Issues

The Hallmarks of Cancer provides a set of underlying principles to explain the mechanisms of malignant tumor formation and cancer progression. Originally including six hallmarks, the framework was later expanded to encompass four new features. Now, a decade later, new insights stemming from a deeper understanding of cancer and its diversity necessitate the prospective addition of several new hallmarks. These include “unlocking phenotypic plasticity,” “nonmutational epigenetic reprogramming,” “polymorphic microbiomes,” and “senescent cells.” To read more, see the review “Hallmarks of Cancer: New Additions” by Hanahan on page 31.