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Aditya Bardia
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Journal Articles

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

Open Access
Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E. Martin, Bryanna L. Norden, Nicholas Chevalier, Allison M. Kehlmann, Ignaty Leshchiner, Haley Barnes, Sara Ehnstrom, Anastasia-Maria Stavridi, Xin Yuan, Janice S. Kim, Haley Ellis, Alkistis Papatheodoridi, Hakan Gunaydin, Brian P. Danysh, Laxmi Parida, Ioannis Sanidas, Yongli Ji, Kayao Lau, Gerburg M. Wulf, Aditya Bardia, Laura M. Spring, Steven J. Isakoff, Jochen K. Lennerz, Kathryn Del Vecchio, Levi Pierce, Ermira Pazolli, Gad Getz, Ryan B. Corcoran, Dejan Juric
Journal: Cancer Discovery
Cancer Discov (2024) 14 (2): 227–239.
https://doi.org/10.1158/2159-8290.CD-23-0704
Published: 08 February 2024
View articletitled, Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations
Open the PDF for Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations in another window
Includes: Supplementary data
Journal Articles

Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer

Open Access
James T. Coates, Sheng Sun, Ignaty Leshchiner, Nayana Thimmiah, Elizabeth E. Martin, Daniel McLoughlin, Brian P. Danysh, Kara Slowik, Raquel A. Jacobs, Kahn Rhrissorrakrai, Filippo Utro, Chaya Levovitz, Elyssa Denault, Charlotte S. Walmsley, Avinash Kambadakone, James R. Stone, Steven J. Isakoff, Laxmi Parida, Dejan Juric, Gad Getz, Aditya Bardia, Leif W. Ellisen
Journal: Cancer Discovery
Cancer Discov (2021) 11 (10): 2436–2445.
https://doi.org/10.1158/2159-8290.CD-21-0702
Published: 01 October 2021
View articletitled, Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer
Open the PDF for Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Impact of HER2 Heterogeneity on Treatment Response of Early-Stage HER2-Positive Breast Cancer: Phase II Neoadjuvant Clinical Trial of T-DM1 Combined with Pertuzumab

Available to Purchase
Otto Metzger Filho, Giuseppe Viale, Shayna Stein, Lorenzo Trippa, Denise A. Yardley, Ingrid A. Mayer, Vandana G. Abramson, Carlos L. Arteaga, Laura M. Spring, Adrienne G. Waks, Eileen Wrabel, Michelle K. DeMeo, Aditya Bardia, Patrizia Dell'Orto, Leila Russo, Tari A. King, Kornelia Polyak, Franziska Michor, Eric P. Winer, Ian E. Krop
Journal: Cancer Discovery
Cancer Discov (2021) 11 (10): 2474–2487.
https://doi.org/10.1158/2159-8290.CD-20-1557
Published: 01 October 2021
View articletitled, Impact of HER2 Heterogeneity on Treatment Response of Early-Stage HER2-Positive Breast Cancer: Phase II Neoadjuvant Clinical Trial of T-DM1 Combined with Pertuzumab
Open the PDF for Impact of HER2 Heterogeneity on Treatment Response of Early-Stage HER2-Positive Breast Cancer: Phase II Neoadjuvant Clinical Trial of T-DM1 Combined with Pertuzumab in another window
Includes: Supplementary data
Journal Articles

PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer

Free
Carlotta Costa, Ye Wang, Amy Ly, Yasuyuki Hosono, Ellen Murchie, Charlotte S. Walmsley, Tiffany Huynh, Christopher Healy, Rachel Peterson, Shogo Yanase, Charles T. Jakubik, Laura E. Henderson, Leah J. Damon, Daria Timonina, Ioannis Sanidas, Christopher J. Pinto, Mari Mino-Kenudson, James R. Stone, Nicholas J. Dyson, Leif W. Ellisen, Aditya Bardia, Hiromichi Ebi, Cyril H. Benes, Jeffrey A. Engelman, Dejan Juric
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2020) 10 (1): 72–85.
https://doi.org/10.1158/2159-8290.CD-18-0830
Published: 09 January 2020
View articletitled, PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer
Open the PDF for PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers

Available to Purchase
Remi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo, Lin Li, Sara Restrepo-Vassalli, Alan Wang, Negeen Izadian, Matthew MacKay, Byoung-San Moon, Kevin J. Liu, Sathish Kumar Ganesan, Grace Lee, Diane S. Kang, Charlotte S. Walmsley, Christopher Pinto, Michael F. Press, Wange Lu, Janice Lu, Dejan Juric, Aditya Bardia, James Hicks, Bodour Salhia, Frank Attenello, Andrew D. Smith, Min Yu
Journal: Cancer Discovery
Cancer Discov (2020) 10 (1): 86–103.
https://doi.org/10.1158/2159-8290.CD-19-0384
Published: 09 January 2020
View articletitled, Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers
Open the PDF for Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers in another window
Includes: Supplementary data
Journal Articles

A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer

Free
Tanya T. Kwan, Aditya Bardia, Laura M. Spring, Anita Giobbie-Hurder, Mark Kalinich, Taronish Dubash, Tilak Sundaresan, Xin Hong, Joseph A. LiCausi, Uyen Ho, Erin J. Silva, Ben S. Wittner, Lecia V. Sequist, Ravi Kapur, David T. Miyamoto, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2018) 8 (10): 1286–1299.
https://doi.org/10.1158/2159-8290.CD-18-0432
Published: 02 October 2018
View articletitled, A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer
Open the PDF for A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor–Positive Breast Cancer

Free
Karina J. Matissek, Maristela L. Onozato, Sheng Sun, Zongli Zheng, Andrew Schultz, Jesse Lee, Kristofer Patel, Piiha-Lotta Jerevall, Srinivas Vinod Saladi, Allison Macleay, Mehrad Tavallai, Tanja Badovinac-Crnjevic, Carlos Barrios, Nuran Beşe, Arlene Chan, Yanin Chavarri-Guerra, Marcio Debiasi, Elif Demirdögen, Ünal Egeli, Sahsuvar Gökgöz, Henry Gomez, Pedro Liedke, Ismet Tasdelen, Sahsine Tolunay, Gustavo Werutsky, Jessica St. Louis, Nora Horick, Dianne M. Finkelstein, Long Phi Le, Aditya Bardia, Paul E. Goss, Dennis C. Sgroi, A. John Iafrate, Leif W. Ellisen
Journal: Cancer Discovery
Cancer Discov (2018) 8 (3): 336–353.
https://doi.org/10.1158/2159-8290.CD-17-0535
Published: 01 March 2018
View articletitled, Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor–Positive Breast Cancer
Open the PDF for Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor–Positive Breast Cancer in another window
Includes: Supplementary data