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Adolfo A. Ferrando
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Journal Articles

Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia

Clara Reglero, Chelsea L. Dieck, Arie Zask, Farhad Forouhar, Anouchka P. Laurent, Wen-Hsuan W. Lin, Robert Albero, Hannah I. Miller, Cindy Ma, Julie M. Gastier-Foster, Mignon L. Loh, Liang Tong, Brent R. Stockwell, Teresa Palomero, Adolfo A. Ferrando
Journal: Cancer Discovery
Cancer Discov (2022) 12 (11): 2646–2665.
https://doi.org/10.1158/2159-8290.CD-22-0010
Published: 02 November 2022
View article titled, Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer

Anup Kumar Biswas, Seoyoung Han, Yifan Tai, Wanchao Ma, Courtney Coker, S. Aidan Quinn, Ahmad Rushdi Shakri, Timothy James Zhong, Hanna Scholze, Galina G. Lagos, Angeliki Mela, Katia Manova-Todorova, Elisa de Stanchina, Adolfo A. Ferrando, Cathy Mendelsohn, Peter Canoll, Helena A. Yu, Paul K. Paik, Anjali Saqi, Catherine A. Shu, Mark G. Kris, Joan Massague, Swarnali Acharyya
Journal: Cancer Discovery
Cancer Discov (2022) 12 (4): 1002–1021.
https://doi.org/10.1158/2159-8290.CD-21-0910
Published: 01 April 2022
View article titled, Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in <em>EGFR</em>-Mutant Lung Cancer
Open the PDF for Targeting S100A9–ALDH1A1–Retinoic Acid Signaling to Suppress Brain Relapse in <em>EGFR</em>-Mutant Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia

Marissa Rashkovan, Robert Albero, Francesca Gianni, Pablo Perez-Duran, Hannah I. Miller, Adam L. Mackey, Elisabeth M. Paietta, Martin S. Tallman, Jacob M. Rowe, Mark R. Litzow, Peter H. Wiernik, Selina Luger, Maria Luisa Sulis, Rajesh K. Soni, Adolfo A. Ferrando
Journal: Cancer Discovery
Cancer Discov (2022) 12 (3): 856–871.
https://doi.org/10.1158/2159-8290.CD-21-0551
Published: 08 March 2022
View article titled, Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
Open the PDF for Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia

Jianping Li, Julia Hlavka-Zhang, Jonathan H. Shrimp, Crissandra Piper, Daphne Dupéré-Richér, Jacob S. Roth, Duohui Jing, Heidi L. Casellas Román, Catalina Troche, Alok Swaroop, Marta Kulis, Jon A. Oyer, Christine M. Will, Min Shen, Alberto Riva, Richard L. Bennett, Adolfo A. Ferrando, Matthew D. Hall, Richard B. Lock, Jonathan D. Licht
Journal: Cancer Discovery
Cancer Discov (2022) 12 (1): 186–203.
https://doi.org/10.1158/2159-8290.CD-20-1771
Published: 12 January 2022
View article titled, PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by <em>NSD2</em> Mutation in Pediatric Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia

Lindsey E. Montefiori, Sonja Bendig, Zhaohui Gu, Xiaolong Chen, Petri Pölönen, Xiaotu Ma, Alex Murison, Andy Zeng, Laura Garcia-Prat, Kirsten Dickerson, Ilaria Iacobucci, Sherif Abdelhamed, Ryan Hiltenbrand, Paul E. Mead, Cyrus M. Mehr, Beisi Xu, Zhongshan Cheng, Ti-Cheng Chang, Tamara Westover, Jing Ma, Anna Stengel, Shunsuke Kimura, Chunxu Qu, Marcus B. Valentine, Marissa Rashkovan, Selina Luger, Mark R. Litzow, Jacob M. Rowe, Monique L. den Boer, Victoria Wang, Jun Yin, Steven M. Kornblau, Stephen P. Hunger, Mignon L. Loh, Ching-Hon Pui, Wenjian Yang, Kristine R. Crews, Kathryn G. Roberts, Jun J. Yang, Mary V. Relling, William E. Evans, Wendy Stock, Elisabeth M. Paietta, Adolfo A. Ferrando, Jinghui Zhang, Wolfgang Kern, Torsten Haferlach, Gang Wu, John E. Dick, Jeffery M. Klco, Claudia Haferlach, Charles G. Mullighan
Journal: Cancer Discovery
Cancer Discov (2021) 11 (11): 2846–2867.
https://doi.org/10.1158/2159-8290.CD-21-0145
Published: 01 November 2021
View article titled, Enhancer Hijacking Drives Oncogenic <em>BCL11B</em> Expression in Lineage-Ambiguous Stem Cell Leukemia
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Includes: Supplementary data
Journal Articles

GATA3-Controlled Nucleosome Eviction Drives MYC Enhancer Activity in T-cell Development and Leukemia

Laura Belver, Alexander Y. Yang, Robert Albero, Daniel Herranz, Francesco G. Brundu, S. Aidan Quinn, Pablo Pérez-Durán, Silvia Álvarez, Francesca Gianni, Marissa Rashkovan, Devya Gurung, Pedro P. Rocha, Ramya Raviram, Clara Reglero, Jose R. Cortés, Anisha J. Cooke, Agnieszka A. Wendorff, Valentina Cordó, Jules P. Meijerink, Raúl Rabadan, Adolfo A. Ferrando
Journal: Cancer Discovery
Cancer Discov (2019) 9 (12): 1774–1791.
https://doi.org/10.1158/2159-8290.CD-19-0471
Published: 02 December 2019
View article titled, GATA3-Controlled Nucleosome Eviction Drives <em>MYC</em> Enhancer Activity in T-cell Development and Leukemia
Open the PDF for GATA3-Controlled Nucleosome Eviction Drives <em>MYC</em> Enhancer Activity in T-cell Development and Leukemia in another window
Includes: Supplementary data
Journal Articles

Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL

Agnieszka A. Wendorff, S. Aidan Quinn, Marissa Rashkovan, Chioma J. Madubata, Alberto Ambesi-Impiombato, Mark R. Litzow, Martin S. Tallman, Elisabeth Paietta, Maddalena Paganin, Giuseppe Basso, Julie M. Gastier-Foster, Mignon L. Loh, Raul Rabadan, Pieter Van Vlierberghe, Adolfo A. Ferrando
Journal: Cancer Discovery
Cancer Discov (2019) 9 (3): 436–451.
https://doi.org/10.1158/2159-8290.CD-18-1005
Published: 01 March 2019
View article titled, <em>Phf6</em> Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL
Open the PDF for <em>Phf6</em> Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL in another window
Includes: Supplementary data
Journal Articles

Aberrant Cytokine Production by Nonmalignant Cells in the Pathogenesis of Myeloproliferative Tumors and Response to JAK Inhibitor Therapies

Laura Belver, Adolfo A. Ferrando
Journal: Cancer Discovery
Cancer Discov (2015) 5 (3): 234–236.
https://doi.org/10.1158/2159-8290.CD-15-0095
Published: 05 March 2015
View article titled, Aberrant Cytokine Production by Nonmalignant Cells in the Pathogenesis of Myeloproliferative Tumors and Response to JAK Inhibitor Therapies
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