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Alice T. Shaw
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Journal Articles

Response and Resistance to RAS Inhibition in Cancer

Available to Purchase
Richard Y. Ebright, Julien Dilly, Alice T. Shaw, Andrew J. Aguirre
Journal: Cancer Discovery
Cancer Discov OF1–OF25.
https://doi.org/10.1158/2159-8290.CD-25-0349
Published: 28 April 2025
View articletitled, Response and Resistance to RAS Inhibition in Cancer
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Includes: Supplementary data
Journal Articles

Strengthening Asian/Asian American, Native Hawaiian, and Pacific Islander Leadership in Cancer Research

Free
Lawrence W. Wu, Ryan H. Moy, the AACR AANHPI Task Force, Nina Bhardwaj, Kathleen Cho, Gen-Sheng Feng, Edward S. Kim, Ming Lei, Edison T. Liu, Anirban Maitra, Motomi Mori, Irene O.L. Ng, Masanobu Oshima, William Pao, Ben Ho Park, Suresh Ramalingam, Sun Young Rha, Sandra W. Ryeom, Alice T. Shaw, Lillian L. Siu, Anil K. Suri, Daniel S. Tan, Kenneth K. Tanabe, Naoto T. Ueno, Sunil Verma, Kwok-Kin Wong, Catherine J. Wu, Hong Wu, James Chih-Hsin Yang
Journal: Cancer Discovery
Cancer Discov (2025) 15 (2): 267–270.
https://doi.org/10.1158/2159-8290.CD-24-1618
Published: 07 February 2025
View articletitled, Strengthening Asian/Asian American, Native Hawaiian, and Pacific Islander Leadership in Cancer Research
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Journal Articles

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Free
Anna F. Farago, Beow Y. Yeap, Marcello Stanzione, Yin P. Hung, Rebecca S. Heist, J. Paul Marcoux, Jun Zhong, Deepa Rangachari, David A. Barbie, Sarah Phat, David T. Myers, Robert Morris, Marina Kem, Taronish D. Dubash, Elizabeth A. Kennedy, Subba R. Digumarthy, Lecia V. Sequist, Aaron N. Hata, Shyamala Maheswaran, Daniel A. Haber, Michael S. Lawrence, Alice T. Shaw, Mari Mino-Kenudson, Nicholas J. Dyson, Benjamin J. Drapkin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2019) 9 (10): 1372–1387.
https://doi.org/10.1158/2159-8290.CD-19-0582
Published: 01 October 2019
View articletitled, Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion

Free
Zofia Piotrowska, Hideko Isozaki, Jochen K. Lennerz, Justin F. Gainor, Inga T. Lennes, Viola W. Zhu, Nicolas Marcoux, Mandeep K. Banwait, Subba R. Digumarthy, Wenjia Su, Satoshi Yoda, Amanda K. Riley, Varuna Nangia, Jessica J. Lin, Rebecca J. Nagy, Richard B. Lanman, Dora Dias-Santagata, Mari Mino-Kenudson, A. John Iafrate, Rebecca S. Heist, Alice T. Shaw, Erica K. Evans, Corinne Clifford, Sai-Hong I. Ou, Beni Wolf, Aaron N. Hata, Lecia V. Sequist
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (12): 1529–1539.
https://doi.org/10.1158/2159-8290.CD-18-1022
Published: 03 December 2018
View articletitled, Landscape of Acquired Resistance to Osimertinib in EGFR-Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired RET Fusion
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Includes: Supplementary data
Journal Articles

Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations

Free
Alexander Drilon, Sai-Hong Ignatius Ou, Byoung Chul Cho, Dong-Wan Kim, Jeeyun Lee, Jessica J. Lin, Viola W. Zhu, Myung-Ju Ahn, D. Ross Camidge, Judy Nguyen, Dayong Zhai, Wei Deng, Zhongdong Huang, Evan Rogers, Juliet Liu, Jeff Whitten, John K. Lim, Shanna Stopatschinskaja, David M. Hyman, Robert C. Doebele, J. Jean Cui, Alice T. Shaw
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (10): 1227–1236.
https://doi.org/10.1158/2159-8290.CD-18-0484
Published: 02 October 2018
View articletitled, Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations
Open the PDF for Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations in another window
Includes: Supplementary data
Journal Articles

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma

Free
Ferdinandos Skoulidis, Michael E. Goldberg, Danielle M. Greenawalt, Matthew D. Hellmann, Mark M. Awad, Justin F. Gainor, Alexa B. Schrock, Ryan J. Hartmaier, Sally E. Trabucco, Laurie Gay, Siraj M. Ali, Julia A. Elvin, Gaurav Singal, Jeffrey S. Ross, David Fabrizio, Peter M. Szabo, Han Chang, Ariella Sasson, Sujaya Srinivasan, Stefan Kirov, Joseph Szustakowski, Patrik Vitazka, Robin Edwards, Jose A. Bufill, Neelesh Sharma, Sai-Hong I. Ou, Nir Peled, David R. Spigel, Hira Rizvi, Elizabeth Jimenez Aguilar, Brett W. Carter, Jeremy Erasmus, Darragh F. Halpenny, Andrew J. Plodkowski, Niamh M. Long, Mizuki Nishino, Warren L. Denning, Ana Galan-Cobo, Haifa Hamdi, Taghreed Hirz, Pan Tong, Jing Wang, Jaime Rodriguez-Canales, Pamela A. Villalobos, Edwin R. Parra, Neda Kalhor, Lynette M. Sholl, Jennifer L. Sauter, Achim A. Jungbluth, Mari Mino-Kenudson, Roxana Azimi, Yasir Y. Elamin, Jianjun Zhang, Giulia C. Leonardi, Fei Jiang, Kwok-Kin Wong, J. Jack Lee, Vassiliki A. Papadimitrakopoulou, Ignacio I. Wistuba, Vincent A. Miller, Garrett M. Frampton, Jedd D. Wolchok, Alice T. Shaw, Pasi A. Jänne, Philip J. Stephens, Charles M. Rudin, William J. Geese, Lee A. Albacker, John V. Heymach
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (7): 822–835.
https://doi.org/10.1158/2159-8290.CD-18-0099
Published: 01 July 2018
View articletitled, STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer

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Satoshi Yoda, Jessica J. Lin, Michael S. Lawrence, Benjamin J. Burke, Luc Friboulet, Adam Langenbucher, Leila Dardaei, Kylie Prutisto-Chang, Ibiayi Dagogo-Jack, Sergei Timofeevski, Harper Hubbeling, Justin F. Gainor, Lorin A. Ferris, Amanda K. Riley, Krystina E. Kattermann, Daria Timonina, Rebecca S. Heist, A. John Iafrate, Cyril H. Benes, Jochen K. Lennerz, Mari Mino-Kenudson, Jeffrey A. Engelman, Ted W. Johnson, Aaron N. Hata, Alice T. Shaw
Journal: Cancer Discovery
Cancer Discov (2018) 8 (6): 714–729.
https://doi.org/10.1158/2159-8290.CD-17-1256
Published: 31 May 2018
View articletitled, Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer
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Includes: Supplementary data
Journal Articles

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

Free
Benjamin J. Drapkin, Julie George, Camilla L. Christensen, Mari Mino-Kenudson, Ruben Dries, Tilak Sundaresan, Sarah Phat, David T. Myers, Jun Zhong, Peter Igo, Mehlika H. Hazar-Rethinam, Joseph A. Licausi, Maria Gomez-Caraballo, Marina Kem, Kandarp N. Jani, Roxana Azimi, Nima Abedpour, Roopika Menon, Sotirios Lakis, Rebecca S. Heist, Reinhard Büttner, Stefan Haas, Lecia V. Sequist, Alice T. Shaw, Kwok-Kin Wong, Aaron N. Hata, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber, Martin Peifer, Nicholas Dyson, Roman K. Thomas, Anna F. Farago
Journal: Cancer Discovery
Cancer Discov (2018) 8 (5): 600–615.
https://doi.org/10.1158/2159-8290.CD-17-0935
Published: 30 April 2018
View articletitled, Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
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Includes: Supplementary data
Journal Articles

Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)

Free
Alexander Drilon, Salvatore Siena, Sai-Hong Ignatius Ou, Manish Patel, Myung Ju Ahn, Jeeyun Lee, Todd M. Bauer, Anna F. Farago, Jennifer J. Wheler, Stephen V. Liu, Robert Doebele, Laura Giannetta, Giulio Cerea, Giovanna Marrapese, Michele Schirru, Alessio Amatu, Katia Bencardino, Laura Palmeri, Andrea Sartore-Bianchi, Angelo Vanzulli, Sara Cresta, Silvia Damian, Matteo Duca, Elena Ardini, Gang Li, Jason Christiansen, Karey Kowalski, Ann D. Johnson, Rupal Patel, David Luo, Edna Chow-Maneval, Zachary Hornby, Pratik S. Multani, Alice T. Shaw, Filippo G. De Braud
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (4): 400–409.
https://doi.org/10.1158/2159-8290.CD-16-1237
Published: 02 April 2017
View articletitled, Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)
Open the PDF for Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1) in another window
Includes: Supplementary data
Journal Articles

Targeting ALK: Precision Medicine Takes on Drug Resistance

Free
Jessica J. Lin, Gregory J. Riely, Alice T. Shaw
Journal: Cancer Discovery
Cancer Discov (2017) 7 (2): 137–155.
https://doi.org/10.1158/2159-8290.CD-16-1123
Published: 05 February 2017
View articletitled, Targeting ALK: Precision Medicine Takes on Drug Resistance
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Journal Articles

Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

Free
Justin F. Gainor, Leila Dardaei, Satoshi Yoda, Luc Friboulet, Ignaty Leshchiner, Ryohei Katayama, Ibiayi Dagogo-Jack, Shirish Gadgeel, Katherine Schultz, Manrose Singh, Emily Chin, Melissa Parks, Dana Lee, Richard H. DiCecca, Elizabeth Lockerman, Tiffany Huynh, Jennifer Logan, Lauren L. Ritterhouse, Long P. Le, Ashok Muniappan, Subba Digumarthy, Colleen Channick, Colleen Keyes, Gad Getz, Dora Dias-Santagata, Rebecca S. Heist, Jochen Lennerz, Lecia V. Sequist, Cyril H. Benes, A. John Iafrate, Mari Mino-Kenudson, Jeffrey A. Engelman, Alice T. Shaw
Journal: Cancer Discovery
Cancer Discov (2016) 6 (10): 1118–1133.
https://doi.org/10.1158/2159-8290.CD-16-0596
Published: 02 October 2016
View articletitled, Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer
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Includes: Supplementary data
Journal Articles

Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

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Zofia Piotrowska, Matthew J. Niederst, Chris A. Karlovich, Heather A. Wakelee, Joel W. Neal, Mari Mino-Kenudson, Linnea Fulton, Aaron N. Hata, Elizabeth L. Lockerman, Anuj Kalsy, Subba Digumarthy, Alona Muzikansky, Mitch Raponi, Angel R. Garcia, Hillary E. Mulvey, Melissa K. Parks, Richard H. DiCecca, Dora Dias-Santagata, A. John Iafrate, Alice T. Shaw, Andrew R. Allen, Jeffrey A. Engelman, Lecia V. Sequist
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (7): 713–722.
https://doi.org/10.1158/2159-8290.CD-15-0399
Published: 06 July 2015
View articletitled, Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor
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Includes: Supplementary data
Journal Articles

The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer

Free
Luc Friboulet, Nanxin Li, Ryohei Katayama, Christian C. Lee, Justin F. Gainor, Adam S. Crystal, Pierre-Yves Michellys, Mark M. Awad, Noriko Yanagitani, Sungjoon Kim, AnneMarie C. Pferdekamper, Jie Li, Shailaja Kasibhatla, Frank Sun, Xiuying Sun, Su Hua, Peter McNamara, Sidra Mahmood, Elizabeth L. Lockerman, Naoya Fujita, Makoto Nishio, Jennifer L. Harris, Alice T. Shaw, Jeffrey A. Engelman
Journal: Cancer Discovery
Cancer Discov (2014) 4 (6): 662–673.
https://doi.org/10.1158/2159-8290.CD-13-0846
Published: 01 June 2014
View articletitled, The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

The New Kid on the Block: RET in Lung Cancer

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Justin F. Gainor, Alice T. Shaw
Journal: Cancer Discovery
Cancer Discov (2013) 3 (6): 604–606.
https://doi.org/10.1158/2159-8290.CD-13-0174
Published: 06 June 2013
View articletitled, The New Kid on the Block: RET in Lung Cancer
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Journal Articles

Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer

Free
Jim Sang, Jaime Acquaviva, Julie C. Friedland, Donald L. Smith, Manuel Sequeira, Chaohua Zhang, Qin Jiang, Liquan Xue, Christine M. Lovly, John-Paul Jimenez, Alice T. Shaw, Robert C. Doebele, Suqin He, Richard C. Bates, D. Ross Camidge, Stephan W. Morris, Iman El-Hariry, David A. Proia
Journal: Cancer Discovery
Cancer Discov (2013) 3 (4): 430–443.
https://doi.org/10.1158/2159-8290.CD-12-0440
Published: 10 April 2013
View articletitled, Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
Open the PDF for Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data