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Research Watch November 22 2023
Short-Read Sequencing Detects Large Structural Variants in Cancer Genomes
Cancer Discov (2023)
Research Watch November 22 2023
Vitamin B5 Supports Oncogenic Metabolism in MYC-Driven Breast Cancer
Cancer Discov (2023)
News in Brief November 22 2023
Tertiary Lymphoid Structures Validated as Biomarker
Cancer Discov (2023)
Research Article November 20 2023
ESR1 F404 mutations and acquired resistance to fulvestrant in ESR1 mutant breast cancer
Belinda Kingston; Alex Pearson; Maria Teresa Herrera-Abreu; Li-Xuan Sim; Rosalind J. Cutts; Heena Shah; Laura Moretti; Lucy S. Kilburn; Hannah Johnson; Iain R. Macpherson; Alistair Ring; Judith M. Bliss; Yingwei Hou; Weiyi Toy; John A. Katzenellenbogen; Sarat Chandarlapaty; Nicholas C. Turner
Cancer Discov (2023)
Research Watch November 17 2023
Intracellular Oncoproteins Can Be Targeted by Mutation-Specific Dimeric IgA
Cancer Discov (2023)
Research Watch November 17 2023
MAF and ERα Coordinately Drive Metastatic Programs in Breast Cancer
Cancer Discov (2023)
Research Article November 17 2023
Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer
Sandra Santasusagna; Shijia Zhu; Vijayakumar Jawalagatti; Marc Carceles-Cordon; Adam Ertel; Saioa Garcia-Longarte; Won-Min Song; Naoto Fujiwara; Peiyao Li; Isabel Mendizabal; Daniel P. Petrylak; William Kevin Kelly; E. Premkumar Reddy; Liguo Wang; Matthew J. Schiewer; Amaia Lujambio; Jeffrey Karnes; Karen E. Knudsen; Carlos Cordon-Cardo; Haidong Dong; Haojie Huang; Arkaitz Carracedo; Yujin Hoshida; Veronica Rodriguez-Bravo; Josep Domingo-Domenech
Cancer Discov (2023)
Research Watch November 17 2023
Claudin-6 CAR T Cells Are Safe and Have Potential Clinical Activity
Cancer Discov (2023)
Research Watch November 17 2023
Cancer Cells Adapt to SWI/SNF Inhibition through Compensatory EP400 Function
Cancer Discov (2023)
News in Brief November 16 2023
Checkpoint Inhibitors Up Survival in Early-Stage Lung Cancer
Cancer Discov (2023)
Research Article November 15 2023
Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Marie C. Hasselluhn; Amanda R. Decker-Farrell; Lukas Vlahos; Dafydd H. Thomas; Alvaro Curiel-Garcia; H. Carlo Maurer; Urszula N. Wasko; Lorenzo Tomassoni; Stephen A. Sastra; Carmine F. Palermo; Tanner C. Dalton; Alice Ma; Fangda Li; Ezequiel J. Tolosa; Hanina Hibshoosh; Martin E. Fernandez-Zapico; Alexander Muir; Andrea Califano; Kenneth P. Olive
Cancer Discov (2023)
Research Article November 14 2023
Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Pierre Bercier; Qian Qian Wang; Ning Zang; Jie Zhang; Chang Yang; Yasen Maimaitiyiming; Majdouline Abou-Ghali; Caroline Berthier; Chengchen Wu; Michiko Niwa-Kawakita; Thassadite Dirami; Marie-Claude Geoffroy; Omar Ferhi; Samuel Quentin; Shirine Benhenda; Yasumitsu Ogra; Zoher Gueroui; Chun Zhou; Hua Naranmandura; Hugues de Thé; Valérie Lallemand-Breitenbach
Cancer Discov (2023)
News in Brief November 13 2023
ARPA-H Funds Two “Manhattan Projects” for Cancer
Cancer Discov (2023)
Research Watch November 10 2023
CAN-3110 Induces Immunoactivation in Recurrent Glioblastoma
Cancer Discov (2023)
Research Watch November 10 2023
Gliomas Hijack Adaptive Plasticity to Strengthen Neuron–Tumor Synapses
Cancer Discov (2023)
Research Watch November 10 2023
Transposable Element Signatures Define Stages of T-cell Exhaustion
Cancer Discov (2023)
Research Watch November 10 2023
Toxic UDPGA Accumulation Is a Metabolic Vulnerability of Cancer Cells
Cancer Discov (2023)
News in Brief November 8 2023
Personalized DNA Vaccine Immunogenic Against Melanoma
Cancer Discov (2023)
Research Article November 7 2023
Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells.
Chunbo He; Dezhen Wang; Surendra K. Shukla; Tuo Hu; Ravi Thakur; Xiao Fu; Ryan J. King; Sai Sundeep Kollala; Kuldeep S. Attri; Divya Murthy; Nina V. Chaika; Yuki Fujii; Daisy Gonzalez; Camila G. Pacheco; Yudong Qiu; Pankaj K. Singh; Jason W. Locasale; Kamiya Mehla
Cancer Discov (2023)
Research Article November 7 2023
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma
Zhuxuan Li; Xueqian Zhuang; Chun-Hao Pan; Yan Yan; Rohit Thummalapalli; Jill Hallin; Stefan R. Torborg; Anupriya Singhal; Jason C. Chang; Eusebio Manchado; Lukas E. Dow; Rona Yaeger; James G. Christensen; Scott W. Lowe; Charles M. Rudin; Simon Joost; Tuomas Tammela
Cancer Discov (2023)
Research Article November 7 2023
SUV39H1 Ablation Enhances Long-Term CAR-T Function in Solid Tumors
Sheila Lopez-Cobo; Jaime R. Fuentealba; Paul Gueguen; Pierre-Emmanuel Bonte; Kyriaki Tsalkitzi; Irena Chacon; Salome Glauzy; Armelle Bohineust; Ariane Biquand; Lisseth Silva; Zelia Gouveia; Christel Goudot; Franck Perez; Michael Saitakis; Sebastian Amigorena
Cancer Discov (2023)
Research Article November 7 2023
Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function
Nayan Jain; Zeguo Zhao; Richard P. Koche; Chenling Antelope; Yosi Gozlan; Antonino Montalbano; David Brocks; Michael Lopez; Anton Dobrin; Yuzhe Shi; Gertrude Gunset; Theodoros Giavridis; Michel Sadelain
Cancer Discov (2023)
Research Article November 6 2023
First in Human Study of the Reversible BTK Inhibitor Nemtabrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia and B-Cell Non-Hodgkin Lymphoma
Jennifer A. Woyach; Deborah M. Stephens; Ian W. Flinn; Seema A. Bhat; Ronald E. Savage; Feng Chai; Sudharshan Eathiraj; Sean D. Reiff; Elizabeth M. Muhowski; Lindsey Granlund; Lyndsey Szuszkiewicz; Wayne Wang; Brian Schwartz; Razi Ghori; Mohammed Z.H. Farooqui; John C. Byrd
Cancer Discov (2023)
Research Watch November 3 2023
SRCAP Mutations and Cellular Stressors Promote Clonal Hematopoiesis
Cancer Discov (2023)
Research Watch November 3 2023
Clinically Actionable Alterations Are Associated with African Ancestry
Cancer Discov (2023)
Research Watch November 3 2023
Tebotelimab Is Safe and Effective Across Multiple Cancer Types
Cancer Discov (2023)
Research Article November 2 2023
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia
Andreas Varkaris; Ermira Pazolli; Hakan Gunaydin; Qi Wang; Levi Pierce; Alessandro A. Boezio; Artemisa Bulku; Lucian DiPietro; Cary Fridrich; Adam Frost; Fabrizio Giordanetto; Erika P. Hamilton; Katherine Harris; Michael Holliday; Tamieka L. Hunter; Amanda Iskandar; Yongli Ji; Alexandre Larivée; Jonathan R. LaRochelle; Andre Lescarbeau; Fabien Llambi; Brenda Lormil; Mary M. Mader; Brenton G. Mar; Iain Martin; Thomas H. McLean; Klaus Michelsen; Yakov Pechersky; Erika Puente-Poushnejad; Kevin Raynor; Dipali Rogala; Ramin Samadani; Alison M. Schram; Kelley Shortsleeves; Sweta Swaminathan; Shahein Tajmir; Gege Tan; Yong Tang; Roberto Valverde; Bryan Wehrenberg; Jeremy Wilbur; Bret R. Williams; Hongtao Zeng; Hanmo Zhang; W Patrick. Walters; Beni B. Wolf; David E. Shaw; Donald A. Bergstrom; James Watters; James S. Fraser; Pascal D. Fortin; D. Randal Kipp
Cancer Discov (2023)
Research Brief November 2 2023
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations.
Andreas Varkaris; Ferran Fece de la Cruz; Elizabeth E. Martin; Bryanna L. Norden; Nicholas Chevalier; Allison M. Kehlmann; Ignaty Leshchiner; Haley Barnes; Sara Ehnstrom; Anastasia-Maria Stavridi; Xin Yuan; Janice S. Kim; Haley Ellis; Alkistis Papatheodoridi; Hakan Gunaydin; Brian P. Danysh; Laxmi Parida; Ioannis Sanidas; Yongli Ji; Kayao Lau; Gerburg M. Wulf; Aditya Bardia; Laura M. Spring; Steven J. Isakoff; Jochen K. Lennerz; Levi Pierce; Ermira Pazolli; Gad Getz; Ryan B. Corcoran; Dejan Juric
Cancer Discov (2023)
Research Article October 30 2023
GTP signaling links metabolism, DNA repair, and responses to genotoxic stress
Weihua Zhou; Zitong Zhao; Angelica Lin; John Z. Yang; Jie Xu; Kari Wilder-Romans; Annabel Yang; Jing Li; Sumeet Solanki; Jennifer M. Speth; Natalie Walker; Andrew J. Scott; Lu Wang; Bo Wen; Anthony Andren; Li Zhang; Ayesha U. Kothari; Yangyang Yao; Erik R. Peterson; Navyateja Korimerla; Christian K. Werner; Alexander Ullrich; Jessica Liang; Janna Jacobson; Sravya Palavalasa; Alexandra M. O’Brien; Ameer L. Elaimy; Sean P. Ferris; Shuang G. Zhao; Jann N. Sarkaria; Balazs Gyorffy; Shuqun Zhang; Wajd N. Al-Holou; Yoshie Umemura; Meredith A. Morgan; Theodore S. Lawrence; Costas A. Lyssiotis; Marc Peters-Golden; Yatrik M. Shah; Daniel R. Wahl
Cancer Discov (2023)
Research Watch October 27 2023
Mitochondrial DNA Release Is Induced by Apoptotic Stress and Drives the SASP
Cancer Discov (2023)
Research Watch October 27 2023
CD36 Protects Tumor Cells from Lipotoxicity During Metastasis
Cancer Discov (2023)
Research Watch October 27 2023
Tumoral Lactobacillus iners Induces Therapy Resistance Through Metabolic Rewiring
Cancer Discov (2023)
Research Watch October 27 2023
Probiotic-Guided CAR T cells Promote Antigen-Agnostic Solid Tumor Cytotoxicity
Cancer Discov (2023)
Research Article October 25 2023
Loss-of-function but not gain-of-function properties of mutant TP53 are critical for the proliferation, survival and metastasis of a broad range of cancer cells
Zilu Wang; Matteo Burigotto; Sabrina Ghetti; Francois Vaillant; Tao Tan; Bianca D. Capaldo; Michelle Palmieri; Yumiko Hirokawa; Lin Tai; Daniel S. Simpson; Catherine Chang; Allan Shuai. Huang; Elizabeth Lieschke; Sarah T. Diepstraten; Deeksha Kaloni; Chris Riffkin; David C.S. Huang; Connie SN. Li Wai Suen; Alexandra L. Garnham; Peter Gibbs; Jane E. Visvader; Oliver M. Sieber; Marco J. Herold; Luca L. Fava; Gemma L. Kelly; Andreas Strasser
Cancer Discov (2023)
News in Depth October 24 2023
Selpercatinib Shifts Treatment Paradigm for MTC and NSCLC
Cancer Discov (2023)
Research Article October 24 2023
Early Cancer Detection in Li-Fraumeni Syndrome with Cell-Free DNA
Derek Wong; Ping Luo; Leslie E. Oldfield; Haifan Gong; Ledia Brunga; Ron Rabinowicz; Vallijah Subasri; Clarissa Chan; Tiana Downs; Kirsten M. Farncombe; Beatrice Luu; Maia Norman; Julia A. Sobotka; Precious Uju; Jenna Eagles; Stephanie Pedersen; Johanna Wellum; Arnavaz Danesh; Stephenie D. Prokopec; Eric Y. Stutheit-Zhao; Nadia Znassi; Lawrence E. Heisler; Richard Jovelin; Bernard Lam; Beatriz E. Lujan Toro; Kayla Marsh; Yogi Sundaravadanam; Dax Torti; Carina Man; Anna Goldenberg; Wei Xu; Patrick Veit-Haibach; Andrea S. Doria; David Malkin; Raymond H. Kim; Trevor J. Pugh
Cancer Discov (2023)
News in Brief October 23 2023
Expanding “Practice-Changing” Belzutifan's Reach in RCC
Cancer Discov (2023)
Research Article October 23 2023
p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression
Gizem Efe; Karen J. Dunbar; Kensuke Sugiura; Katherine Cunningham; Saul Carcamo; Spyros Karaiskos; Qiaosi Tang; Ricardo Cruz-Acuña; Lois Resnick-Silverman; Jessica Peura; Chao Lu; Dan Hasson; Andres J. Klein-Szanto; Alison M. Taylor; James J. Manfredi; Carol Prives; Anil K. Rustgi
Cancer Discov (2023)
Research Watch October 20 2023
MERCI Predicts Mitochondrial Transfer from T Cells to Tumor Cells
Cancer Discov (2023)
Research Watch October 20 2023
Arginine Promotes Metabolic Reprogramming and Liver Tumorigenesis
Cancer Discov (2023)
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