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Agnes Viale
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Journal Articles

Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition

James J. Harding, Maeve A. Lowery, Alan H. Shih, Juan M. Schvartzman, Shengqi Hou, Christopher Famulare, Minal Patel, Mikhail Roshal, Richard K. Do, Ahmet Zehir, Daoqi You, S. Duygu Selcuklu, Agnes Viale, Martin S. Tallman, David M. Hyman, Ed Reznik, Lydia W.S. Finley, Elli Papaemmanuil, Alessandra Tosolini, Mark G. Frattini, Kyle J. MacBeth, Guowen Liu, Bin Fan, Sung Choe, Bin Wu, Yelena Y. Janjigian, Ingo K. Mellinghoff, Luis A. Diaz, Ross L. Levine, Ghassan K. Abou-Alfa, Eytan M. Stein, Andrew M. Intlekofer
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (12): 1540–1547.
https://doi.org/10.1158/2159-8290.CD-18-0877
Published: 03 December 2018
View article titled, Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition
Open the PDF for Isoform Switching as a Mechanism of Acquired Resistance to Mutant Isocitrate Dehydrogenase Inhibition in another window
Includes: Supplementary data
Journal Articles

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma

Christian Grommes, Alessandro Pastore, Nicolaos Palaskas, Sarah S. Tang, Carl Campos, Derrek Schartz, Paolo Codega, Donna Nichol, Owen Clark, Wan-Ying Hsieh, Dan Rohle, Marc Rosenblum, Agnes Viale, Viviane S. Tabar, Cameron W. Brennan, Igor T. Gavrilovic, Thomas J. Kaley, Craig P. Nolan, Antonio Omuro, Elena Pentsova, Alissa A. Thomas, Elina Tsyvkin, Ariela Noy, M. Lia Palomba, Paul Hamlin, Craig S. Sauter, Craig H. Moskowitz, Julia Wolfe, Ahmet Dogan, Minhee Won, Jon Glass, Scott Peak, Enrico C. Lallana, Vaios Hatzoglou, Anne S. Reiner, Philip H. Gutin, Jason T. Huse, Katherine S. Panageas, Thomas G. Graeber, Nikolaus Schultz, Lisa M. DeAngelis, Ingo K. Mellinghoff
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2017) 7 (9): 1018–1029.
https://doi.org/10.1158/2159-8290.CD-17-0613
Published: 31 August 2017
View article titled, Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma
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Includes: Supplementary data
Journal Articles

NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition

Maria E.R. Garcia-Rendueles, Julio C. Ricarte-Filho, Brian R. Untch, Iňigo Landa, Jeffrey A. Knauf, Francesca Voza, Vicki E. Smith, Ian Ganly, Barry S. Taylor, Yogindra Persaud, Gisele Oler, Yuqiang Fang, Suresh C. Jhanwar, Agnes Viale, Adriana Heguy, Kety H. Huberman, Filippo Giancotti, Ronald Ghossein, James A. Fagin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (11): 1178–1193.
https://doi.org/10.1158/2159-8290.CD-15-0330
Published: 01 November 2015
View article titled, <em>NF2</em> Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
Open the PDF for <em>NF2</em> Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

Hikmat Al-Ahmadie, Gopa Iyer, Marcel Hohl, Saurabh Asthana, Akiko Inagaki, Nikolaus Schultz, Aphrothiti J. Hanrahan, Sasinya N. Scott, A. Rose Brannon, Gregory C. McDermott, Mono Pirun, Irina Ostrovnaya, Philip Kim, Nicholas D. Socci, Agnes Viale, Gary K. Schwartz, Victor Reuter, Bernard H. Bochner, Jonathan E. Rosenberg, Dean F. Bajorin, Michael F. Berger, John H.J. Petrini, David B. Solit, Barry S. Taylor
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2014) 4 (9): 1014–1021.
https://doi.org/10.1158/2159-8290.CD-14-0380
Published: 01 September 2014
View article titled, Synthetic Lethality in ATM-Deficient <em>RAD50</em>-Mutant Tumors Underlies Outlier Response to Cancer Therapy
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Includes: Supplementary data
Journal Articles

Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies

Omar Abdel-Wahab, Virginia M. Klimek, Alisa A. Gaskell, Agnes Viale, Donavan Cheng, Eunhee Kim, Raajit Rampal, Mark Bluth, James J. Harding, Margaret K. Callahan, Taha Merghoub, Michael F. Berger, David B. Solit, Neal Rosen, Ross L. Levine, Paul B. Chapman
Journal: Cancer Discovery
Cancer Discov (2014) 4 (5): 538–545.
https://doi.org/10.1158/2159-8290.CD-13-1038
Published: 01 May 2014
View article titled, Efficacy of Intermittent Combined RAF and MEK Inhibition in a Patient with Concurrent BRAF- and NRAS-Mutant Malignancies
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Includes: Supplementary data
Journal Articles

Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas

Cristina Montero-Conde, Sergio Ruiz-Llorente, Jose M. Dominguez, Jeffrey A. Knauf, Agnes Viale, Eric J. Sherman, Mabel Ryder, Ronald A. Ghossein, Neal Rosen, James A. Fagin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2013) 3 (5): 520–533.
https://doi.org/10.1158/2159-8290.CD-12-0531
Published: 08 May 2013
View article titled, Relief of Feedback Inhibition of <em>HER3</em> Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in <em>BRAF</em>-Mutant Thyroid Carcinomas
Open the PDF for Relief of Feedback Inhibition of <em>HER3</em> Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in <em>BRAF</em>-Mutant Thyroid Carcinomas in another window
Includes: Supplementary data