrick H. Lizotte, Ashley A. Merlino, Max M. Quinn, Lauren E. Bufe, Annan Yang, Yanxi Zhang, Hua Zhang, Peng Gao, Ting Chen, Megan E. Cavanaugh, Amanda J. Rode, Eric Haines, Patrick J. Roberts, Jay C. Strum, William G. Richards, Jochen H. Lorch, Sareh Parangi, Viswanath Gunda, Genevieve M. Boland, Raphael Bueno, Sangeetha Palakurthi, Gordon J. Freeman, Jerome Ritz, W. Nicholas Haining, Norman E. Sharpless, Haribabu Arthanari, Geoffrey I. Shapiro, David A. Barbie, Nathanael S. Gray, Kwok-Kin Wong
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 216–233.
https://doi.org/10.1158/2159-8290.CD-17-0915
Published: 04 February 2018
View articletitled, CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
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Includes: Supplementary data
Journal Articles

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

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Russell W. Jenkins, Amir R. Aref, Patrick H. Lizotte, Elena Ivanova, Susanna Stinson, Chensheng W. Zhou, Michaela Bowden, Jiehui Deng, Hongye Liu, Diana Miao, Meng Xiao He, William Walker, Gao Zhang, Tian Tian, Chaoran Cheng, Zhi Wei, Sangeetha Palakurthi, Mark Bittinger, Hans Vitzthum, Jong Wook Kim, Ashley Merlino, Max Quinn, Chandrasekar Venkataramani, Joshua A. Kaplan, Andrew Portell, Prafulla C. Gokhale, Bart Phillips, Alicia Smart, Asaf Rotem, Robert E. Jones, Lauren Keogh, Maria Anguiano, Lance Stapleton, Zhiheng Jia, Michal Barzily-Rokni, Israel Cañadas, Tran C. Thai, Marc R. Hammond, Raven Vlahos, Eric S. Wang, Hua Zhang, Shuai Li, Glenn J. Hanna, Wei Huang, Mai P. Hoang, Adriano Piris, Jean-Pierre Eliane, Anat O. Stemmer-Rachamimov, Lisa Cameron, Mei-Ju Su, Parin Shah, Benjamin Izar, Manisha Thakuria, Nicole R. LeBoeuf, Guilherme Rabinowits, Viswanath Gunda, Sareh Parangi, James M. Cleary, Brian C. Miller, Shunsuke Kitajima, Rohit Thummalapalli, Benchun Miao, Thanh U. Barbie, Vivek Sivathanu, Joshua Wong, William G. Richards, Raphael Bueno, Charles H. Yoon, Juan Miret, Meenhard Herlyn, Levi A. Garraway, Eliezer M. Van Allen, Gordon J. Freeman, Paul T. Kirschmeier, Jochen H. Lorch, Patrick A. Ott, F. Stephen Hodi, Keith T. Flaherty, Roger D. Kamm, Genevieve M. Boland, Kwok-Kin Wong, David Dornan, Cloud Peter Paweletz, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2018) 8 (2): 196–215.
https://doi.org/10.1158/2159-8290.CD-17-0833
Published: 04 February 2018
View articletitled, Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids
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Includes: Multimedia, Supplementary data
Journal Articles

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer

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Dennis O. Adeegbe, Yan Liu, Patrick H. Lizotte, Yusuke Kamihara, Amir R. Aref, Christina Almonte, Ruben Dries, Yuyang Li, Shengwu Liu, Xiaoen Wang, Tiquella Warner-Hatten, Jessica Castrillon, Guo-Cheng Yuan, Neermala Poudel-Neupane, Haikuo Zhang, Jennifer L. Guerriero, Shiwei Han, Mark M. Awad, David A. Barbie, Jerome Ritz, Simon S. Jones, Peter S. Hammerman, James Bradner, Steven N. Quayle, Kwok-Kin Wong
Journal: Cancer Discovery
Cancer Discov (2017) 7 (8): 852–867.
https://doi.org/10.1158/2159-8290.CD-16-1020
Published: 01 August 2017
View articletitled, Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

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Russell W. Jenkins, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2017) 7 (8): 799–801.
https://doi.org/10.1158/2159-8290.CD-17-0607
Published: 01 August 2017
View articletitled, Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma
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Journal Articles

Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit

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Zehua Zhu, Amir R. Aref, Travis J. Cohoon, Thanh U. Barbie, Yu Imamura, Shenghong Yang, Susan E. Moody, Rhine R. Shen, Anna C. Schinzel, Tran C. Thai, Jacob B. Reibel, Pablo Tamayo, Jason T. Godfrey, Zhi Rong Qian, Asher N. Page, Karolina Maciag, Edmond M. Chan, Whitney Silkworth, Mary T. Labowsky, Lior Rozhansky, Jill P. Mesirov, William E. Gillanders, Shuji Ogino, Nir Hacohen, Suzanne Gaudet, Michael J. Eck, Jeffrey A. Engelman, Ryan B. Corcoran, Kwok-Kin Wong, William C. Hahn, David A. Barbie
Journal: Cancer Discovery
Cancer Discov (2014) 4 (4): 452–465.
https://doi.org/10.1158/2159-8290.CD-13-0646
Published: 03 April 2014
View articletitled, Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit
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Includes: Supplementary data
Journal Articles

Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers

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Daniel Hagerstrand, Alexander Tong, Steven E. Schumacher, Nina Ilic, Rhine R. Shen, Hiu Wing Cheung, Francisca Vazquez, Yashaswi Shrestha, So Young Kim, Andrew O. Giacomelli, Joseph Rosenbluh, Anna C. Schinzel, Nicole A. Spardy, David A. Barbie, Craig H. Mermel, Barbara A. Weir, Levi A. Garraway, Pablo Tamayo, Jill P. Mesirov, Rameen Beroukhim, William C. Hahn
Journal: Cancer Discovery
Cancer Discov (2013) 3 (9): 1044–1057.
https://doi.org/10.1158/2159-8290.CD-12-0592
Published: 09 September 2013
View articletitled, Systematic Interrogation of 3q26 Identifies TLOC1 and SKIL as Cancer Drivers
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Includes: Supplementary data