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Research Brief

This consortium study defined distinct somatic cancer gene mutation patterns by race/ethnicity and sex among patients with early-onset colorectal cancer (CRC), yielding novel biological clues into early-onset CRC disparities.

Research Articles

CD19/CD20 bispecific CAR-T cells enriched in naive and memory phenotypes achieve robust antitumor efficacy and durability of response with minimal toxicity in patients with relapsed and refractory non-Hodgkin lymphoma.

NVL-520, a selective macrocyclic inhibitor of ROS1, demonstrated antitumor activity in patient case studies of ROS1 inhibitor–refractory lung cancers without observed neurologic toxicities attributed to TRK inhibition.

A machine learning model using multifeature fragmentome data from genome-wide cell-free DNA analyses detected hepatocellular carcinoma with high sensitivity and specificity in average and high-risk populations, including in early-stage disease.

New methods for the analysis of circulating tumor DNA from patient-derived xenograft plasma inform on tumor gene regulation and provide a blood-based signature for classifying prostate cancer phenotypes in clinical patient samples.

Multiomic profiling of malignant peripheral nerve sheath tumors reveals genomic events that underlie tumor evolution including extensive somatic copy-number alterations (SCNA), with detection of specific SCNAs in cell-free DNA being able to predict prognosis.

The computational tool BipotentR was used to reveal drug targets that can inhibit tumor growth by concurrent immune activation and inhibition of a separate oncogenic pathway, leading to identification of ESRRA as a top immune–metabolic target.

LZTR1 mutations stabilize and activate EGFR and AXL proteins in cancer, thus conferring specific vulnerability of LZTR1-mutant cancers to combination treatment with EGFR and AXL inhibitors.

Mutant NPM1 in leukemia obtains neomorphic activity to hijack active HOXA/B and MEIS1 transcription on chromatin via the association of XPO1 and blocks the histone deacetylase activity associated with myeloid differentiation.

NPM1c is recruited to self-renewal–associated genes and enhances their transcription in cooperation with the MLL histone methyltransferase complex, which can be targeted by Menin–MLL inhibitors.

The survival of a subset of carcinoma cells is dependent on the function of the BIRC6 ubiquitin ligase complex, which prevents aberrant activation of the integrated stress response via degradation of the HRI kinase.

News in Brief

Research Watch

Drug Resistance
Breast Cancer
Nucleic Acids
Early Detection
Colorectal Cancer
Esophageal Cancer
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