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1 March 2020
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Cancer-cell stemness is associated with immunosuppression and poor prognosis in glioblastoma and many other malignancies. Chen and colleagues found that depletion of the circadian-rhythm gene CLOCK in glioma stem cells (GSC) led to reduced self-renewal capabilities and decreased markers of immunosuppressive microglia infiltration. Mechanistically, CLOCK-depleted cells had reduced levels of OLFML3, encoding a secreted protein involved in intercellular interactions. In mouse models, tumors derived from CLOCK-depleted GSCs were less aggressive than those derived from control GSCs, leading to increased survival in mice bearing CLOCK-depleted tumors, and exhibited reduced signs of stemness and microglia infiltration. Bolstering the proposed mechanism, tumors derived from OLFML3-depleted GSCs were also less aggressive than controls. For details, please see the article by Chen and colleagues on page 371.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 2159-8274
EISSN 2159-8290
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Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing
Jun-Bao Fan; Sayuri Miyauchi; Hui-Zhong Xu; Dan Liu; Leo J.Y. Kim; Christoph Burkart; Hua Cheng; Kei-ichiro Arimoto; Ming Yan; Yu Zhou; Balázs Győrffy; Klaus-Peter Knobeloch; Jeremy N. Rich; Hu Cang; Xiang-Dong Fu; Dong-Er Zhang
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Acalabrutinib plus Obinutuzumab in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia
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Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma
Tomohiro Aoki; Lauren C. Chong; Katsuyoshi Takata; Katy Milne; Monirath Hav; Anthony Colombo; Elizabeth A. Chavez; Michael Nissen; Xuehai Wang; Tomoko Miyata-Takata; Vivian Lam; Elena Viganò; Bruce W. Woolcock; Adèle Telenius; Michael Y. Li; Shannon Healy; Chanel Ghesquiere; Daniel Kos; Talia Goodyear; Johanna Veldman; Allen W. Zhang; Jubin Kim; Saeed Saberi; Jiarui Ding; Pedro Farinha; Andrew P. Weng; Kerry J. Savage; David W. Scott; Gerald Krystal; Brad H. Nelson; Anja Mottok; Akil Merchant; Sohrab P. Shah; Christian Steidl
Author Choice
Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis
Yaqing Zhang; Jenny Lazarus; Nina G. Steele; Wei Yan; Ho-Joon Lee; Zeribe C. Nwosu; Christopher J. Halbrook; Rosa E. Menjivar; Samantha B. Kemp; Veerin R. Sirihorachai; Ashley Velez-Delgado; Katelyn Donahue; Eileen S. Carpenter; Kristee L. Brown; Valerie Irizarry-Negron; Anna C. Nevison; Alekya Vinta; Michelle A. Anderson; Howard C. Crawford; Costas A. Lyssiotis; Timothy L. Frankel; Filip Bednar; Marina Pasca di Magliano
Author Choice
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma
Patrizia Mondello; Saber Tadros; Matt Teater; Lorena Fontan; Aaron Y. Chang; Neeraj Jain; Haopeng Yang; Shailbala Singh; Hsia-Yuan Ying; Chi-Shuen Chu; Man Chun John Ma; Eneda Toska; Stefan Alig; Matthew Durant; Elisa de Stanchina; Sreejoyee Ghosh; Anja Mottok; Loretta Nastoupil; Sattva S. Neelapu; Oliver Weigert; Giorgio Inghirami; José Baselga; Anas Younes; Cassian Yee; Ahmet Dogan; David A. Scheinberg; Robert G. Roeder; Ari M. Melnick; Michael R. Green
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