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Journal Articles

The Virtual Child

Richard J. Gilbertson, Sam Behjati, Anna-Lisa Böttcher, Marianne E. Bronner, Matthew Burridge, Henrick Clausing, Harry Clifford, Tracey Danaher, Laura K. Donovan, Jarno Drost, Alexander M.M. Eggermont, Chris Emerson, Mona G. Flores, Petra Hamerlik, Nada Jabado, Andrew Jones, Henrick Kaessmann, Claudia L. Kleinman, Marcel Kool, Lena M. Kutscher, Gavin Lindberg, Emily Linnane, John C. Marioni, John M. Maris, Michelle Monje, Alexandra Macaskill, Steven Niederer, Paul A. Northcott, Elizabeth Peeters, Willemijn Plieger-van Solkema, Liane Preußner, Anne C. Rios, Karsten Rippe, Peter Sandford, Nikolaos G. Sgourakis, Adam Shlien, Pete Smith, Karin Straathof, Patrick J. Sullivan, Mario L. Suvà, Michael D. Taylor, Emma Thompson, Roser Vento-Tormo, Brandon J. Wainwright, Robert J. Wechsler-Reya, Frank Westermann, Shannon Winslade, Bissan Al-Lazikani, Stefan M. Pfister
Journal: Cancer Discovery
Cancer Discov (2024) 14 (4): 663–668.
https://doi.org/10.1158/2159-8290.CD-23-1500
Published: 04 April 2024
View articletitled, The Virtual Child
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Journal Articles

Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium

Anirban Das, Nicholas R. Fernandez, Adrian Levine, Vanessa Bianchi, Lucie K. Stengs, Jiil Chung, Logine Negm, Jose Rafael Dimayacyac, Yuan Chang, Liana Nobre, Ayse B. Ercan, Santiago Sanchez-Ramirez, Sumedha Sudhaman, Melissa Edwards, Valerie Larouche, David Samuel, An Van Damme, David Gass, David S. Ziegler, Stefan S. Bielack, Carl Koschmann, Shayna Zelcer, Michal Yalon-Oren, Gadi Abede Campino, Tomasz Sarosiek, Kim E. Nichols, Rebecca Loret De Mola, Kevin Bielamowicz, Magnus Sabel, Charlotta A. Frojd, Matthew D. Wood, Jason M. Glover, Yi-Yen Lee, Magimairajan Vanan, Jenny K. Adamski, Sebastien Perreault, Omar Chamdine, Magnus Aasved Hjort, Michal Zapotocky, Fernando Carceller, Erin Wright, Ivana Fedorakova, Alexander Lossos, Ryuma Tanaka, Michael Osborn, Deborah T. Blumenthal, Melyssa Aronson, Ute Bartels, Annie Huang, Vijay Ramaswamy, David Malkin, Adam Shlien, Anita Villani, Peter B. Dirks, Trevor J. Pugh, Gad Getz, Yosef E. Maruvka, Derek S. Tsang, Birgit Ertl-Wagner, Cynthia Hawkins, Eric Bouffet, Daniel A. Morgenstern, Uri Tabori
Journal: Cancer Discovery
Cancer Discov (2024) 14 (2): 258–273.
https://doi.org/10.1158/2159-8290.CD-23-0559
Published: 08 February 2024
View articletitled, Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium
Open the PDF for Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti–PD-1 Monotherapy: A Report from the International RRD Consortium in another window
Includes: Supplementary data
Journal Articles

Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition

Brittany B. Campbell, Melissa A. Galati, Simone C. Stone, Alexandra N. Riemenschneider, Melissa Edwards, Sumedha Sudhaman, Robert Siddaway, Martin Komosa, Nuno M. Nunes, Liana Nobre, A. Sorana Morrissy, Matthew Zatzman, Michal Zapotocky, Lazar Joksimovic, Sangeetha N. Kalimuthu, David Samuel, Gary Mason, Eric Bouffet, Daniel A. Morgenstern, Melyssa Aronson, Carol Durno, David Malkin, John M. Maris, Michael D. Taylor, Adam Shlien, Trevor J. Pugh, Pamela S. Ohashi, Cynthia E. Hawkins, Uri Tabori
Journal: Cancer Discovery
Cancer Discov (2021) 11 (6): 1454–1467.
https://doi.org/10.1158/2159-8290.CD-20-1050
Published: 01 June 2021
View articletitled, Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition
Open the PDF for Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells

Jiil Chung, Yosef E. Maruvka, Sumedha Sudhaman, Jacalyn Kelly, Nicholas J. Haradhvala, Vanessa Bianchi, Melissa Edwards, Victoria J. Forster, Nuno M. Nunes, Melissa A. Galati, Martin Komosa, Shriya Deshmukh, Vanja Cabric, Scott Davidson, Matthew Zatzman, Nicholas Light, Reid Hayes, Ledia Brunga, Nathaniel D. Anderson, Ben Ho, Karl P. Hodel, Robert Siddaway, A. Sorana Morrissy, Daniel C. Bowers, Valérie Larouche, Annika Bronsema, Michael Osborn, Kristina A. Cole, Enrico Opocher, Gary Mason, Gregory A. Thomas, Ben George, David S. Ziegler, Scott Lindhorst, Magimairajan Vanan, Michal Yalon-Oren, Alyssa T. Reddy, Maura Massimino, Patrick Tomboc, An Van Damme, Alexander Lossos, Carol Durno, Melyssa Aronson, Daniel A. Morgenstern, Eric Bouffet, Annie Huang, Michael D. Taylor, Anita Villani, David Malkin, Cynthia E. Hawkins, Zachary F. Pursell, Adam Shlien, Thomas A. Kunkel, Gad Getz, Uri Tabori
Journal: Cancer Discovery
Series: Author Choice
Cancer Discov (2021) 11 (5): 1176–1191.
https://doi.org/10.1158/2159-8290.CD-20-0790
Published: 01 May 2021
View articletitled, DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells
Open the PDF for DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells in another window
Includes: Supplementary data