In This Issue
In the Spotlight
Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study
Atezolizumab shows promising activity with durable responses in immunotherapy-naive patients with a tumor mutation burden (TMB) of ≥16 mut/Mb across a variety of advanced solid tumors, but limited activity was observed in patients with a TMB between 10 and 16 mut/Mb.
Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer
Single-cell RNA sequencing analysis of over 200,000 gastric cancer cells forms a comprehensive molecular atlas, identifying novel cell lineages and unique interactions between tumor cells and the surrounding microenvironment.
Neuroendocrine carcinomas (NEC) of the gastrointestinal system show similar histopathologic features and share some genomic features, but considerable differences exist between pancreatic NECs and nonpancreatic NECs.
DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Targeted degradation of EP300 with a novel PROTAC agent in neuroblastoma cells was found to cause widespread loss of gene expression and cell death in vitro and in vivo.
PTP1B functions as an intracellular checkpoint that limits the cytotoxic activity of tumor-infiltrating T cells, and its deletion or inhibition can enhance the antitumor immunity of T cells and CAR T cells and the response to anti–PD-1 therapy.
Depletion of mitochondrial iron with the drug ironomycin induced a dramatic loss in mitochondrial respiration and noncanonical BAX/BAK-dependent cell death that synergized with venetoclax in mouse and patient-derived models of leukemia.
KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma
Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms
Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
News in Brief
News in Depth