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Research Brief

Liquid biopsy profiling of prediagnostic specimens from patients with follicular lymphoma (FL) identified key founder mutations in common precursor cells, including CREBBP KAT domain lesions detectable years before FL diagnosis.

Research Articles

Comprehensive characterization of the healthy adult human pancreas reveals frequent neoplastic lesions with a unique microenvironment and early activation of neoplastic pathways.

Barrett's esophagus and gastric intestinal metaplasia are molecularly similar precancerous lesions, with epithelial cells being mosaics of gastric and intestinal phenotypes and stromal cells showing features of cancer-associated fibroblasts.

Metastatic melanoma evolution was illustrated through research autopsy and extensive multiomic profiling and revealed the diverse routes to treatment resistance, including extensive copy-number alterations, mutations in key drivers, and extrachromosomal DNA.

Two transcriptome-based tools predicted sensitivity of patient-derived xenograft models to antineoplastic drugs, suggesting the clinical utility of these approaches.

Combinatorial levels of BCL2 family members in acute myeloid leukemia stem cells are a key denominator of response to BCL2 inhibitor therapy, and flow cytometry–based measurements predict response in patients both reliably and quickly.

In pancreatic cancers harboring high-risk genomes, cancer cell–neutrophil Cxcl1–TNF signaling dictates immunosuppression and stromal inflammation and offers a novel framework by which targeting context-dependent TNF signaling may overcome therapeutic resistance.

Pharmacologic targeting of immune stromal p38MAPKα signaling limits immunosuppressive macrophages and increases Th1 CD4+ T-cell activation in breast metastases, rendering tumors more susceptible to agonist anti-OX40 immunotherapy.

Positive-selection CRISPR–Cas9 screens identified members of the KDM5 family of H3K4 histone lysine demethylases as functionally relevant tumor suppressor targets of (R)-2HG in IDH-mutant acute myeloid leukemia and glioma.

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Clinical Trials
Immunology
Gastric Cancer
Microbiome
Pediatric Cancers
Immune Evasion
Pancreatic Cancer
Neuroblastoma
Metastasis
Risk Factors
Telomeres

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