Skip Nav Destination
Issues
1 April 2020
-
Cover Image
Cover Image
Not all patients respond to CAR T-cell therapies, and the mechanisms behind this primary resistance are poorly understood. Singh, Lee, and colleagues found that deficits in death receptor signaling in acute lymphoblastic leukemia (ALL) cells can cause resistance to CD19-directed CAR T-cell therapy. Exposure to ALL cells in which death-receptor signaling was impaired caused CAR T-cell dysfunction that worsened with increasing exposure times. These dysfunctional CAR T cells exhibited a phenotype similar to that of exhausted T cells. Additionally, analysis of samples from clinical trials of CD19-directed CAR T cells showed that low expression of death receptor genes was associated with poorer response, demonstrating the clinical relevance of these findings. For details, please see the article by Singh, Lee, and colleagues on page 552.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 2159-8274
EISSN 2159-8290
In This Issue
In the Spotlight
Mini Review
Review
Research Articles
Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry
Lillian M. Smyth; Qin Zhou; Bastien Nguyen; Celeste Yu; Eva M. Lepisto; Monica Arnedos; Michael J. Hasset; Michele L. Lenoue-Newton; Natalie Blauvelt; Semih Dogan; Christine M. Micheel; Chetna Wathoo; Hugo Horlings; Jan Hudecek; Benjamin E. Gross; Ritika Kundra; Shawn M. Sweeney; JianJiong Gao; Nikolaus Schultz; Andrew Zarski; Stuart M. Gardos; Jocelyn Lee; Seth Sheffler-Collins; Ben H. Park; Charles L. Sawyers; Fabrice André; Mia Levy; Funda Meric-Bernstam; Philippe L. Bedard; Alexia Iasonos; Deborah Schrag; David M. Hyman; for the AACR Project GENIE Consortium
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia
Shanshan Pei; Daniel A. Pollyea; Annika Gustafson; Brett M. Stevens; Mohammad Minhajuddin; Rui Fu; Kent A. Riemondy; Austin E. Gillen; Ryan M. Sheridan; Jihye Kim; James C. Costello; Maria L. Amaya; Anagha Inguva; Amanda Winters; Haobin Ye; Anna Krug; Courtney L. Jones; Biniam Adane; Nabilah Khan; Jessica Ponder; Jeffrey Schowinsky; Diana Abbott; Andrew Hammes; Jason R. Myers; John M. Ashton; Travis Nemkov; Angelo D'Alessandro; Jonathan A. Gutman; Haley E. Ramsey; Michael R. Savona; Clayton A. Smith; Craig T. Jordan
Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Nathan Singh; Yong Gu Lee; Olga Shestova; Pranali Ravikumar; Katharina E. Hayer; Seok Jae Hong; Xueqing Maggie Lu; Raymone Pajarillo; Sangya Agarwal; Shunichiro Kuramitsu; Elena J. Orlando; Karen Thudium Mueller; Charly R. Good; Shelley L. Berger; Ophir Shalem; Matthew D. Weitzman; Noelle V. Frey; Shannon L. Maude; Stephan A. Grupp; Carl H. June; Saar Gill; Marco Ruella
Author Choice
Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs
Stephanie M. Dobson; Laura García-Prat; Robert J. Vanner; Jeffrey Wintersinger; Esmé Waanders; Zhaohui Gu; Jessica McLeod; Olga I. Gan; Ildiko Grandal; Debbie Payne-Turner; Michael N. Edmonson; Xiaotu Ma; Yiping Fan; Veronique Voisin; Michelle Chan-Seng-Yue; Stephanie Z. Xie; Mohsen Hosseini; Sagi Abelson; Pankaj Gupta; Michael Rusch; Ying Shao; Scott R. Olsen; Geoffrey Neale; Steven M. Chan; Gary Bader; John Easton; Cynthia J. Guidos; Jayne S. Danska; Jinghui Zhang; Mark D. Minden; Quaid Morris; Charles G. Mullighan; John E. Dick
Author Choice
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Nicole M. Sodir; Roderik M. Kortlever; Valentin J.A. Barthet; Tania Campos; Luca Pellegrinet; Steven Kupczak; Panayiotis Anastasiou; Lamorna Brown Swigart; Laura Soucek; Mark J. Arends; Trevor D. Littlewood; Gerard I. Evan
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment
Prasenjit Dey; Jun Li; Jianhua Zhang; Surendra Chaurasiya; Anders Strom; Huamin Wang; Wen-Ting Liao; Frederick Cavallaro; Parker Denz; Vincent Bernard; Er-Yen Yen; Giannicola Genovese; Pat Gulhati; Jielin Liu; Deepavali Chakravarti; Pingna Deng; Tingxin Zhang; Federica Carbone; Qing Chang; Haoqiang Ying; Xiaoying Shang; Denise J. Spring; Bidyut Ghosh; Nagireddy Putluri; Anirban Maitra; Y. Alan Wang; Ronald A. DePinho
News in Brief
News in Depth
Research Watch
Cell Death
Clinical Trials
Immunology
Immunotherapy
Metabolism
Metastasis
Mutations
Structural Biology
Transcription
Advertisement