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Research Watch August 25 2023
A Chemically Remodeled Cellular Chaperone Targets Active State Mutant KRAS
Cancer Discov (2023)
Research Watch August 25 2023
Pan-Cancer Proteogenomics Uncovers Phenotypes of Cancer Driver Events
Cancer Discov (2023)
Research Watch August 25 2023
Posttranslational Modifications Have Shared Patterns across Tumor Types
Cancer Discov (2023)
Research Article August 25 2023
BCL2 inhibition reveals a dendritic cell-specific immune checkpoint that controls tumor immunosurveillance
Liwei Zhao; Peng Liu; Misha Mao; Shuai Zhang; Camille Bigenwald; Charles-Antoine Dutertre; Christian H. K. Lehmann; Hui Pan; Nicolas Paulhan; Lukas Amon; Aitziber Buque; Takahiro Yamazaki; Lorenzo Galluzzi; Benoit Kloeckner; Aymeric Silvin; Yuhong Pan; Hui Chen; Ai-Ling Tian; Pierre Ly; Diana Dudziak; Laurence Zitvogel; Oliver Kepp; Guido Kroemer
Cancer Discov CD-22-1338.
Research Article August 25 2023
STX-478, a Mutant-Selective, Allosteric PI3Ka Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Ka-Mutant Xenografts
Leonard Buckbinder; David J. St. Jean; Trang Tieu; Brendon Ladd; Brendan Hilbert; Weixue Wang; Jacob T. Alltucker; Samantha Manimala; Gregory V. Kryukov; Natasja Brooijmans; Gregory Dowdell; Philip Jonsson; Michael Huff; Angel Guzman-Perez; Erica L. Jackson; Marcus D. Goncalves; Darrin D. Stuart
Cancer Discov CD-23-0396.
Research Watch August 18 2023
Tissue-Resident Macrophages Play Divergent Roles in Pancreatitis and Cancer
Cancer Discov (2023)
Research Watch August 18 2023
A Cell-Surface MHC-I Inhibitory Axis Promotes Immune Evasion in Cancer
Cancer Discov (2023)
Research Watch August 18 2023
SOSS–INTAC Regulates R-loop Accumulation and Genome Stability
Cancer Discov (2023)
Research Watch August 18 2023
Bacterial Biosensors Detect Tumor DNA and Distinguish Hotspot Mutations
Cancer Discov (2023)
News in Brief August 14 2023
Wildfires Threaten Patients Recovering from NSCLC Surgery
Cancer Discov (2023)
Research Watch August 11 2023
Human STING Enables Transmembrane Proton Transport
Cancer Discov (2023)
Research Watch August 11 2023
CXCL9:SPP1 Macrophage Polarity Is Linked to Clinical Outcome in Cancer
Cancer Discov (2023)
Research Watch August 11 2023
Recurrent DNA Methylation Events Promote IDH-Mutant Gliomagenesis
Cancer Discov (2023)
Research Watch August 11 2023
Normal Skin Mutational Landscapes Reflect Keratinocyte Cancer Incidence
Cancer Discov (2023)
News in Brief August 10 2023
Might Myeloma Trial Point to Novel Study Approach?
Cancer Discov (2023)
Research Article August 8 2023
MRTX1719 is an MTA-cooperative PRMT5 inhibitor that exhibits synthetic lethality in preclinical models and patients with MTAP deleted cancer
Lars D. Engstrom; Ruth Aranda; Laura Waters; Krystal Moya; Vickie Bowcut; Laura Vegar; David Trinh; Allan Hebbert; Christopher R. Smith; Svitlana Kulyk; J David. Lawson; Leo He; Laura D. Hover; Julio Fernandez-Banet; Jill Hallin; Darin Vanderpool; David M. Briere; Alice Blaj; Matthew A. Marx; Jordi Rodon; Michael Offin; Kathryn C. Arbour; Melissa L. Johnson; David J. Kwiatkowski; Pasi A. Janne; Candace L. Haddox; Kyriakos P. Papadopoulos; Jason T. Henry; Konstantinos Leventakos; James G. Christensen; Ronald Shazer; Peter Olson
Cancer Discov CD-23-0669.
Research Watch August 4 2023
The Evolutionary History of Breast Cancer and Related Clones Is Revealed
Cancer Discov (2023)
Research Watch August 4 2023
Genome-wide cfDNA Mutation Profiles Allow for Noninvasive Cancer Detection
Cancer Discov (2023)
Research Watch August 4 2023
HER2 Expression Impacts Trastuzumab Deruxtecan Efficacy in Breast Cancer
Cancer Discov (2023)
Research Watch August 4 2023
A Patient-Centric Trial of Pyrotinib Reveals Clinical Benefit in Lung Cancer
Cancer Discov (2023)
Research Watch June 5 2020
Cancer Markedly and Dynamically Alters the Systemic Immune System
Cancer Discov (2020)
Research Watch September 6 2019
Palmitoylation Alters STAT3 Activity and Tumor Response to High-Fat Diet
Cancer Discov (2019)
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