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Costas A. Lyssiotis
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Journal Articles

The Hallmarks of Precancer

Mary M. Stangis, Zhengyi Chen, Jimin Min, Sarah E. Glass, Jordan O. Jackson, Megan D. Radyk, Xen Ping Hoi, W. Nathaniel Brennen, Ming Yu, Huy Q. Dinh, Robert J. Coffey, Martha J. Shrubsole, Keith S. Chan, William M. Grady, Srinivasan Yegnasubramanian, Costas A. Lyssiotis, Anirban Maitra, Richard B. Halberg, Neelendu Dey, Ken S. Lau
Journal: Cancer Discovery
Cancer Discov (2024) 14 (4): 683–689.
https://doi.org/10.1158/2159-8290.CD-23-1550
Published: 04 April 2024
View article titled, The Hallmarks of Precancer
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Journal Articles

GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress

Weihua Zhou, Zitong Zhao, Angelica Lin, John Z. Yang, Jie Xu, Kari Wilder-Romans, Annabel Yang, Jing Li, Sumeet Solanki, Jennifer M. Speth, Natalie Walker, Andrew J. Scott, Lu Wang, Bo Wen, Anthony Andren, Li Zhang, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Alexander Ullrich, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M. O’Brien, Ameer L. Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N. Al-Holou, Yoshie Umemura, Meredith A. Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Marc Peters-Golden, Yatrik M. Shah, Daniel R. Wahl
Journal: Cancer Discovery
Cancer Discov (2024) 14 (1): 158–175.
https://doi.org/10.1158/2159-8290.CD-23-0437
Published: 12 January 2024
View article titled, GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress
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Includes: Supplementary data
Journal Articles

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M. Waszak, Stefan R. Sweha, Mateus Mota, Matthew Pun, Akash Deogharkar, Chan Chung, Rohinton S. Tarapore, Samuel Ramage, Andrew Chi, Patrick Y. Wen, Isabel Arrillaga-Romany, Tracy T. Batchelor, Nicholas A. Butowski, Ashley Sumrall, Nicole Shonka, Rebecca A. Harrison, John de Groot, Minesh Mehta, Matthew D. Hall, Doured Daghistani, Timothy F. Cloughesy, Benjamin M. Ellingson, Kevin Beccaria, Pascale Varlet, Michelle M. Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Rajan Jain, Maureen Kachman, Heidi Baum, Charles F. Burant, Sophie L. Mottl, Rodrigo T. Cartaxo, Vishal John, Dana Messinger, Tingting Qin, Erik Peterson, Peter Sajjakulnukit, Karthik Ravi, Alyssa Waugh, Dustin Walling, Yujie Ding, Ziyun Xia, Anna Schwendeman, Debra Hawes, Fusheng Yang, Alexander R. Judkins, Daniel Wahl, Costas A. Lyssiotis, Daniel de la Nava, Marta M. Alonso, Augustine Eze, Jasper Spitzer, Susanne V. Schmidt, Ryan J. Duchatel, Matthew D. Dun, Jason E. Cain, Li Jiang, Sylwia A. Stopka, Gerard Baquer, Michael S. Regan, Mariella G. Filbin, Nathalie Y.R. Agar, Lili Zhao, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Ryo Kurokawa, Drew Pratt, Viveka N. Yadav, Jacques Grill, Cassie Kline, Sabine Mueller, Adam Resnick, Javad Nazarian, Joshua E. Allen, Yazmin Odia, Sharon L. Gardner, Carl Koschmann
Journal: Cancer Discovery
Cancer Discov (2023) 13 (11): 2370–2393.
https://doi.org/10.1158/2159-8290.CD-23-0131
Published: 01 November 2023
View article titled, Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
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Includes: Supplementary data
Journal Articles

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Francesca Puca, Fei Yu, Caterina Bartolacci, Piergiorgio Pettazzoni, Alessandro Carugo, Emmet Huang-Hobbs, Jintan Liu, Ciro Zanca, Federica Carbone, Edoardo Del Poggetto, Joy Gumin, Pushan Dasgupta, Sahil Seth, Sanjana Srinivasan, Frederick F. Lang, Erik P. Sulman, Philip L. Lorenzi, Lin Tan, Mengrou Shan, Zachary P. Tolstyka, Maureen Kachman, Li Zhang, Sisi Gao, Angela K. Deem, Giannicola Genovese, Pier Paolo Scaglioni, Costas A. Lyssiotis, Andrea Viale, Giulio F. Draetta
Journal: Cancer Discovery
Cancer Discov (2021) 11 (11): 2904–2923.
https://doi.org/10.1158/2159-8290.CD-20-1437
Published: 01 November 2021
View article titled, Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma
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Includes: Supplementary data
Journal Articles

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

Yaqing Zhang, Jenny Lazarus, Nina G. Steele, Wei Yan, Ho-Joon Lee, Zeribe C. Nwosu, Christopher J. Halbrook, Rosa E. Menjivar, Samantha B. Kemp, Veerin R. Sirihorachai, Ashley Velez-Delgado, Katelyn Donahue, Eileen S. Carpenter, Kristee L. Brown, Valerie Irizarry-Negron, Anna C. Nevison, Alekya Vinta, Michelle A. Anderson, Howard C. Crawford, Costas A. Lyssiotis, Timothy L. Frankel, Filip Bednar, Marina Pasca di Magliano
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (3): 422–439.
https://doi.org/10.1158/2159-8290.CD-19-0958
Published: 03 March 2020
View article titled, Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis
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Includes: Supplementary data
Journal Articles

Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors

Christopher J. Halbrook, Barbara S. Nelson, Costas A. Lyssiotis
Journal: Cancer Discovery
Cancer Discov (2019) 9 (3): 326–328.
https://doi.org/10.1158/2159-8290.CD-19-0034
Published: 01 March 2019
View article titled, Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors
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Journal Articles

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Anguraj Sadanandam, Stephan Wullschleger, Costas A. Lyssiotis, Carsten Grötzinger, Stefano Barbi, Samantha Bersani, Jan Körner, Ismael Wafy, Andrea Mafficini, Rita T. Lawlor, Michele Simbolo, John M. Asara, Hendrik Bläker, Lewis C. Cantley, Bertram Wiedenmann, Aldo Scarpa, Douglas Hanahan
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (12): 1296–1313.
https://doi.org/10.1158/2159-8290.CD-15-0068
Published: 03 December 2015
View article titled, A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics
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Includes: Supplementary data
Journal Articles

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

Ashish Juvekar, Laura N. Burga, Hai Hu, Elaine P. Lunsford, Yasir H. Ibrahim, Judith Balmañà, Anbazhagan Rajendran, Antonella Papa, Katherine Spencer, Costas A. Lyssiotis, Caterina Nardella, Pier Paolo Pandolfi, José Baselga, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf
Journal: Cancer Discovery
Cancer Discov (2012) 2 (11): 1048–1063.
https://doi.org/10.1158/2159-8290.CD-11-0336
Published: 11 November 2012
View article titled, Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
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Includes: Supplementary data