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Ben Z. Stanger
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Journal Articles

Intrinsic properties of the lymph node render it immunologically susceptible to metastasis

Open Access
Benjamin M. Kahn, Raymond W.S. Ng, Il-Kyu Kim, Cody Eskandarian, Chelsey O. Chen, Bing Huang, Alfredo Lucas, Lequn Li, Ivan Maillard, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2025)
https://doi.org/10.1158/2159-8290.CD-24-1847
Published: 24 April 2025
View articletitled, Intrinsic properties of the lymph node render it immunologically susceptible to metastasis
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Includes: Supplementary data
Journal Articles

T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC

Open Access
Margo I. Orlen, William P. Vostrejs, Rina Sor, Jayne C. McDevitt, Samantha B. Kemp, Il-Kyu Kim, Adam B. Kramer, Nataliya Tovbis Shifrin, Nune Markosyan, Cynthia Clendenin, Mallika Singh, Elsa Quintana, Marie Menard, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2025)
https://doi.org/10.1158/2159-8290.CD-24-1475
Published: 07 March 2025
View articletitled, T-cell dependency of tumor regressions and complete responses with RAS(ON) multi-selective inhibition in preclinical models of PDAC
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Includes: Supplementary data
Journal Articles

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Open Access
Julien Dilly, Megan T. Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D. Parent, Connor J. Hennessey, Alexander C. Jordan, Micaela Morgado, Shatavisha Dasgupta, Giselle A. Uribe, Annan Yang, Kevin S. Kapner, Felix P. Hambitzer, Li Qiang, Hanrong Feng, Jacob Geisberg, Junning Wang, Kyle E. Evans, Hengyu Lyu, Aislyn Schalck, Ningping Feng, Anastasia M. Lopez, Christopher A. Bristow, Michael P. Kim, Kimal I. Rajapakshe, Vahid Bahrambeigi, Jennifer A. Roth, Kavita Garg, Paola A. Guerrero, Ben Z. Stanger, Simona Cristea, Scott W. Lowe, Timour Baslan, Eliezer M. Van Allen, Joseph D. Mancias, Emily Chan, Abraham Anderson, Yuliya V. Katlinskaya, Alex K. Shalek, David S. Hong, Shubham Pant, Jill Hallin, Kenna Anderes, Peter Olson, Timothy P. Heffernan, Seema Chugh, James G. Christensen, Anirban Maitra, Brian M. Wolpin, Srivatsan Raghavan, Jonathan A. Nowak, Peter S. Winter, Stephanie K. Dougan, Andrew J. Aguirre
Journal: Cancer Discovery
Cancer Discov (2024) 14 (11): 2135–2161.
https://doi.org/10.1158/2159-8290.CD-24-0177
Published: 01 November 2024
View articletitled, Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Available to Purchase
Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Samara Singh, Siddharth Mehra, Vanessa T. Garrido, Xinyu Guo, Luis A. Nivelo, Despina S. Kolonias, Shannon J. Saigh, Eric Wieder, Christine I. Rafie, Austin R. Dosch, Zhiqun Zhou, Oliver Umland, Haleh Amirian, Ifeanyichukwu C. Ogobuiro, Jian Zhang, Yuguang Ban, Carina Shiau, Nagaraj S. Nagathihalli, Elizabeth A. Montgomery, William L. Hwang, Roberta Brambilla, Krishna Komanduri, Alejandro V. Villarino, Eneda Toska, Ben Z. Stanger, Dmitry I. Gabrilovich, Nipun B. Merchant, Jashodeep Datta
Journal: Cancer Discovery
Cancer Discov (2023) 13 (6): 1428–1453.
https://doi.org/10.1158/2159-8290.CD-22-1046
Published: 02 June 2023
View articletitled, Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Open Access
Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2023) 13 (2): 298–311.
https://doi.org/10.1158/2159-8290.CD-22-1066
Published: 06 February 2023
View articletitled, Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs

Available to Purchase
Fangxue Yan, Jinyang Li, Jelena Milosevic, Ricardo Petroni, Suying Liu, Zhennan Shi, Salina Yuan, Janice M. Reynaga, Yuwei Qi, Joshua Rico, Sixiang Yu, Yiman Liu, Susumu Rokudai, Neil Palmisiano, Sara E. Meyer, Pamela J. Sung, Liling Wan, Fei Lan, Benjamin A. Garcia, Ben Z. Stanger, David B. Sykes, M. Andrés Blanco
Journal: Cancer Discovery
Cancer Discov (2022) 12 (3): 792–811.
https://doi.org/10.1158/2159-8290.CD-20-1459
Published: 01 March 2022
View articletitled, KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs
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Includes: Supplementary data
Journal Articles

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma

Open Access
Ravikanth Maddipati, Robert J. Norgard, Timour Baslan, Komal S. Rathi, Amy Zhang, Asal Saeid, Taku Higashihara, Feng Wu, Angad Kumar, Valli Annamalai, Saurav Bhattacharya, Pichai Raman, Christian A. Adkisson, Jason R. Pitarresi, Maximilian D. Wengyn, Taiji Yamazoe, Jinyang Li, David Balli, Michael J. LaRiviere, Tuong-Vi C. Ngo, Ian W. Folkert, Ian D. Millstein, Jonathan Bermeo, Erica L. Carpenter, John C. McAuliffe, Maja H. Oktay, Rolf A. Brekken, Scott W. Lowe, Christine A. Iacobuzio-Donahue, Faiyaz Notta, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2022) 12 (2): 542–561.
https://doi.org/10.1158/2159-8290.CD-20-1826
Published: 01 February 2022
View articletitled, MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma
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Includes: Supplementary data
Journal Articles

PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability

Free
Jason R. Pitarresi, Robert J. Norgard, Anna M. Chiarella, Kensuke Suzuki, Basil Bakir, Varun Sahu, Jinyang Li, Jun Zhao, Benoît Marchand, Maximilian D. Wengyn, Antony Hsieh, Il-Kyu Kim, Amy Zhang, Karine Sellin, Vivian Lee, Shigetsugu Takano, Yoji Miyahara, Masayuki Ohtsuka, Anirban Maitra, Faiyaz Notta, Richard Kremer, Ben Z. Stanger, Anil K. Rustgi
Journal: Cancer Discovery
Cancer Discov (2021) 11 (7): 1774–1791.
https://doi.org/10.1158/2159-8290.CD-20-1098
Published: 01 July 2021
View articletitled, PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability
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Includes: Supplementary data
Journal Articles

Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer

Free
Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Yu H. Sun, Il-Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan V. Bhanu, Benjamin A. Garcia, Robert H. Vonderheide, Andrés Blanco, Ben Z. Stanger
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (3): 736–753.
https://doi.org/10.1158/2159-8290.CD-20-0519
Published: 02 March 2021
View articletitled, Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression

Free
Salina Yuan, Ramakrishnan Natesan, Francisco J. Sanchez-Rivera, Jinyang Li, Natarajan V. Bhanu, Taiji Yamazoe, Jeffrey H. Lin, Allyson J. Merrell, Yogev Sela, Stacy K. Thomas, Yanqing Jiang, Jacqueline B. Plesset, Emma M. Miller, Junwei Shi, Benjamin A. Garcia, Scott W. Lowe, Irfan A. Asangani, Ben Z. Stanger
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (6): 854–871.
https://doi.org/10.1158/2159-8290.CD-19-1299
Published: 01 June 2020
View articletitled, Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression
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Includes: Supplementary data
Journal Articles

Cellular Plasticity in Cancer

Free
Salina Yuan, Robert J. Norgard, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2019) 9 (7): 837–851.
https://doi.org/10.1158/2159-8290.CD-19-0015
Published: 01 July 2019
View articletitled, Cellular Plasticity in Cancer
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Journal Articles

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis

Free
Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney L. Campbell, Robert J. Norgard, Kollin C. Schultz, Simone Sidoli, Joshua L.D. Parris, Hayley C. Affronti, Sharanya Sivanand, Shaun Egolf, Yogev Sela, Marco Trizzino, Alessandro Gardini, Benjamin A. Garcia, Nathaniel W. Snyder, Ben Z. Stanger, Kathryn E. Wellen
Journal: Cancer Discovery
Cancer Discov (2019) 9 (3): 416–435.
https://doi.org/10.1158/2159-8290.CD-18-0567
Published: 01 March 2019
View articletitled, Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
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Includes: Supplementary data
Journal Articles

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality

Free
Ravikanth Maddipati, Ben Z. Stanger
Journal: Cancer Discovery
Cancer Discov (2015) 5 (10): 1086–1097.
https://doi.org/10.1158/2159-8290.CD-15-0120
Published: 30 September 2015
View articletitled, Pancreatic Cancer Metastases Harbor Evidence of Polyclonality
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Includes: Supplementary data