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1 July 2011
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Cover Image
Cover Image
Cheung and colleagues report aberrations in the PI3K pathway occur in a majority of endometrioid endometrial cancers, with coordinate mutations of multiple pathway members being more common than predicted by chance. Multiple gain-of-function PIK3R1 and PIK3R2 mutations result in the stabilization of PTEN protein with likely contribution from the ubiquitin-proteasome degradative pathway, as depicted by the cover. For details, please see the article by Cheung and colleagues on page 158. - PDF Icon PDF LinkTable of Contents
ISSN 2159-8274
EISSN 2159-8290
In This Issue
News in Brief
News in Depth
Research Watch
In the Spotlight
Prospective
Review
Research Briefs
Temporal Dissection of Tumorigenesis in Primary Cancers
Steffen Durinck; Christine Ho; Nicholas J. Wang; Wilson Liao; Lakshmi R. Jakkula; Eric A. Collisson; Jennifer Pons; Sai-Wing Chan; Ernest T. Lam; Catherine Chu; Kyunghee Park; Sung-woo Hong; Joe S. Hur; Nam Huh; Isaac M. Neuhaus; Siegrid S. Yu; Roy C. Grekin; Theodora M. Mauro; James E. Cleaver; Pui-Yan Kwok; Philip E. LeBoit; Gad Getz; Kristian Cibulskis; Jon C. Aster; Haiyan Huang; Elizabeth Purdom; Jian Li; Lars Bolund; Sarah T. Arron; Joe W. Gray; Paul T. Spellman; Raymond J. Cho
Research Articles
PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network
Haoqiang Ying; Kutlu G. Elpek; Anant Vinjamoori; Stephanie M. Zimmerman; Gerald C. Chu; Haiyan Yan; Eliot Fletcher-Sananikone; Hailei Zhang; Yingchun Liu; Wei Wang; Xiaojia Ren; Hongwu Zheng; Alec C. Kimmelman; Ji-hye Paik; Carol Lim; Samuel R. Perry; Shan Jiang; Brian Malinn; Alexei Protopopov; Simona Colla; Yonghong Xiao; Aram F. Hezel; Nabeel Bardeesy; Shannon J. Turley; Y. Alan Wang; Lynda Chin; Sarah P. Thayer; Ronald A. DePinho
High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
Lydia W.T. Cheung; Bryan T. Hennessy; Jie Li; Shuangxing Yu; Andrea P. Myers; Bojana Djordjevic; Yiling Lu; Katherine Stemke-Hale; Mary D. Dyer; Fan Zhang; Zhenlin Ju; Lewis C. Cantley; Steven E. Scherer; Han Liang; Karen H. Lu; Russell R. Broaddus; Gordon B. Mills
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