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1 June 2020
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The COVID-19 pandemic has raised questions about the impact of the disease on patients with cancer, who are generally more susceptible to infections. Dai and colleagues report the results of a multicenter study in Wuhan, China, comparing patients with cancer to age-matched controls, all diagnosed with COIVD-19. Substantial differences in prognosis based on cancer stage and type emerged: Stage IV cancer conferred a much worse prognosis than non-metastatic cancer, and patients with hematologic or lung malignancies were most at risk for severe complications of COVID-19. For details, please see the article by Dai and colleagues on page 783. Additional coverage of the relationship between COVID-19 and cancer can be found in the News and In Focus sections of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 2159-8274
EISSN 2159-8290
In This Issue
In the Spotlight
Science in Society
In Focus
Research Brief
Author Choice
Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
Mengyuan Dai; Dianbo Liu; Miao Liu; Fuxiang Zhou; Guiling Li; Zhen Chen; Zhian Zhang; Hua You; Meng Wu; Qichao Zheng; Yong Xiong; Huihua Xiong; Chun Wang; Changchun Chen; Fei Xiong; Yan Zhang; Yaqin Peng; Siping Ge; Bo Zhen; Tingting Yu; Ling Wang; Hua Wang; Yu Liu; Yeshan Chen; Junhua Mei; Xiaojia Gao; Zhuyan Li; Lijuan Gan; Can He; Zhen Li; Yuying Shi; Yuwen Qi; Jing Yang; Daniel G. Tenen; Li Chai; Lorelei A. Mucci; Mauricio Santillana; Hongbing Cai
Research Articles
Author Choice
The Evolutionary Origins of Recurrent Pancreatic Cancer
Hitomi Sakamoto; Marc A. Attiyeh; Jeffrey M. Gerold; Alvin P. Makohon-Moore; Akimasa Hayashi; Jungeui Hong; Rajya Kappagantula; Lance Zhang; Jerry P. Melchor; Johannes G. Reiter; Alexander Heyde; Craig M. Bielski; Alexander V. Penson; Mithat Gönen; Debyani Chakravarty; Eileen M. O'Reilly; Laura D. Wood; Ralph H. Hruban; Martin A. Nowak; Nicholas D. Socci; Barry S. Taylor; Christine A. Iacobuzio-Donahue
Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
Zhaoqi Liu; Akihide Yoshimi; Jiguang Wang; Hana Cho; Stanley Chun-Wei Lee; Michelle Ki; Lillian Bitner; Timothy Chu; Harshal Shah; Bo Liu; Anthony R. Mato; Peter Ruvolo; Giulia Fabbri; Laura Pasqualucci; Omar Abdel-Wahab; Raul Rabadan
Combined Cohesin–RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes
Yotaro Ochi; Ayana Kon; Toyonori Sakata; Masahiro M Nakagawa; Naotaka Nakazawa; Masanori Kakuta; Keisuke Kataoka; Haruhiko Koseki; Manabu Nakayama; Daisuke Morishita; Tatsuaki Tsuruyama; Ryunosuke Saiki; Akinori Yoda; Rurika Okuda; Tetsuichi Yoshizato; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Shinichi Kotani; Yasunori Kogure; Nobuyuki Kakiuchi; Tomomi Nishimura; Hideki Makishima; Luca Malcovati; Akihiko Yokoyama; Kengo Takeuchi; Eiji Sugihara; Taka-Aki Sato; Masashi Sanada; Akifumi Takaori-Kondo; Mario Cazzola; Mineko Kengaku; Satoru Miyano; Katsuhiko Shirahige; Hiroshi I. Suzuki; Seishi Ogawa
Author Choice
Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression
Salina Yuan; Ramakrishnan Natesan; Francisco J. Sanchez-Rivera; Jinyang Li; Natarajan V. Bhanu; Taiji Yamazoe; Jeffrey H. Lin; Allyson J. Merrell; Yogev Sela; Stacy K. Thomas; Yanqing Jiang; Jacqueline B. Plesset; Emma M. Miller; Junwei Shi; Benjamin A. Garcia; Scott W. Lowe; Irfan A. Asangani; Ben Z. Stanger
Author Choice
Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Nathiya Muthalagu; Tiziana Monteverde; Ximena Raffo-Iraolagoitia; Robert Wiesheu; Declan Whyte; Ann Hedley; Sarah Laing; Björn Kruspig; Rosanna Upstill-Goddard; Robin Shaw; Sarah Neidler; Curtis Rink; Saadia A. Karim; Katarina Gyuraszova; Colin Nixon; William Clark; Andrew V. Biankin; Leo M. Carlin; Seth B. Coffelt; Owen J. Sansom; Jennifer P. Morton; Daniel J. Murphy
News in Brief
News in Depth
Research Watch
Autophagy
Clinical Trials
Drug Development
Immunology
Lymphoma
Medulloblastoma
Mutations
Pancreatic Cancer
Senescence
Techniques
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