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Adriana Heguy
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Journal Articles

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

Chewei Anderson Chang, Jayu Jen, Shaowen Jiang, Azin Sayad, Arvind Singh Mer, Kevin R. Brown, Allison M.L. Nixon, Avantika Dhabaria, Kwan Ho Tang, David Venet, Christos Sotiriou, Jiehui Deng, Kwok-kin Wong, Sylvia Adams, Peter Meyn, Adriana Heguy, Jane A. Skok, Aristotelis Tsirigos, Beatrix Ueberheide, Jason Moffat, Abhyudai Singh, Benjamin Haibe-Kains, Alireza Khodadadi-Jamayran, Benjamin G. Neel
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1022–1045.
https://doi.org/10.1158/2159-8290.CD-20-1265
Published: 01 April 2022
View article titled, Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2<sup>+</sup> Breast Cancer
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Includes: Supplementary data
Journal Articles

Lower Airway Dysbiosis Affects Lung Cancer Progression

Jun-Chieh J. Tsay, Benjamin G. Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T. Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L. Bessich, Robert L. Smith, Harald Sauthoff, Kevin Felner, Ray Pillai, Anastasia-Maria Zavitsanou, Sergei B. Koralov, Valeria Mezzano, Cynthia A. Loomis, Andre L. Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N. Rom, Daniel H. Sterman, Harvey I. Pass, Jose C. Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos, Leopoldo N. Segal
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (2): 293–307.
https://doi.org/10.1158/2159-8290.CD-20-0263
Published: 02 February 2021
View article titled, Lower Airway Dysbiosis Affects Lung Cancer Progression
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Includes: Supplementary data
Journal Articles

Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia

Yalu Zhou, Cuijuan Han, Eric Wang, Adam H. Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T. Gutierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna Kuchmiy, Limin Sun, George Yacu, Szymon K. Filip, Qi Jin, Yoh-Hei Takahashi, David R. Amici, Emily J. Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawati Kandela, Yuliya Politanska, Hiam Abdala-Valencia, Marc L. Mendillo, Ping Zhu, Bruno Palhais, Pieter Van Vlierberghe, Tom Taghon, Iannis Aifantis, Young Ah Goo, Ernesto Guccione, Adriana Heguy, Aristotelis Tsirigos, Keng Boon Wee, Rama K. Mishra, Francoise Pflumio, Benedetta Accordi, Giuseppe Basso, Panagiotis Ntziachristos
Journal: Cancer Discovery
Cancer Discov (2020) 10 (9): 1388–1409.
https://doi.org/10.1158/2159-8290.CD-19-1436
Published: 01 September 2020
View article titled, Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia
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Includes: Supplementary data
Journal Articles

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Eli L. Diamond, Benjamin H. Durham, Julien Haroche, Zhan Yao, Jing Ma, Sameer A. Parikh, Zhaoming Wang, John Choi, Eunhee Kim, Fleur Cohen-Aubart, Stanley Chun-Wei Lee, Yijun Gao, Jean-Baptiste Micol, Patrick Campbell, Michael P. Walsh, Brooke Sylvester, Igor Dolgalev, Olga Aminova, Adriana Heguy, Paul Zappile, Joy Nakitandwe, Chezi Ganzel, James D. Dalton, David W. Ellison, Juvianee Estrada-Veras, Mario Lacouture, William A. Gahl, Philip J. Stephens, Vincent A. Miller, Jeffrey S. Ross, Siraj M. Ali, Samuel R. Briggs, Omotayo Fasan, Jared Block, Sebastien Héritier, Jean Donadieu, David B. Solit, David M. Hyman, José Baselga, Filip Janku, Barry S. Taylor, Christopher Y. Park, Zahir Amoura, Ahmet Dogan, Jean-Francois Emile, Neal Rosen, Tanja A. Gruber, Omar Abdel-Wahab
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2016) 6 (2): 154–165.
https://doi.org/10.1158/2159-8290.CD-15-0913
Published: 04 February 2016
View article titled, Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
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Includes: Supplementary data
Journal Articles

NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition

Maria E.R. Garcia-Rendueles, Julio C. Ricarte-Filho, Brian R. Untch, Iňigo Landa, Jeffrey A. Knauf, Francesca Voza, Vicki E. Smith, Ian Ganly, Barry S. Taylor, Yogindra Persaud, Gisele Oler, Yuqiang Fang, Suresh C. Jhanwar, Agnes Viale, Adriana Heguy, Kety H. Huberman, Filippo Giancotti, Ronald Ghossein, James A. Fagin
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2015) 5 (11): 1178–1193.
https://doi.org/10.1158/2159-8290.CD-15-0330
Published: 01 November 2015
View article titled, <em>NF2</em> Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
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Includes: Supplementary data
Journal Articles

RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas

Georgia Konstantinidou, Giorgio Ramadori, Francesca Torti, Kim Kangasniemi, Rachel E. Ramirez, Yiran Cai, Carmen Behrens, Michael T. Dellinger, Rolf A. Brekken, Ignacio I. Wistuba, Adriana Heguy, Julie Teruya-Feldstein, Pier Paolo Scaglioni
Journal: Cancer Discovery
Cancer Discov (2013) 3 (4): 444–457.
https://doi.org/10.1158/2159-8290.CD-12-0388
Published: 10 April 2013
View article titled, RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas
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Includes: Supplementary data
Journal Articles

Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors

Igor Vivanco, H. Ian Robins, Daniel Rohle, Carl Campos, Christian Grommes, Phioanh Leia Nghiemphu, Sara Kubek, Barbara Oldrini, Milan G. Chheda, Nicolas Yannuzzi, Hui Tao, Shaojun Zhu, Akio Iwanami, Daisuke Kuga, Julie Dang, Alicia Pedraza, Cameron W. Brennan, Adriana Heguy, Linda M. Liau, Frank Lieberman, W. K. Alfred Yung, Mark R. Gilbert, David A. Reardon, Jan Drappatz, Patrick Y. Wen, Kathleen R. Lamborn, Susan M. Chang, Michael D. Prados, Howard A. Fine, Steve Horvath, Nian Wu, Andrew B. Lassman, Lisa M. DeAngelis, William H. Yong, John G. Kuhn, Paul S. Mischel, Minesh P. Mehta, Timothy F. Cloughesy, Ingo K. Mellinghoff
Journal: Cancer Discovery
Cancer Discov (2012) 2 (5): 458–471.
https://doi.org/10.1158/2159-8290.CD-11-0284
Published: 09 May 2012
View article titled, Differential Sensitivity of Glioma- versus Lung Cancer–Specific EGFR Mutations to EGFR Kinase Inhibitors
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Includes: Multimedia, Supplementary data
Journal Articles

Genomic Complexity and AKT Dependence in Serous Ovarian Cancer

Aphrothiti J. Hanrahan, Nikolaus Schultz, Maggie L. Westfal, Rita A. Sakr, Dilip D. Giri, Stefano Scarperi, Manickam Janikariman, Narciso Olvera, Ellen V. Stevens, Qing-Bai She, Carol Aghajanian, Tari A. King, Elisa de Stanchina, David R. Spriggs, Adriana Heguy, Barry S. Taylor, Chris Sander, Neal Rosen, Douglas A. Levine, David B. Solit
Journal: Cancer Discovery
Cancer Discov (2012) 2 (1): 56–67.
https://doi.org/10.1158/2159-8290.CD-11-0170
Published: 12 January 2012
View article titled, Genomic Complexity and AKT Dependence in Serous Ovarian Cancer
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Includes: Supplementary data