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Benjamin G. Neel
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Journal Articles

Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy

Takamitsu Hattori, Lorenzo Maso, Kiyomi Y. Araki, Akiko Koide, James Hayman, Padma Akkapeddi, Injin Bang, Benjamin G. Neel, Shohei Koide
Journal: Cancer Discovery
Cancer Discov (2023) 13 (1): 132–145.
https://doi.org/10.1158/2159-8290.CD-22-1074
Published: 09 January 2023
View article titled, Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy
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Includes: Supplementary data
Journal Articles

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

Chewei Anderson Chang, Jayu Jen, Shaowen Jiang, Azin Sayad, Arvind Singh Mer, Kevin R. Brown, Allison M.L. Nixon, Avantika Dhabaria, Kwan Ho Tang, David Venet, Christos Sotiriou, Jiehui Deng, Kwok-kin Wong, Sylvia Adams, Peter Meyn, Adriana Heguy, Jane A. Skok, Aristotelis Tsirigos, Beatrix Ueberheide, Jason Moffat, Abhyudai Singh, Benjamin Haibe-Kains, Alireza Khodadadi-Jamayran, Benjamin G. Neel
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1022–1045.
https://doi.org/10.1158/2159-8290.CD-20-1265
Published: 01 April 2022
View article titled, Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2<sup>+</sup> Breast Cancer
Open the PDF for Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2<sup>+</sup> Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

Kwan Ho Tang, Shuai Li, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A. Zebala, Dean Y. Maeda, James G. Christensen, Peter Olson, Argus Athanas, Cynthia A. Loomis, Aristotelis Tsirigos, Kwok-Kin Wong, Benjamin G. Neel
Journal: Cancer Discovery
Cancer Discov (2022) 12 (1): 47–61.
https://doi.org/10.1158/2159-8290.CD-21-0369
Published: 01 January 2022
View article titled, Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC
Open the PDF for Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC in another window
Includes: Supplementary data
Journal Articles

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

Shuang Zhang, Sonia Iyer, Hao Ran, Igor Dolgalev, Shengqing Gu, Wei Wei, Connor J.R. Foster, Cynthia A. Loomis, Narciso Olvera, Fanny Dao, Douglas A. Levine, Robert A. Weinberg, Benjamin G. Neel
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (2): 362–383.
https://doi.org/10.1158/2159-8290.CD-20-0455
Published: 02 February 2021
View article titled, Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer
Open the PDF for Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy

Sonia Iyer, Shuang Zhang, Simge Yucel, Heiko Horn, Sean G. Smith, Ferenc Reinhardt, Esmee Hoefsmit, Bimarzhan Assatova, Julia Casado, Marie-Charlotte Meinsohn, M. Inmaculada Barrasa, George W. Bell, Fernando Pérez-Villatoro, Kaisa Huhtinen, Johanna Hynninen, Jaana Oikkonen, Pamoda M. Galhenage, Shailja Pathania, Paula T. Hammond, Benjamin G. Neel, Anniina Farkkila, David Pépin, Robert A. Weinberg
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (2): 384–407.
https://doi.org/10.1158/2159-8290.CD-20-0818
Published: 02 February 2021
View article titled, Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy
Open the PDF for Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy in another window
Includes: Supplementary data
Journal Articles

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

Carmine Fedele, Hao Ran, Brian Diskin, Wei Wei, Jayu Jen, Mitchell J. Geer, Kiyomi Araki, Ugur Ozerdem, Diane M. Simeone, George Miller, Benjamin G. Neel, Kwan Ho Tang
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (10): 1237–1249.
https://doi.org/10.1158/2159-8290.CD-18-0444
Published: 02 October 2018
View article titled, SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models
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Includes: Supplementary data
Journal Articles

Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells

Richard Marcotte, Kevin R. Brown, Fernando Suarez, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice L.Y. Koh, Dewald van Dyk, Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat
Journal: Cancer Discovery
Cancer Discov (2012) 2 (2): 172–189.
https://doi.org/10.1158/2159-8290.CD-11-0224
Published: 12 February 2012
View article titled, Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Open the PDF for Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells in another window
Includes: Supplementary data