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1 February 2021
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The risk of skin cancers such as basal cell carcinoma and squamous cell carcinoma varies greatly across the body, and it is known that healthy aged skin cells often harbor cancer driver mutations, but whether these observations are connected has not been determined. Fowler and colleagues discovered that the mutation density in healthy human skin differed from location to location across the body. Common sites for skin cancer, such as the forearm, bore more mutations than uncommon sites, and the mutation profile suggested UV radiation as a cause. Interestingly, not only was there selection for cancer-associated mutations in healthy skin, but the DNA repair mechanisms used varied based on site. For more information, see the article by Fowler and colleagues on page 340. - PDF Icon PDF LinkTable of Contents
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ISSN 2159-8274
EISSN 2159-8290
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Science in Society
Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited
Antoni Ribas; Rajarshi Sengupta; Trevan Locke; Sayyed Kaleem Zaidi; Katie M. Campbell; John M. Carethers; Elizabeth M. Jaffee; E. John Wherry; Jean-Charles Soria; Gypsyamber D'Souza; for the AACR COVID-19 and Cancer Task Force
In Focus
A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer
Portia L. Thomas; Chioma J. Madubata; Melinda C. Aldrich; Montessa M. Lee; Taofeek K. Owonikoko; John D. Minna; Charles M. Rudin; Julien Sage; Christine M. Lovly
Reviews
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Author Choice
Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response
Meagan Montesion; Karthikeyan Murugesan; Dexter X. Jin; Radwa Sharaf; Nora Sanchez; Ameet Guria; Max Minker; Gerald Li; Virginia Fisher; Ethan S. Sokol; Dean C. Pavlick; Jay A. Moore; Alan Braly; Gaurav Singal; David Fabrizio; Leah A. Comment; Naiyer A. Rizvi; Brian M. Alexander; Garrett M. Frampton; Priti S. Hegde; Lee A. Albacker
Author Choice
Lower Airway Dysbiosis Affects Lung Cancer Progression
Jun-Chieh J. Tsay; Benjamin G. Wu; Imran Sulaiman; Katherine Gershner; Rosemary Schluger; Yonghua Li; Ting-An Yie; Peter Meyn; Evan Olsen; Luisannay Perez; Brendan Franca; Joseph Carpenito; Tadasu Iizumi; Mariam El-Ashmawy; Michelle Badri; James T. Morton; Nan Shen; Linchen He; Gaetane Michaud; Samaan Rafeq; Jamie L. Bessich; Robert L. Smith; Harald Sauthoff; Kevin Felner; Ray Pillai; Anastasia-Maria Zavitsanou; Sergei B. Koralov; Valeria Mezzano; Cynthia A. Loomis; Andre L. Moreira; William Moore; Aristotelis Tsirigos; Adriana Heguy; William N. Rom; Daniel H. Sterman; Harvey I. Pass; Jose C. Clemente; Huilin Li; Richard Bonneau; Kwok-Kin Wong; Thales Papagiannakopoulos; Leopoldo N. Segal
Research Articles
Author Choice
Personalized Antibodies for Gastroesophageal Adenocarcinoma (PANGEA): A Phase II Study Evaluating an Individualized Treatment Strategy for Metastatic Disease
Daniel V.T. Catenacci; Stephanie Moya; Samantha Lomnicki; Leah M. Chase; Bryan F. Peterson; Natalie Reizine; Lindsay Alpert; Namrata Setia; Shu-Yuan Xiao; John Hart; Uzma D. Siddiqui; D. Kyle Hogarth; Oliver S. Eng; Kiran Turaga; Kevin Roggin; Mitchell C. Posner; Paul Chang; Sunil Narula; Murtuza Rampurwala; Yuan Ji; Theodore Karrison; Chih-Yi Liao; Blase N. Polite; Hedy L. Kindler
Author Choice
Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib
Ian M. Silverman; Antoine Hollebecque; Luc Friboulet; Sherry Owens; Robert C. Newton; Huiling Zhen; Luis Féliz; Camilla Zecchetto; Davide Melisi; Timothy C. Burn
Author Choice
Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
Joanna C. Fowler; Charlotte King; Christopher Bryant; Michael W.J. Hall; Roshan Sood; Swee Hoe Ong; Eleanor Earp; David Fernandez-Antoran; Jonas Koeppel; Stefan C. Dentro; David Shorthouse; Amer Durrani; Kate Fife; Edward Rytina; Doreen Milne; Amit Roshan; Krishnaa Mahububani; Kourosh Saeb-Parsy; Benjamin A. Hall; Moritz Gerstung; Philip H. Jones
Author Choice
Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer
Shuang Zhang; Sonia Iyer; Hao Ran; Igor Dolgalev; Shengqing Gu; Wei Wei; Connor J.R. Foster; Cynthia A. Loomis; Narciso Olvera; Fanny Dao; Douglas A. Levine; Robert A. Weinberg; Benjamin G. Neel
Author Choice
Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy
Sonia Iyer; Shuang Zhang; Simge Yucel; Heiko Horn; Sean G. Smith; Ferenc Reinhardt; Esmee Hoefsmit; Bimarzhan Assatova; Julia Casado; Marie-Charlotte Meinsohn; M. Inmaculada Barrasa; George W. Bell; Fernando Pérez-Villatoro; Kaisa Huhtinen; Johanna Hynninen; Jaana Oikkonen; Pamoda M. Galhenage; Shailja Pathania; Paula T. Hammond; Benjamin G. Neel; Anniina Farkkila; David Pépin; Robert A. Weinberg
A TLR3 Ligand Reestablishes Chemotherapeutic Responses in the Context of FPR1 Deficiency
Julie Le Naour; Peng Liu; Liwei Zhao; Sandy Adjemian; Zsofia Sztupinszki; Julien Taieb; Claire Mulot; Aymeric Silvin; Charles-Antoine Dutertre; Florent Ginhoux; Allan Sauvat; Giulia Cerrato; Francesca Castoldi; Isabelle Martins; Gautier Stoll; Juliette Paillet; Khady Mangane; Cornelia Richter; Oliver Kepp; Maria Chiara Maiuri; Federico Pietrocola; Peter Vandenabeele; Fabrice André; Suzette Delaloge; Zoltan Szallasi; Pierre Laurent-Puig; Jessica Zucman-Rossi; Laurence Zitvogel; Jonathan G. Pol; Erika Vacchelli; Guido Kroemer
Timed Ang2-Targeted Therapy Identifies the Angiopoietin–Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis
Nicolas Gengenbacher; Mahak Singhal; Carolin Mogler; Ling Hai; Laura Milde; Ashik Ahmed Abdul Pari; Eva Besemfelder; Claudine Fricke; Daniel Baumann; Stephanie Gehrs; Jochen Utikal; Moritz Felcht; Junhao Hu; Matthias Schlesner; Rienk Offringa; Sudhakar R. Chintharlapalli; Hellmut G. Augustin
Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression
Ralph Francescone; Débora Barbosa Vendramini-Costa; Janusz Franco-Barraza; Jessica Wagner; Alexander Muir; Allison N. Lau; Linara Gabitova; Tatiana Pazina; Sapna Gupta; Tiffany Luong; Dustin Rollins; Ruchi Malik; Roshan J. Thapa; Diana Restifo; Yan Zhou; Kathy Q. Cai; Harvey H. Hensley; Yinfei Tan; Warren D. Kruger; Karthik Devarajan; Siddharth Balachandran; Andres J. Klein-Szanto; Huamin Wang; Wafik S. El-Deiry; Matthew G. Vander Heiden; Suraj Peri; Kerry S. Campbell; Igor Astsaturov; Edna Cukierman
The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells
Deobrat Dixit; Briana C. Prager; Ryan C. Gimple; Hui Xian Poh; Yang Wang; Qiulian Wu; Zhixin Qiu; Reilly L. Kidwell; Leo J.Y. Kim; Qi Xie; Kristoffer Vitting-Seerup; Shruti Bhargava; Zhen Dong; Li Jiang; Zhe Zhu; Petra Hamerlik; Samie R. Jaffrey; Jing Crystal Zhao; Xiuxing Wang; Jeremy N. Rich
Author Choice
The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG
Haobin Ye; Mohammad Minhajuddin; Anna Krug; Shanshan Pei; Chih-Hsing Chou; Rachel Culp-Hill; Jessica Ponder; Erik De Bloois; Björn Schniedewind; Maria L. Amaya; Anagha Inguva; Brett M. Stevens; Daniel A. Pollyea; Uwe Christians; H. Leighton Grimes; Angelo D'Alessandro; Craig T. Jordan
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