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In the Spotlight
Science in Society
Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients
Temozolomide treatment in patients with metastatic colorectal cancer led to inactivation of mismatch repair genes and increased tumor mutational burden that could be monitored in the tissue and blood.
Sunvozertinib, a Selective EGFR Inhibitor for Previously Treated Non–Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations
In both preclinical models and two phase I clinical trials of non–small cell lung cancer with EGFR exon 20 mutations, the selective EGFR inhibitor sunvozertinib demonstrated manageable safety and antitumor activity.
Longitudinal Undetectable Molecular Residual Disease Defines Potentially Cured Population in Localized Non–Small Cell Lung Cancer
A prospective observational study confirms the value of molecular residual disease (MRD) for patients with stage I–IIIA non–small cell lung cancer after resection, highlighting the negative predictive value of longitudinal undetectable MRD.
A synthetic essentiality framework identified tryptophan 2,3-dioxygenase 2 (TDO2) as an essential effector of APC-deficient tumorigenesis, and its inhibition blocks kynurenine–aryl hydrocarbon receptor–induced glycolysis and tumor immune suppression.
IFNα Potentiates Anti–PD-1 Efficacy by Remodeling Glucose Metabolism in the Hepatocellular Carcinoma Microenvironment
Dual treatment with IFNα and anti–PD-1-based immunotherapies may be an effective combination strategy for patients with hepatocellular carcinoma.
Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1
Among common dietary supplements, vitamin E intake increases cancer immunotherapy responses by directly inhibiting the SHP1 checkpoint in dendritic cells, which improves antigen presentation and activates T-cell antitumor immunity.
The detection of IRF2BP2 at the intersection of cell-intrinsic inflammatory signaling and acute myeloid leukemia (AML) dependencies suggests cell-intrinsic hyperinflammation as a vulnerability of AML.
SETD2 Haploinsufficiency Enhances Germinal Center–Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis
SETD2 heterozygous deletion in diffuse large B-cell lymphoma is associated with somatic hypermutation induced by the enzyme AICDA, leading to DNA damage, reduced apoptosis, and increased lymphomagenesis.
MOZ and Menin–MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
Dependency screening in gastrointestinal stromal tumor identified MOZ and Menin–MLL complexes as complementary chromatin regulators and therapeutic vulnerabilities that control oncogenic transcriptional programs.
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