1-7 of 7
Cynthia L. Sears
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice

Julia L. Drewes, Jie Chen, Nicholas O. Markham, Reece J. Knippel, Jada C. Domingue, Ada J. Tam, June L. Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M. Dejea, Sarah Tomkovich, John Michel, James R. White, Fuad Mohammad, Victoria L. Campodónico, Cody N. Heiser, Xinqun Wu, Shaoguang Wu, Hua Ding, Patricia Simner, Karen Carroll, Martha J. Shrubsole, Robert A. Anders, Seth T. Walk, Christian Jobin, Fengyi Wan, Robert J. Coffey, Franck Housseau, Ken S. Lau, Cynthia L. Sears
Journal: Cancer Discovery
Cancer Discov (2022) 12 (8): 1873–1885.
https://doi.org/10.1158/2159-8290.CD-21-1273
Published: 05 August 2022
View articletitled, Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
Open the PDF for Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice in another window
Includes: Supplementary data
Journal Articles

Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis

Yue Liu, Kai Fu, Eric M. Wier, Yifan Lei, Andrea Hodgson, Dongqing Xu, Xue Xia, Dandan Zheng, Hua Ding, Cynthia L. Sears, Jian Yang, Fengyi Wan
Journal: Cancer Discovery
Cancer Discov (2022) 12 (1): 236–249.
https://doi.org/10.1158/2159-8290.CD-21-0912
Published: 12 January 2022
View articletitled, Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis
Open the PDF for Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

The Cancer Microbiome: Recent Highlights and Knowledge Gaps

Reece J. Knippel, Julia L. Drewes, Cynthia L. Sears
Journal: Cancer Discovery
Cancer Discov (2021) 11 (10): 2378–2395.
https://doi.org/10.1158/2159-8290.CD-21-0324
Published: 01 October 2021
View articletitled, The Cancer Microbiome: Recent Highlights and Knowledge Gaps
Open the PDF for The Cancer Microbiome: Recent Highlights and Knowledge Gaps in another window
Journal Articles

Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy

Christina E. DeStefano Shields, James R. White, Liam Chung, Alyssa Wenzel, Jessica L. Hicks, Ada J. Tam, June L. Chan, Christine M. Dejea, Hongni Fan, John Michel, Ashley R. Maiuri, Shruthi Sriramkumar, Ram Podicheti, Douglas B. Rusch, Hao Wang, Angelo M. De Marzo, Sepideh Besharati, Robert A. Anders, Stephen B. Baylin, Heather M. O'Hagan, Franck Housseau, Cynthia L. Sears
Journal: Cancer Discovery
Cancer Discov (2021) 11 (7): 1792–1807.
https://doi.org/10.1158/2159-8290.CD-20-0770
Published: 01 July 2021
View articletitled, Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy
Open the PDF for Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy in another window
Includes: Supplementary data
Journal Articles

A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes

Sheetal Parida, Shaoguang Wu, Sumit Siddharth, Guannan Wang, Nethaji Muniraj, Arumugam Nagalingam, Christina Hum, Panagiotis Mistriotis, Haiping Hao, C. Conover Talbot, Jr, Konstantinos Konstantopoulos, Kathleen L. Gabrielson, Cynthia L. Sears, Dipali Sharma
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (5): 1138–1157.
https://doi.org/10.1158/2159-8290.CD-20-0537
Published: 01 May 2021
View articletitled, A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes
Open the PDF for A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes in another window
Includes: Supplementary data
Journal Articles

Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis

Abby L. Geis, Hongni Fan, Xinqun Wu, Shaoguang Wu, David L. Huso, Jaime L. Wolfe, Cynthia L. Sears, Drew M. Pardoll, Franck Housseau
Journal: Cancer Discovery
Cancer Discov (2015) 5 (10): 1098–1109.
https://doi.org/10.1158/2159-8290.CD-15-0447
Published: 30 September 2015
View articletitled, Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis
Open the PDF for Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis in another window
Includes: Supplementary data
Journal Articles

The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints

Nicolas J. Llosa, Michael Cruise, Ada Tam, Elizabeth C. Wicks, Elizabeth M. Hechenbleikner, Janis M. Taube, Richard L. Blosser, Hongni Fan, Hao Wang, Brandon S. Luber, Ming Zhang, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Cynthia L. Sears, Robert A. Anders, Drew M. Pardoll, Franck Housseau
Journal: Cancer Discovery
Cancer Discov (2015) 5 (1): 43–51.
https://doi.org/10.1158/2159-8290.CD-14-0863
Published: 11 January 2015
View articletitled, The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints
Open the PDF for The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints in another window
Includes: Supplementary data