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Christopher J. Lord
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Journal Articles

Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial

Suzanne Carreira, Nuria Porta, Sara Arce-Gallego, George Seed, Alba Llop-Guevara, Diletta Bianchini, Pasquale Rescigno, Alec Paschalis, Claudia Bertan, Chloe Baker, Jane Goodall, Susana Miranda, Ruth Riisnaes, Ines Figueiredo, Ana Ferreira, Rita Pereira, Mateus Crespo, Bora Gurel, Daniel Nava Rodrigues, Stephen J. Pettitt, Wei Yuan, Violeta Serra, Jan Rekowski, Christopher J. Lord, Emma Hall, Joaquin Mateo, Johann S. de Bono
Journal: Cancer Discovery
Cancer Discov (2021) 11 (11): 2812–2827.
https://doi.org/10.1158/2159-8290.CD-21-0007
Published: 01 November 2021
View article titled, Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial
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Includes: Supplementary data
Journal Articles

Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non–BRCA1/2-Mutant Cancers

Timothy A. Yap, Rebecca Kristeleit, Vasiliki Michalarea, Stephen J. Pettitt, Joline S.J. Lim, Suzanne Carreira, Desamparados Roda, Rowan Miller, Ruth Riisnaes, Susana Miranda, Ines Figueiredo, Daniel Nava Rodrigues, Sarah Ward, Ruth Matthews, Mona Parmar, Alison Turner, Nina Tunariu, Neha Chopra, Heidrun Gevensleben, Nicholas C. Turner, Ruth Ruddle, Florence I. Raynaud, Shaun Decordova, Karen E. Swales, Laura Finneran, Emma Hall, Paul Rugman, Justin P.O. Lindemann, Andrew Foxley, Christopher J. Lord, Udai Banerji, Ruth Plummer, Bristi Basu, Juanita S. Lopez, Yvette Drew, Johann S. de Bono
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (10): 1528–1543.
https://doi.org/10.1158/2159-8290.CD-20-0163
Published: 01 October 2020
View article titled, Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with <em>BRCA1/2</em>- and Non–<em>BRCA1/2</em>-Mutant Cancers
Open the PDF for Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with <em>BRCA1/2</em>- and Non–<em>BRCA1/2</em>-Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance

Stephen J. Pettitt, Jessica R. Frankum, Marco Punta, Stefano Lise, John Alexander, Yi Chen, Timothy A. Yap, Syed Haider, Andrew N.J. Tutt, Christopher J. Lord
Journal: Cancer Discovery
Cancer Discov (2020) 10 (10): 1475–1488.
https://doi.org/10.1158/2159-8290.CD-19-1485
Published: 01 October 2020
View article titled, Clinical <em>BRCA1/2</em> Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance
Open the PDF for Clinical <em>BRCA1/2</em> Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance in another window
Includes: Supplementary data
Journal Articles

Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

Matthew G. Oser, Raquel Fonseca, Abhishek A. Chakraborty, Rachel Brough, Alexander Spektor, Rebecca B. Jennings, Abdallah Flaifel, Jesse S. Novak, Aditi Gulati, Elizabeth Buss, Scott T. Younger, Samuel K. McBrayer, Glenn S. Cowley, Dennis M. Bonal, Quang-De Nguyen, Laura Brulle-Soumare, Paula Taylor, Stefano Cairo, Colm J. Ryan, Elizabeth J. Pease, Kim Maratea, Jon Travers, David E. Root, Sabina Signoretti, David Pellman, Susan Ashton, Christopher J. Lord, Simon T. Barry, William G. Kaelin, Jr
Journal: Cancer Discovery
Cancer Discov (2019) 9 (2): 230–247.
https://doi.org/10.1158/2159-8290.CD-18-0389
Published: 08 February 2019
View article titled, Cells Lacking the <em>RB1</em> Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
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Includes: Supplementary data
Journal Articles

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N. Pemberton, Jessica Frankum, Feifei Song, Rumana Rafiq, Asha Konde, Dragomir B. Krastev, Malini Menon, James Campbell, Aditi Gulati, Rahul Kumar, Stephen J. Pettitt, Mark D. Gurden, Marta Llorca Cardenosa, Irene Chong, Patrycja Gazinska, Fredrik Wallberg, Elinor J. Sawyer, Lesley-Ann Martin, Mitch Dowsett, Spiros Linardopoulos, Rachael Natrajan, Colm J. Ryan, Patrick W.B. Derksen, Jos Jonkers, Andrew N.J. Tutt, Alan Ashworth, Christopher J. Lord
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (4): 498–515.
https://doi.org/10.1158/2159-8290.CD-17-0603
Published: 01 April 2018
View article titled, E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer
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Includes: Multimedia, Supplementary data
Journal Articles

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer

Rachael Natrajan, Andrew N.J. Tutt, Christopher J. Lord
Journal: Cancer Discovery
Cancer Discov (2018) 8 (3): 272–275.
https://doi.org/10.1158/2159-8290.CD-18-0091
Published: 01 March 2018
View article titled, Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer
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Journal Articles

Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Jane Goodall, Joaquin Mateo, Wei Yuan, Helen Mossop, Nuria Porta, Susana Miranda, Raquel Perez-Lopez, David Dolling, Dan R. Robinson, Shahneen Sandhu, Gemma Fowler, Berni Ebbs, Penny Flohr, George Seed, Daniel Nava Rodrigues, Gunther Boysen, Claudia Bertan, Mark Atkin, Matthew Clarke, Mateus Crespo, Ines Figueiredo, Ruth Riisnaes, Semini Sumanasuriya, Pasquale Rescigno, Zafeiris Zafeiriou, Adam Sharp, Nina Tunariu, Diletta Bianchini, Alexa Gillman, Christopher J. Lord, Emma Hall, Arul M. Chinnaiyan, Suzanne Carreira, Johann S. de Bono
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (9): 1006–1017.
https://doi.org/10.1158/2159-8290.CD-17-0261
Published: 31 August 2017
View article titled, Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition
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Includes: Supplementary data
Journal Articles

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

David Quigley, Joshi J. Alumkal, Alexander W. Wyatt, Vishal Kothari, Adam Foye, Paul Lloyd, Rahul Aggarwal, Won Kim, Eric Lu, Jacob Schwartzman, Kevin Beja, Matti Annala, Rajdeep Das, Morgan Diolaiti, Colin Pritchard, George Thomas, Scott Tomlins, Karen Knudsen, Christopher J. Lord, Charles Ryan, Jack Youngren, Tomasz M. Beer, Alan Ashworth, Eric J. Small, Felix Y. Feng
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (9): 999–1005.
https://doi.org/10.1158/2159-8290.CD-17-0146
Published: 31 August 2017
View article titled, Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of <em>BRCA2</em> Reversion Mutations Associated with Resistance to PARP Inhibitors
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Includes: Supplementary data
Journal Articles

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers

Johnathan Watkins, Daniel Weekes, Vandna Shah, Patrycja Gazinska, Shalaka Joshi, Bhavna Sidhu, Cheryl Gillett, Sarah Pinder, Fabio Vanoli, Maria Jasin, Markus Mayrhofer, Anders Isaksson, Maggie C.U. Cheang, Hasan Mirza, Jessica Frankum, Christopher J. Lord, Alan Ashworth, Shaveta Vinayak, James M. Ford, Melinda L. Telli, Anita Grigoriadis, Andrew N.J. Tutt
Journal: Cancer Discovery
Cancer Discov (2015) 5 (5): 488–505.
https://doi.org/10.1158/2159-8290.CD-14-1092
Published: 03 May 2015
View article titled, Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers
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Includes: Supplementary data
Journal Articles

An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor

Nirupa Murugaesu, Marjan Iravani, Antoinette van Weverwijk, Aleksandar Ivetic, Damian A. Johnson, Aristotelis Antonopoulos, Antony Fearns, Mariam Jamal-Hanjani, David Sims, Kerry Fenwick, Costas Mitsopoulos, Qiong Gao, Nick Orr, Marketa Zvelebil, Stuart M. Haslam, Anne Dell, Helen Yarwood, Christopher J. Lord, Alan Ashworth, Clare M. Isacke
Journal: Cancer Discovery
Cancer Discov (2014) 4 (3): 304–317.
https://doi.org/10.1158/2159-8290.CD-13-0287
Published: 03 March 2014
View article titled, An <em>In Vivo</em> Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor
Open the PDF for An <em>In Vivo</em> Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor in another window
Includes: Multimedia, Supplementary data
Journal Articles

Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

Lynn Bjerke, Alan Mackay, Meera Nandhabalan, Anna Burford, Alexa Jury, Sergey Popov, Dorine A. Bax, Diana Carvalho, Kathryn R. Taylor, Maria Vinci, Ilirjana Bajrami, Imelda M. McGonnell, Christopher J. Lord, Rui M. Reis, Darren Hargrave, Alan Ashworth, Paul Workman, Chris Jones
Journal: Cancer Discovery
Cancer Discov (2013) 3 (5): 512–519.
https://doi.org/10.1158/2159-8290.CD-12-0426
Published: 08 May 2013
View article titled, Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
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Includes: Supplementary data
Journal Articles

The Promise of Combining Inhibition of PI3K and PARP as Cancer Therapy

Farah L. Rehman, Christopher J. Lord, Alan Ashworth
Journal: Cancer Discovery
Cancer Discov (2012) 2 (11): 982–984.
https://doi.org/10.1158/2159-8290.CD-12-0433
Published: 11 November 2012
View article titled, The Promise of Combining Inhibition of PI3K and PARP as Cancer Therapy
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Journal Articles

Functional Viability Profiles of Breast Cancer

Rachel Brough, Jessica R. Frankum, David Sims, Alan Mackay, Ana M. Mendes-Pereira, Ilirjana Bajrami, Sara Costa-Cabral, Rumana Rafiq, Amar S. Ahmad, Maria Antonietta Cerone, Rachael Natrajan, Rachel Sharpe, Kai-Keen Shiu, Daniel Wetterskog, Konstantine J. Dedes, Maryou B. Lambros, Teeara Rawjee, Spiros Linardopoulos, Jorge S. Reis-Filho, Nicholas C. Turner, Christopher J. Lord, Alan Ashworth
Journal: Cancer Discovery
Cancer Discov (2011) 1 (3): 260–273.
https://doi.org/10.1158/2159-8290.CD-11-0107
Published: 15 August 2011
View article titled, Functional Viability Profiles of Breast Cancer
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Includes: Supplementary data