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Research Article October 7 2024
MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer
Olaf Klingbeil; Damianos Skopelitis; Claudia Tonelli; Toyoki Yoshimoto; Aktan Alpsoy; Maria C. Panepinto; Francesca Minicozzi; Joseph R. Merrill; Amanda M. Cafiero; Disha Aggarwal; Suzanne Russo; Taehoon Ha; Osama E. Demerdash; Tse-Luen Wee; David L. Spector; Scott K. Lyons; David A. Tuveson; Paolo Cifani; Christopher R. Vakoc
Cancer Discov (2024)
Research Article October 7 2024
Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer
Vamsi Mangena; Rony Chanoch-Myers; Rafaela Sartore; Bruna Paulsen; Simon Gritsch; Hannah Weisman; Toshiro Hara; Xandra O. Breakefield; Koen Breyne; Aviv Regev; Kwanghun Chung; Paola Arlotta; Itay Tirosh; Mario L. Suva
Cancer Discov (2024)
Research Article October 3 2024
ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma
Simone Benitz; Alec Steep; Malak M. Nasser; Jonathan Preall; Ujjwal Mukund Mahajan; Holly McQuithey; Ian Loveless; Erick T. Davis; Hui-Ju Wen; Daniel W. Long; Thomas Metzler; Samuel Zwernik; Michaela Louw; Donald Rempinski; Daniel J. Salas-Escabillas; Sydney M. Brender; Linghao Song; Ling Huang; Brian K. Theisen; Zhenyu Zhang; Nina G. Steele; Ivonne Regel; Filip Bednar; Howard C. Crawford
Cancer Discov (2024)
Research Brief October 3 2024
A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer
Anupriya Singhal; Hannah C. Styers; Jonathan Rub; Zhuxuan Li; Stefan R. Torborg; Jung Yun Kim; Olivera Grbovic-Huezo; Huijin Feng; Zeynep Cagla Tarcan; Hulya Sahin Ozkan; Jill Hallin; Olca Basturk; Rona Yaeger; James G. Christensen; Doron Betel; Yan Yan; Iok In Christine Chio; Elisa de Stanchina; Tuomas Tammela
Cancer Discov (2024)
Research Article October 3 2024
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Julien Dilly; Megan T. Hoffman; Laleh Abbassi; Ziyue Li; Francesca Paradiso; Brendan D. Parent; Connor J. Hennessey; Alexander C. Jordan; Micaela Morgado; Shatavisha Dasgupta; Giselle A. Uribe; Annan Yang; Kevin S. Kapner; Felix P. Hambitzer; Li Qiang; Hanrong Feng; Jacob Geisberg; Junning Wang; Kyle E. Evans; Hengyu Lyu; Aislyn Schalck; Ningping Feng; Anastasia M. Lopez; Christopher A. Bristow; Michael P. Kim; Kimal I. Rajapakshe; Vahid Bahrambeigi; Jennifer A. Roth; Kavita Garg; Paola A. Guerrero; Ben Z. Stanger; Simona Cristea; Scott W. Lowe; Timour Baslan; Eliezer M. Van Allen; Joseph D. Mancias; Emily Chan; Abraham Anderson; Yuliya V. Katlinskaya; Alex K. Shalek; David S. Hong; Shubham Pant; Jill Hallin; Kenna Anderes; Peter Olson; Timothy P. Heffernan; Seema Chugh; James G. Christensen; Anirban Maitra; Brian M. Wolpin; Srivatsan Raghavan; Jonathan A. Nowak; Peter S. Winter; Stephanie K. Dougan; Andrew J. Aguirre
Cancer Discov (2024)
Research Article October 2 2024
TIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.
Neibla Priego; Ana de Pablos-Aragoneses; Maria Perea-García; Valentina Pieri; Carolina Hernandez-Oliver; Laura Alvaro-Espinosa; Andrea Rojas; Oliva Sanchez; Ariane Steindl; Eduardo Caleiras; Fernando Garcia; Santiago Garcia-Martin; Osvaldo Grana-Castro; Sandra Garcia-Mulero; Diego Serrano; Paloma Velasco-Beltran; Borja Jimenez-Lasheras; Leire Egia-Mendikute; Luise Rupp; Antonia Stammberger; Matthias Meinhardt; Anas Chaachou-Charradi; Elena Martínez-Saez; Luca Bertero; Paola Cassoni; Luca Mangherini; Alessia Pellerino; Roberta Ruda; Riccardo Soffietti; Fatima Al-Shahrour; Paul Saftig; Rebeca Sanz-Pamplona; Marc Schmitz; Stephen J. Crocker; Alfonso Calvo; Asis Palazon; RENACER Group; Manuel Valiente
Cancer Discov (2024)
Research Article September 30 2024
Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells
Marica Rosaria Ippolito; Johanna Zerbib; Yonatan Eliezer; Eli Reuveni; Sonia Viganò; Giuseppina De Feudis; Eldad D. Shulman; Anouk Savir Kadmon; Rachel Slutsky; Tiangen Chang; Emma M. Campagnolo; Silvia Taglietti; Simone Scorzoni; Sara Gianotti; Sara Martin; Julia Muenzner; Michael Mülleder; Nir Rozenblum; Carmela Rubolino; Tal Ben-Yishay; Kathrin Laue; Yael Cohen-Sharir; Ilaria Vigorito; Francesco Nicassio; Eytan Ruppin; Markus Ralser; Francisca Vazquez; Stefano Santaguida; Uri Ben-David
Cancer Discov (2024)
Research Article September 30 2024
Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model
Yonghong Liu; Jincheng Han; Wen-Hao Hsu; Kyle A. LaBella; Pingna Deng; Xiaoying Shang; Paulino Tallon de Lara; Li Cai; Shan Jiang; Ronald A. DePinho
Cancer Discov (2024)
Research Article September 30 2024
Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers
Jamie E. Medina; Akshaya V. Annapragada; Pien Lof; Sarah Short; Adrianna L. Bartolomucci; Dimitrios Mathios; Shashikant Koul; Noushin Niknafs; Michael Noe; Zachariah H. Foda; Daniel C. Bruhm; Carolyn Hruban; Nicholas A. Vulpescu; Euihye Jung; Renu Dua; Jenna V. Canzoniero; Stephen Cristiano; Vilmos Adleff; Heather Symecko; Daan van den Broek; Lori J. Sokoll; Stephen B. Baylin; Michael F. Press; Dennis J. Slamon; Gottfried E. Konecny; Christina Therkildsen; Beatriz Carvalho; Gerrit A. Meijer; Claus Lindbjerg. Andersen; Susan M. Domchek; Ronny Drapkin; Robert B. Scharpf; Jillian Phallen; Christine A.R. Lok; Victor E. Velculescu
Cancer Discov (2024)
Research Article September 27 2024
DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming
Ilaria Gritti; Jinkai Wan; Vajira Weeresekara; Joel M. Vaz; Giuseppe Tarantino; Tenna Holgersen. Bryde; Vindhya Vijay; Ashwin V. Kammula; Prabhat Kattel; Songli Zhu; Phuong Vu; Marina Chan; Meng-Ju Wu; John D. Gordan; Krushna C. Patra; Vanessa S. Silveira; Robert T. Manguso; Marc N. Wein; Christopher J. Ott; Jun Qi; David Liu; Kei Sakamoto; Taranjit S. Gujral; Nabeel Bardeesy
Cancer Discov (2024)
Research Article September 24 2024
Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non–Small Cell Lung Cancer
Haniel A. Araujo; Ximo Pechuan-Jorge; Teng Zhou; Minh Truong Do; Xin Hu; Frank R. Rojas Alvarez; Maria E. Salvatierra; Heladio P. Ibarguen; Richard Lee; Rashi Raghulan; Harshit Shah; Mariela A. Moreno Ayala; Kevin Chen; Nataliya Tovbis Shifrin; Shuhong Wu; Luisa M. Solis Soto; Marcelo V. Negrao; Don L. Gibbons; David S. Hong; Jack A. Roth; John V. Heymach; Jianjun Zhang; Jingjing Jiang; Mallika Singh; Jacqueline A.M. Smith; Elsa Quintana; Ferdinandos Skoulidis
Cancer Discov (2024)
Science in Society September 24 2024
Advancing Global Health Equity in Oncology Clinical Trial Access
Cancer Discov (2024)
Research Article September 23 2024
Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection
Peter J. Mazzone; Peter B. Bach; Jacob Carey; Caitlin A. Schonewolf; Katalin Bognar; Manmeet S. Ahluwalia; Marcia Cruz-Correa; David Gierada; Sonali Kotagiri; Kathryn Lloyd; Fabien Maldonado; Jesse D. Ortendahl; Lecia V. Sequist; Gerard A. Silvestri; Nichole Tanner; Jeffrey C. Thompson; Anil Vachani; Kwok-Kin Wong; Ali H. Zaidi; Joseph Catallini; Ariel Gershman; Keith Lumbard; Laurel K. Millberg; Jeff Nawrocki; Carter Portwood; Aakanksha Rangnekar; Carolina Campos Sheridan; Niti Trivedi; Tony Wu; Yuhua Zong; Lindsey Cotton; Allison Ryan; Christopher Cisar; Alessandro Leal; Nicholas Dracopoli; Robert B. Scharpf; Victor E. Velculescu; Luke R. G. Pike
Cancer Discov (2024)
Research Article September 18 2024
TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer
Dian Kortleve; Dora Hammerl; Mandy van Brakel; Rebecca Wijers; Daphne Roelofs; Kim Kroese; Mieke M. Timmermans; Chen-Yi Liao; Shaozhuo Huang; Anita Trapman-Jansen; Renée Foekens; Justine Michaux; Monique T.A. de Beijer; Sonja I. Buschow; Jeroen A.A. Demmers; Marleen Kok; Erik H.J. Danen; Michal Bassani-Sternberg; John W.M. Martens; Rachel J.M. Abbott; Reno Debets
Cancer Discov (2024)
Research Brief September 16 2024
Trem2-expressing multinucleated giant macrophages are a biomarker of good prognosis in head and neck squamous cell carcinoma
Gregoire Gessain; Ahmed-Amine Anzali; Marvin Lerousseau; Kevin Mulder; Mathilde Bied; Anne Auperin; Daniel Stockholm; Nicolas Signolle; Farah Sassi; Maria Eugenia Marques Da Costa; Antonin Marchais; Alexandre Sayadi; Daniela Weidner; Stefan Uderhardt; Quentin Blampey; Sumanth Reddy Nakkireddy; Sophie Broutin; Charles-Antoine Dutertre; Pierre Busson; Thomas Walter; Alix Marhic; Antoine Moya-Plana; Joanne Guerlain; Ingrid Breuskin; Odile Casiraghi; Philippe Gorphe; Marion Classe; Jean-Yves Scoazec; Camille Bleriot; Florent Ginhoux
Cancer Discov (2024)
Research Article September 16 2024
AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers
Brian Belmontes; Katherine K. Slemmons; Chun Su; Siyuan Liu; Antonia N. Policheni; Jodi Moriguchi; Hong Tan; Fang Xie; Daniel Andrew. Aiello; Yajing Yang; Raul Lazaro; Famke Aeffner; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Mikkel Vestergaard; Sanne Cowland; Jan Andersson; Ian Sarvary; Qing Chen; Pooja Sharma; Patricia Lopez; Nuria Tamayo; Liping H. Pettus; Sudipa Ghimire-Rijal; Susmith Mukund; Jennifer R. Allen; Jason DeVoss; Angela Coxon; Jordi Rodon; Francois Ghiringhelli; Nicolas Penel; Hans Prenen; Sanne Glad; Chen-Hua Chuang; Kiana Keyvanjah; Danielle M. Townsley; John R. Butler; Matthew P. Bourbeau; Sean Caenepeel; Paul E. Hughes
Cancer Discov (2024)
Research Article September 13 2024
NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations
Jessica J. Lin; Joshua C. Horan; Anupong Tangpeerachaikul; Aurélie Swalduz; Augusto Valdivia; Melissa L. Johnson; Benjamin Besse; D. Ross Camidge; Toshio Fujino; Satoshi Yoda; Linh Nguyen-Phuong; Hayato Mizuta; Ludovic Bigot; Catline Nobre; Jii Bum Lee; Mi Ra Yu; Scot Mente; Yuting Sun; Nancy E. Kohl; James R. Porter; Matthew D. Shair; Viola W. Zhu; Enriqueta Felip; Byoung Chul Cho; Luc Friboulet; Aaron N. Hata; Henry E. Pelish; Alexander Drilon
Cancer Discov (2024)
Research Article September 9 2024
Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers
Birgit Wilding; Lydia Woelflingseder; Anke Baum; Krzysztof Chylinski; Gintautas Vainorius; Neil Gibson; Irene C. Waizenegger; Daniel Gerlach; Martin Augsten; Fiona Spreitzer; Yukina Shirai; Masachika Ikegami; Sylvia Tilandyova; Dirk Scharn; Mark A. Pearson; Johannes Popow; Anna C. Obenauf; Noboru Yamamoto; Shunsuke Kondo; Frans L. Opdam; Annemarie Bruining; Shinji Kohsaka; Norbert Kraut; John V. Heymach; Flavio Solca; Ralph A. Neumuller
Cancer Discov (2024)
Research Article August 30 2024
T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study
Justin F. Gainor; Manish R. Patel; Jeffrey S. Weber; Martin Gutierrez; Julie E. Bauman; Jeffrey M. Clarke; Ricklie Julian; Aaron J. Scott; Jessica L. Geiger; Kedar Kirtane; Celine Robert-Tissot; Brandon Coder; Moomal Tasneem; Jing Sun; Wei Zheng; Lauren Gerbereux; Andressa Laino; Filippos Porichis; Jack Russella Pollard; Peijie Hou; Vasudha Sehgal; Xing Chen; Manju Morrissey; Hikmat N. Daghestani; Igor Feldman; Lakshmi Srinivasan; Joshua P. Frederick; Michelle Brown; Praveen Aanur; Robert Meehan; Howard A. Burris, III
Cancer Discov (2024)
Research Article August 29 2024
Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Bruno Giotti; Komal Dolasia; William Zhao; Peiwen Cai; Robert Sweeney; Elliot Merritt; Evgeny Kiner; Grace S. Kim; Atharva Bhagwat; Thinh Nguyen; Samarth Hegde; Bailey G. Fitzgerald; Sanjana Shroff; Travis Dawson; Monica Garcia-Barros; Jamshid Abdul-Ghafar; Rachel Chen; Sacha Gnjatic; Alan Soto; Rachel Brody; Seunghee Kim-Schulze; Zhihong Chen; Kristin G. Beaumont; Miriam Merad; Raja M. Flores; Robert P. Sebra; Amir Horowitz; Thomas U. Marron; Anna Tocheva; Andrea Wolf; Alexander M. Tsankov
Cancer Discov (2024)
Research Article August 29 2024
The SCRUM-MONSTAR Cancer-Omics Ecosystem: Striving for a Quantum Leap in Precision Medicine
Tadayoshi Hashimoto; Yoshiaki Nakamura; Takao Fujisawa; Mitsuho Imai; Taro Shibuki; Naoko Iida; Hiroshi Ozaki; Norio Nonomura; Chigusa Morizane; Hiroji Iwata; Susumu Okano; Wataru Yamagami; Naoya Yamazaki; Shigenori Kadowaki; Hiroya Taniguchi; Makoto Ueno; Shogen Boku; Eiji Oki; Yoshito Komatsu; Satoshi Yuki; Akitaka Makiyama; Tomoyuki Otsuka; Hiroki Hara; Naohiro Okano; Tomohiro Nishina; Yasutoshi Sakamoto; Izumi Miki; Shin Kobayashi; Junichiro Yuda; Shun-Ichiro Kageyama; Michiko Nagamine; Shingo Sakashita; Naoya Sakamoto; Riu Yamashita; Yoshikatsu Koga; Hideaki Bando; Genichiro Ishii; Takeshi Kuwata; Woong-Yang Park; Atsushi Ohtsu; Takayuki Yoshino
Cancer Discov (2024)
Research Article August 27 2024
RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
Nana Adjoa Ben-Crentsil; Wazim Mohammed Ismail; Maria E. Balasis; Hannah Newman; Ariel Quintana; Moritz Binder; Traci Kruer; Surendra Neupane; Meghan C. Ferrall-Fairbanks; Jenna Fernandez; Terra L. Lasho; Christy M. Finke; Mohammed L. Ibrahim; Kathy L. McGraw; Michael Wysota; Amy L. Aldrich; Christopher B. Ryder; Christopher T. Letson; Joshua Traina; Amy F. McLemore; Nathalie Droin; Aditi Shastri; Seongseok Yun; Eric Solary; David A. Sallman; Amer A. Beg; Li Ma; Alexandre Gaspar-Maia; Mrinal M. Patnaik; Eric Padron
Cancer Discov (2024)
Research Article August 26 2024
Chromothripsis-mediated small cell lung carcinoma
Natasha Rekhtman; Sam E. Tischfield; Christopher A. Febres-Aldana; Jake June-Koo. Lee; Jason C. Chang; Benjamin O. Herzberg; Pier Selenica; Hyung Jun Woo; Chad M. Vanderbilt; Soo-Ryum Yang; Fei Xu; Anita S. Bowman; Edaise M. da Silva; Anne Marie Noronha; Diana L. Mandelker; Miika Mehine; Semanti Mukherjee; Juan Blanco-Heredia; John J. Orgera; Gouri J. Nanjangud; Marina K. Baine; Rania G. Aly; Jennifer L. Sauter; William D. Travis; Omid Savari; Andre L. Moreira; Christina J. Falcon; Francis M. Bodd; Christina E. Wilson; Jacklynn V. Sienty; Parvathy Manoj; Harsha Sridhar; Lu Wang; Noura J. Choudhury; Michael Offin; Helena A. Yu; Alvaro Quintanal-Villalonga; Michael F. Berger; Marc Ladanyi; Mark T.A. Donoghue; Jorge S. Reis-Filho; Charles M. Rudin
Cancer Discov (2024)
Research Brief August 16 2024
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors
Ju-Fang Chang; Jack H. Landmann; Tien-Ching Chang; Mehmet Emrah Selli; Yangdon Tenzin; John M. Warrington; Julie Ritchey; Yu-Sung Hsu; Michael Slade; Deepesh Kumar Gupta; John F. DiPersio; Alex S. Holehouse; Nathan Singh
Cancer Discov (2024)
Research Article August 13 2024
Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression.
Hiroki Kobayashi; Tadashi Iida; Yosuke Ochiai; Ermanno Malagola; Xiaofei Zhi; Ruth A. White; Jin Qian; Feijing Wu; Quin T. Waterbury; Ruhong Tu; Biyun Zheng; Jonathan S. LaBella; Leah B. Zamechek; Atsushi Ogura; Susan L. Woods; Daniel L. Worthley; Atsushi Enomoto; Timothy C. Wang
Cancer Discov (2024)
Research Article August 13 2024
The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma
Shiyan Wang; Yong Zeng; Lin Zhu; Min Zhang; Lei Zhou; Weixiong Yang; Weishan Luo; Lina Wang; Yanming Liu; Helen Zhu; Xin Xu; Peiran Su; Xinyue Zhang; Musaddeque Ahmed; Wei Chen; Moliang Chen; Sujun Chen; Mykhaylo Slobodyanyuk; Zhongpeng Xie; Jiansheng Guan; Wen Zhang; Aafaque Ahmad Khan; Shingo Sakashita; Ni Liu; Nhu-An Pham; Paul C. Boutros; Zunfu Ke; Michael F. Moran; Zongwei Cai; Chao Cheng; Jun Yu; Ming S. Tsao; Housheng H. He
Cancer Discov (2024)
Research Article August 12 2024
Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers
Patrick Loi; Amy E. Schade; Carrie L. Rodriguez; Anjana Krishnan; Naiara Perurena; Van T.M. Nguyen; Yilin Xu; Marina Watanabe; Rachel A. Davis; Alycia Gardner; Natalie F. Pilla; Kaia Mattioli; Olesja Popow; Nuray Gunduz; Tamsin R.M. Lannagan; Samantha Fitzgerald; Ewa T. Sicinska; Jia-Ren Lin; William Tan; Lauren K. Brais; Kevin M. Haigis; Marios Giannakis; Kimmie Ng; Sandro Santagata; Kristian Helin; Owen J. Sansom; Karen Cichowski
Cancer Discov (2024)
Research Brief August 7 2024
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair
John C. Rose; Julia A. Belk; Ivy Tsz-Lo. Wong; Jens Luebeck; Hudson T. Horn; Bence Daniel; Matthew G. Jones; Kathryn E. Yost; King L. Hung; Kevin S. Kolahi; Ellis J. Curtis; Calvin J. Kuo; Vineet Bafna; Paul S. Mischel; Howard Y. Chang
Cancer Discov (2024)
Research Article July 31 2024
Botensilimab, an Fc-enhanced anti-CTLA-4 antibody, is effective against tumors poorly responsive to conventional immunotherapy
Dhan Chand; David A. Savitsky; Shanmugarajan Krishnan; Gabriel Mednick; Chloe Delepine; Pilar Garcia-Broncano; Kah Teong Soh; Wei Wu; Margaret K. Wilkens; Olga Udartseva; Sylvia Vincent; Bishnu Joshi; Justin G. Keith; Mariana Manrique; Marilyn Marques; Antoine Tanne; Daniel L. Levey; Haiyong Han; Serina Ng; Jackson Ridpath; Olivia Huber; Benjamin Morin; Claire Galand; Sean Bourdelais; Randi B. Gombos; Rebecca Ward; Yu Qin; Jeremy D. Waight; Matthew R. Costa; Alvaro Sebastian-Yague; Nils-Petter Rudqvist; Malgorzata Pupecka-Swider; Vignesh Venkatraman; Andrew Slee; Jaymin M. Patel; Joseph E. Grossman; Nicholas S. Wilson; Daniel D. Von Hoff; Justin Stebbing; Tyler J. Curiel; Jennifer S. Buell; Steven J. O'Day; Robert B. Stein
Cancer Discov (2024)
Research Article July 31 2024
Identification and characterization of chemotherapy resistant high-risk neuroblastoma persister cells
Liron D. Grossmann; Chia-Hui Chen; Yasin Uzun; Anusha Thadi; Adam J. Wolpaw; Kevin Louault; Yael Goldstein; Lea F. Surrey; Daniel Martinez; Matteo Calafatti; Mark Gerelus; Peng Gao; Lobin Lee; Khushbu Patel; Rebecca S. Kaufman; Guy Shani; Alvin Farrel; Sharon Moshitch-Moshkovitz; Paris Grimaldi; Matthew Shapiro; Nathan M. Kendsersky; Jarrett M. Lindsay; Colleen E. Casey; Kateryna Krytska; Laura Scolaro; Matthew Tsang; David Groff; Smita Matkar; Josh R. Kalna; Emily Mycek; Jayne McDevitt; Erin Runbeck; Tasleema Patel; Kathrin M. Bernt; Shahab Asgharzadeh; Yves A. DeClerck; Yael P. Mosse; Kai Tan; John M. Maris
Cancer Discov (2024)
Research Article July 22 2024
A targetable secreted neural protein drives pancreatic cancer metastatic colonization and HIF1a nuclear retention
Norihiro Yamaguchi; Y Gloria Wu; Ethan Ravetch; Mai Takahashi; Abdul G. Khan; Akimasa Hayashi; Wenbin Mei; Dennis Hsu; Shigeaki Umeda; Elisa de Stanchina; Ivo C. Lorenz; Christine A. Iacobuzio-Donahue; Sohail F. Tavazoie
Cancer Discov (2024)
Research Watch December 21 2023
A B3GALT6-Regulated Network Drives Dormant Breast Cancer Cell Survival
Cancer Discov (2023)
Research Watch December 21 2023
IL-2-STAT5 Activity Antagonizes TOX and Reverses CD8+ T Cell Exhaustion
Cancer Discov (2023)
Research Watch December 21 2023
Divarasib Plus Cetuximab Is Safe and Has Efficacy in Colorectal Cancer
Cancer Discov (2023)
Research Watch December 21 2023
A Gut Hormone Mediates Renal Dysfunction in the Absence of Chemotherapy
Cancer Discov (2023)
Research Watch December 15 2023
Prostate Cell Lineage Identities Are Governed by Distinct Metabolomes
Cancer Discov (2023)
Research Watch December 15 2023
IL4 Signaling in the Bone Marrow Promotes Protumorigenic Myelopoiesis
Cancer Discov (2023)
Research Watch December 15 2023
Metastasis-Associated Circulating T Cells Are Phenotypically Distinct
Cancer Discov (2023)
Research Watch December 15 2023
Oncogenic Mutations Control Stem Cell Polarization in Colorectal Cancer
Cancer Discov (2023)
Research Watch December 15 2023
The Structural Principles of PC-CARs Can Expand Therapeutic Application
Cancer Discov (2023)
News in Brief December 12 2023
Oral Arsenic Regimen for APL Deemed “Revolutionary”
Cancer Discov (2023)
News in Brief December 11 2023
Artificial Intelligence Identifies Novel Disease Pathways
Cancer Discov (2023)
News in Depth December 11 2023
ImmunoGen Takeover Caps Year of Record ADC Investments
Cancer Discov (2023)
Research Watch December 8 2023
ASCL1 and ASCL2 Define Distinct States of Neuroendocrine Prostate Cancer
Cancer Discov (2023)
Research Watch December 8 2023
Trans-vaccenic Acid Reprograms CD8+ T Cells and Enhances Antitumor Immunity
Cancer Discov (2023)
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